Modeling cancer treatment side effects using patient blood samples

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to generate induced pluripotent stem cells (iPSCs) from patients undergoing cancer treatment to model and understand the adverse effects associated with cancer therapies. By differentiating these iPSCs into relevant cell types such as cardiomyocytes and neurons, researchers will investigate the mechanisms behind toxicities like cardiotoxicity and neurotoxicity. The study will also explore whether specific genetic variants in patients contribute to these toxicities and screen for potential protective therapies. Blood samples will be collected, and medical records will be reviewed to support these objectives.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any patient \>= 18 years of age
* Previously treated, planned or currently receiving any potentially toxic cancer therapy including but not limited to chemotherapy, targeted and immunotherapies

Exclusion Criteria:

* Inability on the part of the patient to understand the informed consent or be compliant with the protocol

Where it's running

• Mayo Clinic in Florida
  Jacksonville, Florida, United States Recruiting

Study contacts

• Principal investigator: Nadine Norton, PhD — Mayo Clinic
• Study coordinator: Clinical Trials Referral Office
• Email: mayocliniccancerstudies@mayo.edu
• Phone: 855-776-0015

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.