Condition
Chemotherapy-induced Peripheral Neuropathy clinical trials and research
As of November 12, 2026, Find a Trial lists 36 Chemotherapy-induced Peripheral Neuropathy clinical trials that are recruiting, at sites in 25 countries (most in United States (17), Spain (3), Italy (3)). By phase: Phase 2 (4), Phase 2/3 (2), Phase 1 (1), Phase 3 (1). The most active sponsors are University of Michigan Rogel Cancer Center (2), Hospital Universitario de Gran Canaria Doctor Negrín (2), M.D. Anderson Cancer Center (2). There are also 41 NIH-funded research projects on Chemotherapy-induced Peripheral Neuropathy, with $19.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 36Clinical trials
- 41NIH research projects
- 25Countries
Newest Chemotherapy-induced Peripheral Neuropathy clinical trials
All recruiting trials (36)
-
Cryotherapy during weekly paclitaxel to reduce chemotherapy-induced numbness and tingling
This study tests whether applying cryotherapy to hands and feet during weekly paclitaxel helps prevent CIPN in women with breast cancer.
-
SIR2501 plus Paclitaxel for solid tumors
This Phase 2 study tests SIR2501 in adults with solid tumors who are starting paclitaxel chemotherapy to see if it is safe and tolerable and to explore its effect on chemotherapy-induced neuropathy.
-
Non-invasive brain stimulation to help chemotherapy-induced nerve problems in cancer survivors
This trial tests whether a gentle brain stimulation method (tDCS) can help reduce numbness, tingling, and pain from CIPN in cancer survivors who are not currently in treatment.
-
Self-applied ear vagus nerve stimulation for chemotherapy-induced neuropathy
Researchers are testing a small, at-home device that you wear on the ear to see if it eases nerve pain from chemotherapy.
-
Blood extracellular vesicles to detect chemotherapy-related nerve damage.
We will test whether tiny blood particles called extracellular vesicles can predict who will develop chemotherapy-induced peripheral neuropathy in adults receiving taxane, platinum, or antimitotic chemotherapy.
-
Virtual LASO-3 diet program to ease chemotherapy-related numbness and tingling
This trial tests whether a virtual diet program that lowers added sugar and increases fiber and omega-3s can help cancer survivors who have numbness, tingling, or pain after neurotoxic chemotherapy.
-
Ozone therapy for refractory pain and quality of life in cancer patients
This study looks at whether adjuvant ozone therapy can improve quality of life for adults with difficult-to-treat cancer-related symptoms referred to a palliative pain unit.
-
Scrambler Therapy for chemotherapy-related nerve pain (CIPN).
Researchers will try Scrambler Therapy, a non-drug electrical treatment, to reduce pain and numbness in people with long-lasting chemotherapy-induced peripheral neuropathy.
-
Video-guided imagined acupuncture for chemotherapy-related nerve pain
This program will try a video-guided imagined acupuncture (VGAIT) approach to help people with ongoing nerve pain after taxane chemotherapy for early-stage breast cancer.
-
Compression stockings to prevent peripheral neuropathy in patients receiving MMAE-containing ADCs for urothelial cancer
This study will test whether wearing a medical compression stocking on one foot during antibody–drug conjugate (MMAE-containing) infusions can prevent peripheral neuropathy in adults with advanced urothelial carcinoma or other cancers.
-
VMD-3866 topical gel for chemotherapy-induced nerve pain
This trial will test whether a non-opioid topical gel called VMD-3866 can reduce pain in adults with chemotherapy-induced peripheral neuropathy.
-
Cryocompression to prevent taxane-induced nerve damage in the arms and legs.
This study tests whether cooling and pressure applied to the arms and legs during taxane chemotherapy can prevent or reduce numbness, pain, or weakness from peripheral neuropathy in adults with breast or gynecologic cancer.
-
At-home light therapy for chemo-related nerve pain in childhood cancer survivors
This study tests whether a six-week at-home light therapy program can help childhood cancer survivors who have chemotherapy-induced peripheral neuropathy.
-
CBG/CBD oil for chemotherapy-induced peripheral neuropathy
This will try a CBG/CBD oil to see if it safely reduces pain, numbness, or other nerve symptoms in adults who developed peripheral neuropathy after platinum-based chemotherapy for gastrointestinal cancers.
-
Acupuncture to reduce chemotherapy-related nerve pain after gynecologic cancer
This pilot will try acupuncture to see if it reduces chemotherapy-caused nerve pain (peripheral neuropathy) in people treated for gynecological cancers with carboplatin and paclitaxel.
