Understanding how gut bacteria influence cancer treatment
Official title: Role of Gut Microbiome in Cancer Therapy
Run by Mayo Clinic · NCT05112614 · Data updated 2026-11-12
This study looks at how the bacteria in your gut might affect how well cancer treatments work for people with certain types of cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 3 sites (Scottsdale, Arizona and 2 other locations) |
| Status | Recruiting |
| Started | September 11, 2019 |
| Main results expected | October 1, 2030 |
| Study ends | October 1, 2030 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT05112614 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18-99 who have been diagnosed with cancer and are undergoing or scheduled to start cancer therapy or a stem cell transplant.
✕Probably not a fit
Patients who are unable to provide informed consent or are considered vulnerable adults may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationship between the gut microbiome and the effectiveness of cancer therapies in patients with hematopoietic and lymphoid cell neoplasms or malignant solid neoplasms. By collecting blood and stool samples and reviewing medical records, researchers aim to correlate specific gut microbiome profiles with clinical responses and side effects of cancer treatments and stem cell transplants. The findings may lead to improved cancer treatment strategies tailored to individual microbiome compositions.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of cancer therapies by personalizing treatment based on gut microbiome profiles.
How similar studies have gone: Other studies have shown promising results in understanding the role of the microbiome in cancer treatment, suggesting that this approach is both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-99 * Diagnosis of cancer and undergoing cancer therapy or scheduled to start cancer therapy or undergoing stem cell transplant for any hematological condition Exclusion Criteria: * Unable to provide informed consent * Vulnerable adults
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting -
Mayo Clinic in Arizona
Scottsdale, Arizona, United States Active not recruiting -
Mayo Clinic in Florida
Jacksonville, Florida, United States Active not recruiting
Study contacts
- Principal investigator: Purna C. Kashyap, MBBS — Mayo Clinic in Rochester
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.