Analyzing cancer genetics for better prevention and treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify genetic markers and causes of cancer by analyzing patients' DNA, RNA, plasma, tissues, and other samples. It focuses on cancer genetic testing to find specific changes in cancer and normal cells, which may lead to improved prevention, screening, and treatment strategies. Additionally, the study will create a biobank of samples and information to further research in cancer treatment. Participants will undergo pan-genomic testing to discover genetic variants that could enhance cancer management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

GROUP A: Germline and Somatic Testing

* Has Mayo Clinic medical record number
* Confirmed cancer diagnosis
* Germline and/or somatic tumor/blood testing has been ordered by the clinical provider (or clinical delegate)
* Participant aware of cancer diagnosis
* Able to provide informed consent
* ≥ 18 years old
* Ability to provide blood, saliva, bone marrow aspirate or hair follicle sample
* Ability to provide archived tissue, if somatic testing has not already been completed

  * Note: if tissue unavailable participant may still enroll onto the study for the germline collection, or vice versa, if germline has already been completed may still enroll for somatic tissue/blood testing.

GROUP B: Germline testing only:

* Has Mayo Clinic medical record number
* Confirmed cancer diagnosis
* Germline testing has been ordered by the clinical provider (or clinical delegate)
* Participant aware of cancer diagnosis
* Able to provide informed consent
* ≥ 18 years old
* Ability to provide blood, saliva, or hair follicle sample

GROUP C: Somatic tumor testing only:

* Has Mayo Clinic medical record number,
* Confirmed cancer diagnosis,
* Somatic tumor/blood testing has been ordered by the clinical provider (or clinical delegate)
* Participant aware of cancer diagnosis,
* Able to provide informed consent,
* ≥ 18 years old
* Ability to provide archived tissue or blood for somatic tumor genomic profiling, if not already completed.

Group D: Clinical standard of care germline testing via genetic counselor:

* Has Mayo Clinic medical record number,
* Standard of care clinical visit with genetic counselor
* Confirmed cancer diagnosis,
* Germline testing has been ordered by the clinical provider (or clinical delegate)
* Participant aware of cancer diagnosis,
* Able to provide informed consent,
* ≥ 18 years old
* Ability to provide blood, saliva, or hair follicle sample

Group E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810:

* Enrolled in any of the following studies: IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810
* Completed Riskguard, OncoExtra, Caris Assure, or Caris MI Profile or any combination of these tests.
* Has Mayo Clinic medical record number,
* Confirmed cancer diagnosis,
* Participant aware of cancer diagnosis
* Able to provide informed consent,
* ≥ 18 years old

Exclusion Criteria:

Note: Women who are pregnant or planning to become pregnant can take part in this study.

GROUP A: Germline and Somatic testing

* Individuals who have situations that would limit compliance with the study requirements
* Institutionalized (i.e. Federal Medical Prison)

GROUP B: Germline testing only

* Individuals who have situations that would limit compliance with the study requirements
* Institutionalized (i.e. Federal Medical Prison)
* Prior germline genetic testing with a 100+ multi-gene panel within the last 1 year of enrollment

Group C: Somatic tumor testing only:

* Individuals who have situations that would limit compliance with the study requirements,
* Institutionalized (i.e. Federal Medical Prison),

Group D: Clinical standard of care germline testing via genetic counselor:

* Individuals who have situations that would limit compliance with the study requirements,
* Institutionalized (i.e. Federal Medical Prison)

Group E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810:

* Individuals who have situations that would limit compliance with the study requirements,
* Institutionalized (i.e. Federal Medical Prison)

Where it's running

• Mayo Clinic in Arizona
  Scottsdale, Arizona, United States Recruiting
• Mayo Clinic in Florida
  Jacksonville, Florida, United States Recruiting
• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting
• Mayo Clinic Health System-Eau Claire Clinic
  Eau Claire, Wisconsin, United States Recruiting
• Mayo Clinic Health System-Franciscan Healthcare
  La Crosse, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Jewel J. Samadder, MD — Mayo Clinic
• Study coordinator: Cancer Center CRC Team
• Email: Interception@mayo.edu
• Phone: 507-266-7492

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.