-
Sensorimotor training for breast cancer patients with chemotherapy-induced peripheral neuropathy
This study tests if sensorimotor training can help breast cancer patients with nerve pain from chemotherapy feel better and improve their balance and exercise ability.
-
Phytocannabinoids to reduce chronic chemotherapy-related nerve pain in breast and colon cancer survivors
This will test whether daily CBD or a combined THC:CBD treatment can reduce long-term nerve pain, tingling, and numbness in people who survived breast or colon cancer.
-
Explicit Sensory Retraining for Chemo-Induced Peripheral Neuropathy
This study tests whether three sessions of explicit sensory retraining for the legs, compared with usual care, can help reduce symptoms and improve function in adults with CIPN after chemotherapy.
-
Predicting nerve damage from chemotherapy in gastric cancer patients
This study is testing a new blood test to see if it can help predict which gastric cancer patients are at risk of nerve damage from chemotherapy, so doctors can tailor their treatment accordingly.
-
Identifying patients at risk for nerve damage from paclitaxel
This study is trying to see if measuring a specific protein in the blood can help predict which breast cancer patients might experience nerve damage from the chemotherapy drug paclitaxel.
-
Tracking and preventing nerve pain from chemotherapy
This study is testing how to track and prevent nerve pain caused by chemotherapy in breast cancer patients by monitoring their brain activity and trying a new brain-computer interface to help reduce the pain.
-
Using peripheral nerve stimulation to treat pain from chemotherapy-induced nerve damage
This study is testing if a treatment called peripheral nerve stimulation can help reduce pain for people suffering from nerve damage caused by chemotherapy.
-
Using cryocompression to reduce nerve pain from chemotherapy in gynecologic cancer patients
This study is testing if using cold therapy with compression can help reduce nerve pain from chemotherapy in women with gynecologic cancer better than just cold therapy alone.
-
Electrical stimulation to relieve chemotherapy-related nerve pain in breast cancer patients
This study is testing whether a special electrical treatment can help breast cancer patients who have nerve pain from chemotherapy feel better.
-
Capsaicin patch compared to oral duloxetine for chemotherapy-induced nerve pain
This study is testing whether a capsaicin patch or an oral medication called duloxetine works better to relieve nerve pain in cancer patients who have had chemotherapy.
-
Using methadone to relieve painful nerve damage from chemotherapy
This study is testing whether methadone can help cancer patients with painful nerve damage from chemotherapy feel better compared to a common medication called duloxetine.
-
Using light therapy to manage nerve pain from chemotherapy
This study is testing if light therapy can help cancer patients feel less nerve pain caused by chemotherapy.
-
Investigating dizziness and muscle weakness in older colorectal cancer patients during chemotherapy
This study is testing whether a special exercise program and health check-ups can help older colorectal cancer patients feel less dizzy and improve their balance during chemotherapy.
-
Limb cryocompression to prevent chemotherapy-related nerve damage
We will test whether cooling your arms and legs with the Paxman Limb Cryocompression System can prevent nerve damage in people with cancer receiving weekly paclitaxel chemotherapy.
-
Effect of spinal cord stimulation on pain and quality of life in chemotherapy-induced peripheral neuropathy
This study is testing if spinal cord stimulation can help reduce pain and improve quality of life for people dealing with nerve pain from chemotherapy.
-
Duloxetine for treating painful nerve damage in cancer patients after taxane chemotherapy
This study is testing if duloxetine can help Chinese cancer patients with painful nerve damage caused by chemotherapy feel better and improve their quality of life.
-
Measuring nerve damage in children receiving chemotherapy
This study is testing a new way to measure nerve damage in children and teens with leukemia who are getting a chemotherapy drug called vincristine, to see if it helps catch problems earlier.
-
Remote monitoring and management of nerve damage from chemotherapy
This study tests a new way to help people with nerve damage from chemotherapy by having them report their symptoms online and comparing regular care to extra support from a nurse.
-
Assessment of chemotherapy-induced peripheral neuropathy across multiple centers
This study is trying to understand how chemotherapy affects nerve function and quality of life in patients with chemotherapy-induced peripheral neuropathy by using different tests and measures.
-
Evaluating the effects of cinnamaldehyde and capsaicin on blood flow in patients with chemotherapy-induced peripheral neuropathy
This study tests if applying cinnamaldehyde and capsaicin on the skin can improve blood flow in patients with chemotherapy-induced peripheral neuropathy and healthy volunteers.
