Virtual LASO-3 diet program to ease chemotherapy-related numbness and tingling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study delivers the LASO-3 diet program virtually through nutrition education sessions led by a Registered Dietitian, with goals of lower added sugar, higher fiber, and increased omega-3 intake based on U.S. Dietary Guidelines. Participants are cancer survivors at least three months after their last neurotoxic chemotherapy who report at least moderate numbness and tingling and can participate in English-language online sessions. The study collects surveys, interviews, biospecimens, and electronic health record data to measure changes in chemotherapy-induced peripheral neuropathy symptoms and related biomarkers. Individuals with pre-existing neuropathy, routine anti-inflammatory drug or steroid use, or high baseline fish/omega-3 intake are excluded to isolate the diet effect.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older
* At least three months since last receiving neurotoxic chemotherapy
* Self-report moderate (≥ 2/4) numbness and tingling on the Patient Reported Outcomes-Common Terminology Criteria for Adverse Events (PRO-CTCAE™) Numbness and Tingling Severity Item in the last week
* Speak/read English
* Have access to the internet

Exclusion Criteria:

* Pre-existing peripheral neuropathy from any cause
* Plan to begin a new prescription of duloxetine (i.e., first-line treatment for CIPN pain) during the study period
* Are enrolled in symptom management trials that may alter CIPN severity
* High grade inflammatory disease such as lupus, Crohn's disease, or rheumatoid arthritis
* Routine nonsteroidal anti-inflammatory drug (NSAID) or steroid supplementation
* Consuming an average three or more servings of fish per week and/or consuming fish oil capsules containing eicosapentaenoic acid (EPA)+ docosahexaenoic acid (DHA) daily or consuming flax oil capsules daily
* Consuming an average of less than 5 servings of sweets, candy bars, chocolate, doughnuts, cookies, cakes, pie, brownies, ice cream, pastries, or sugar sweetened beverages (e.g., soda or coffee/tea) per week

Where it's running

• University of Michigan Rogel Cancer Center
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Robert Knoerl — University of Michigan Rogel Cancer Center

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.