Vanguard: a new blood test approach to screen for multiple cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized feasibility study will enroll adults aged 45–75 without a recent cancer diagnosis and assign them to one of two multi-cancer detection (MCD) blood-test groups or a control group receiving usual care. Participants will provide blood at enrollment and again at one year, and researchers will collect medical record data to track results, follow-up diagnostics, and standard screening behaviors. The trial focuses on feasibility outcomes—recruitment, adherence, representativeness across sites, timeliness of result return, and diagnostic resolution of abnormal tests—rather than definitive effectiveness. Results will guide design and procedures for a larger randomized trial of MCD screening.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 45-75 years old
* Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment
* Agree to allow collection of information from their medical records for study-related purposes
* Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic

  * Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion

Exclusion Criteria:

* Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years

  * Note: Persons with a history of in situ cancers (e.g., ductal carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ) or nonmelanoma skin cancer are eligible. Persons with a history of prostate cancer that has not been treated are not eligible, regardless of when the diagnosis occurred
* Ongoing cancer diagnostic work-up
* Ongoing participation in another study of an investigational cancer screening test or technology not currently utilized in routine clinical practice
* Currently breastfeeding or pregnant, or planning to become pregnant in the next year
* History of solid organ or hematopoietic transplantation at any time, or blood transfusion within the last 30 days

Where it's running

• Kaiser Permanente-Division of Research
  Pleasanton, California, United States Recruiting
• Naval Medical Center -San Diego
  San Diego, California, United States Recruiting
• Keefe Memorial Hospital
  Cheyenne Wells, Colorado, United States Recruiting
• Kaiser Permanente-Franklin
  Denver, Colorado, United States Recruiting
• Poudre Valley Hospital
  Fort Collins, Colorado, United States Recruiting
• Cancer Care and Hematology-Fort Collins
  Fort Collins, Colorado, United States Recruiting

Study contacts

• Principal investigator: Scott D Ramsey — Fred Hutchinson Cancer Center

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Imaging study using two antibody fragments in patients with solid tumors

  This study is testing two special antibody fragments in people with solid tumors to see how well they target cancer cells and how they move through the body.

  Recruiting Early Phase 1 Var2 Pharmaceuticals · Groningen, Provincie Groningen · NCT06645808

• Collecting data on side effects of proton therapy for cancer treatment

  This study is trying to learn about the side effects that cancer patients experience after receiving proton therapy to help improve future treatments.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT00991094

• Using fucoidan to prevent fatigue in cancer patients undergoing chemotherapy

  This study tests if a seaweed supplement called fucoidan can help cancer patients undergoing chemotherapy feel less tired.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06855524

• Improving access to genetic testing for underserved cancer patients

  This study is testing whether a computer character can give better information about genetic testing to underserved cancer patients compared to regular human healthcare providers.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06422455

• Using patient-derived cancer models to address health disparities in cancer treatment

  This study is trying to create and test cancer models from patients, especially those from minority backgrounds, to see how we can improve cancer treatments for bladder, gastric, liver, and lung cancers.

  Recruiting at 2 sites University of California, Davis · Orange, California and 1 other locations · NCT04410302

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.