-
Using ozone therapy to treat pain from chemotherapy-induced nerve damage
This study is testing whether ozone therapy can help cancer patients who have ongoing pain from chemotherapy-induced nerve damage feel better.
NIH-funded research (newest 40 of 41)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
-
Longitudinal study of how body-sense relates to chemotherapy nerve damage
This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.
-
A new screen for chemotherapy-related nerve problems in young children
A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.
-
How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
-
Axonal transport and chemotherapy-related nerve pain
This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.
-
Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy
A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.
-
Non-opioid pain relief for chemotherapy-related nerve pain using CART II
A study tests a brain-acting peptide called CART II to help reduce pain from chemotherapy-induced nerve damage without opioids.
-
New oral TAK1 inhibitor to help with chemotherapy-related nerve pain
A new oral drug candidate aims to prevent or lessen nerve damage and pain caused by certain chemotherapy treatments in cancer patients.
-
Remotely Delivered Tai Chi to Help Older GI Cancer Patients with Chemotherapy-Related Nerve Pain
A study will test a home-based Tai Chi program to ease nerve pain and improve function for GI cancer patients aged 65 and older who are experiencing chemotherapy-related neuropathy.
-
Non-invasive microscopic biomarkers to track chemotherapy-caused nerve pain
A study at the University of Arizona will test a non-invasive imaging method to visualize tiny nerve endings in the skin to help understand and monitor chemotherapy-induced peripheral neuropathy in cancer patients.
-
New ways to prevent and reverse chemotherapy-related nerve damage
Researchers are trying approaches that block a nerve‑destroying protein to prevent or reverse painful nerve damage in people treated with chemotherapy.
-
Skin nerve–immune links in chemotherapy-related hand and foot nerve pain
This project looks at how interactions between skin nerves and the immune system may cause long-lasting hand and foot nerve pain after the chemotherapy drug oxaliplatin.
-
Blocking NLRP3 to treat paclitaxel-related nerve pain
This project looks at whether blocking the NLRP3 inflammasome can help adults who get nerve pain from paclitaxel chemotherapy.
-
SP16 to prevent chemotherapy-related nerve damage
This project tries to prevent or reduce nerve pain and lasting nerve damage from taxane chemotherapy using a new drug called SP16 that activates the LRP1 receptor.
-
How the brain's sensing of the body affects chemo-related nerve symptoms
Researchers will follow people with breast or gastrointestinal cancer getting taxane or platinum chemotherapy and healthy volunteers to learn whether changes in the brain's body-sensing relate to nerve symptoms after chemotherapy.
-
How immune cells in women might protect against nerve pain from chemotherapy
This project explores how certain immune cells in female bodies may naturally reduce nerve pain caused by chemotherapy, aiming to find new ways to prevent this side effect.
-
New treatments for nerve pain caused by chemotherapy
This study is looking for new medications to help manage nerve pain that some people experience after chemotherapy, focusing on a protein called CRMP2, with the hope of finding safer treatments that don't involve opioids.
-
Managing nerve pain caused by chemotherapy through remote monitoring
This study is testing a new way to help people who have painful nerve issues after chemotherapy by using a symptom reporting tool and follow-up calls from nurses to make sure they get the support they need.
-
New methods to detect nerve damage from chemotherapy
This study is looking at a new way to see and measure nerve damage in the skin caused by chemotherapy, which can help doctors better understand and manage the symptoms for cancer patients dealing with nerve pain.
-
Mobile app teaching caregivers massage techniques for chemotherapy-related nerve pain
This study is creating a friendly mobile app called 'Peripheral Neuropathy Relief' to help caregivers learn easy massage techniques that can ease the discomfort of cancer survivors dealing with nerve pain from chemotherapy.
-
Understanding and treating nerve damage from chemotherapy
This project looks at how chemotherapy causes nerve damage in cancer patients.
-
Antibody-based treatment for nerve pain from oxaliplatin chemotherapy
This project tests a small engineered antibody-like drug to relieve long-lasting nerve pain in people treated with oxaliplatin chemotherapy.
-
Understanding how aging cells contribute to nerve pain after chemotherapy
This study is looking at how certain aging cells in the body might cause the painful nerve problems that some cancer survivors experience after chemotherapy, with the hope of finding new ways to help manage or prevent these symptoms.
