Understanding how gut bacteria influence cancer treatment
Role of Gut Microbiome in Cancer Therapy
This study looks at how the bacteria in your gut might affect how well cancer treatments work for people with certain types of cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 3 sites (Scottsdale, Arizona and 2 other locations) |
| Trial ID | NCT05112614 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between the gut microbiome and the effectiveness of cancer therapies in patients with hematopoietic and lymphoid cell neoplasms or malignant solid neoplasms. By collecting blood and stool samples and reviewing medical records, researchers aim to correlate specific gut microbiome profiles with clinical responses and side effects of cancer treatments and stem cell transplants. The findings may lead to improved cancer treatment strategies tailored to individual microbiome compositions.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-99 who have been diagnosed with cancer and are undergoing or scheduled to start cancer therapy or a stem cell transplant.
Not a fit: Patients who are unable to provide informed consent or are considered vulnerable adults may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of cancer therapies by personalizing treatment based on gut microbiome profiles.
How similar studies have performed: Other studies have shown promising results in understanding the role of the microbiome in cancer treatment, suggesting that this approach is both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-99 * Diagnosis of cancer and undergoing cancer therapy or scheduled to start cancer therapy or undergoing stem cell transplant for any hematological condition Exclusion Criteria: * Unable to provide informed consent * Vulnerable adults
Where this trial is running
Scottsdale, Arizona and 2 other locations
- Mayo Clinic in Arizona — Scottsdale, Arizona, United States (Active_not_recruiting)
- Mayo Clinic in Florida — Jacksonville, Florida, United States (Active_not_recruiting)
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Purna C. Kashyap, MBBS — Mayo Clinic in Rochester
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.