-
Spinal cord stimulation for nerve pain from chemotherapy and better cancer treatment
This project explores how spinal cord stimulation might reduce nerve pain caused by chemotherapy and improve the effectiveness of cancer drugs.
-
Investigating a new treatment for pain caused by chemotherapy
This study is looking at a new treatment called CART II to help relieve the painful nerve issues that some cancer patients experience after chemotherapy, and it aims to find a safer way to manage that pain for everyone.
-
Acupuncture to ease chemotherapy-related nerve pain
This project tests whether real acupuncture, compared with sham acupuncture, reduces moderate-to-severe chemotherapy-related nerve pain in cancer survivors.
-
A new treatment to prevent nerve damage from chemotherapy
This study is testing a new drug called SP16 to see if it can help prevent the painful nerve damage that some cancer survivors experience after chemotherapy, making life a little easier for those who have gone through treatment.
-
Using yoga to help relieve pain from chemotherapy-induced nerve damage
This study is looking at whether an eight-week yoga program can help ease the pain and improve the quality of life for cancer survivors dealing with nerve pain from chemotherapy, and it’s open to people who want to try a natural way to feel better.
-
Targeting a specific protein to reduce nerve damage from chemotherapy
This study is looking at whether blocking a specific protein can help reduce the painful nerve damage that some cancer patients experience from chemotherapy, with the hope of making their treatment more comfortable and improving their quality of life.
-
Understanding how nerve and immune interactions in the skin contribute to nerve damage from chemotherapy.
This study is looking into how chemotherapy, especially the drug oxaliplatin, can cause painful nerve damage in cancer patients, and it aims to understand how nerve and immune cells in the skin work together to create this problem, with hopes of finding better ways to help manage the pain.
-
Finding ways to treat nerve damage caused by chemotherapy
This study is looking for ways to help cancer patients who experience painful nerve damage from chemotherapy, by using a special virus to deliver treatments that can protect their nerves and improve their comfort during and after treatment.
-
Creating a new survey to detect nerve damage from chemotherapy in young children
This study is creating a new survey to help find out if young children with leukemia are experiencing nerve pain from their chemotherapy, so we can better support their health and well-being after treatment.
-
Understanding how certain immune cells help reduce pain in women undergoing chemotherapy
This study is looking at how certain immune cells might help reduce pain from chemotherapy in women, and it aims to find out how these cells work with nerve cells and are affected by hormones, so we can improve pain relief for women during cancer treatment.
-
Protecting nerves from damage caused by chemotherapy
This study is looking at how a drug called Fluocinolone acetonide might help prevent painful nerve damage from chemotherapy, especially for those receiving a common treatment called Paclitaxel, so patients can feel better while getting their cancer care.
-
Using spinal cord stimulation to reduce pain from chemotherapy
This study is looking at how spinal cord stimulation might help relieve the pain caused by chemotherapy-induced peripheral neuropathy, which many cancer patients experience, and aims to find ways to make this treatment even more effective.
-
Understanding how body sensations affect nerve pain from chemotherapy
This study is looking at how chemotherapy affects nerve pain and how your brain senses these feelings, and it's for people with breast or gastrointestinal cancer who are getting treatment, as well as some healthy individuals for comparison.
-
Using duloxetine to prevent nerve damage from chemotherapy in cancer patients
This study is looking at whether the medication duloxetine can help prevent numbness and tingling in the hands and feet caused by oxaliplatin treatment in people with colorectal cancer, and it will involve patients from different locations to see how well it works.
-
How immune cells interact with nerve cells in chemotherapy-related nerve damage
This study is looking at how immune cells and pain-sensing nerve cells work together in people who have pain from chemotherapy, to find new ways to help manage that pain.
-
Predicting nerve damage from chemotherapy in cancer patients
This study is looking for a way to predict if patients will experience painful nerve issues from the cancer drug oxaliplatin by tracking their sensitivity to cold through a mobile app, making it easier to personalize treatments and help improve their comfort during chemotherapy.
-
Evaluating the effects of cannabis compounds on nerve pain from chemotherapy
This study is looking at whether CBD and THC can help cancer survivors who have nerve pain from chemotherapy feel better, and if you join, you might receive one of these treatments or a placebo over eight weeks to see how it helps with symptoms like tingling and pain.
Related topics
Quick answers
How many Chemotherapy-induced Peripheral Neuropathy clinical trials are recruiting right now?
36, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 25 countries. The most sites are in United States (17 trials), Spain (3 trials), Italy (3 trials), Denmark (3 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 4, Phase 2/3: 2, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.