Condition

Colorectal Carcinoma clinical trials and research

• 47Clinical trials
• 6NIH research projects
• 19Countries

Newest Colorectal Carcinoma clinical trials

All recruiting trials (47)

• Exercise after pelvic radiation to see if it lowers colorectal cancer risk

  This study tests whether regular walking therapy after pelvic radiation for prostate cancer can influence markers of colorectal cancer in colon tissue and blood.

  Recruiting at 2 sites City of Hope Medical Center · Duarte, California and 1 other locations · NCT07790718

• Irreversible Electroporation for Recurrent Pelvic Tumors

  This study tests whether using irreversible electroporation (IRE) is safe and helps control recurrent pelvic tumors in adults who can’t have other local treatments.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT07782164

• Smart Symptom Tracking with ALEX for GI Health in Young Adults

  This trial tests whether the Smart Symptom Tracking ALEX app can better track GI symptoms in young adults (18–44) compared with standard paper logs.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07618273

• Culturally adapted online genetic counseling and testing education for African American cancer survivors

  We will test a culturally adapted online genetic counseling program to see if it increases genetic counseling and genetic testing among African American breast, prostate, and colorectal cancer survivors.

  Recruiting Barbara Ann Karmanos Cancer Institute · Detroit, Michigan · NCT07436078

• Zanidatamab given before surgery for HER2-positive colon or rectal cancer

  This tests whether giving zanidatamab before surgery helps adults with HER2-positive, RAS‑wildtype colon or rectal cancer who are planned for curative treatment.

  Recruiting at 4 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT07405476

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Zanidatamab for solid tumors with HER2 changes

  This study will try zanidatamab, an anti-HER2 drug, in adults with advanced endometrial, colorectal, head and neck, sarcoma, or non-small cell lung cancer whose tumors have specific HER2 changes.

  Recruiting at 2 sites Phase 2 Unicancer · Angers and 3 other locations · NCT07192068

• Rectus sheath catheters after midline abdominal surgery

  This study tests whether using rectus sheath catheters with local anesthetic provides better pain relief after midline laparotomy compared with a placebo in adults.

  Recruiting Asklepios Kliniken Hamburg GmbH · Schwedt, Brandenburg · NCT07099924

• p16 protein expression in colorectal cancer and its links to clinical and pathological features

  This project will test whether p16 protein levels and staining patterns in tumor tissue from people with colorectal cancer link to features such as age, tumor site, histologic type, lymph node status, and nerve or vessel invasion.

  Recruiting Sohag University · Sohag, Recruiting · NCT07047482

• Blood markers to better sort who needs urgent colorectal testing

  This will test whether a blood test measuring hPG80 and mobile genetic elements can spot colorectal cancer or polyps in adults referred for urgent bowel investigations.

  Recruiting Queen Mary University of London · London, England · NCT07035691

• CP-383 for advanced or metastatic solid tumors

  This trial tests whether the oral drug CP-383 can slow or stop growth in adults with advanced or metastatic solid tumors who have exhausted standard treatments.

  Recruiting at 13 sites Phase 1/2 Tasca Therapeutics · Denver, Colorado and 12 other locations · NCT07030257

• Vanguard: a new blood test approach to screen for multiple cancers

  This study will test two different blood-based multi-cancer detection tests in adults 45–75 without cancer to see if they find cancers earlier than usual care.

  Recruiting at 46 sites National Cancer Institute (NCI) · Pleasanton, California and 45 other locations · NCT06995898

• Preserving the rectum in patients with rectal cancer using targeted radiation therapy

  This study is testing if targeted radiation therapy can help patients with rectal cancer avoid surgery while still keeping their cancer under control.

  Recruiting Phase 2 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT06991465

• CAR-T therapy targeting CDH17 for advanced solid tumors

  This study is testing a new CAR-T cell therapy aimed at treating advanced solid tumors that have a specific marker called CDH17 in patients who have run out of other treatment options.

  Recruiting Early Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT06937567

• Comparing two pain relief methods for open colon surgery

  This study is testing whether a single dose of spinal morphine or continuous epidural pain relief works better for managing pain after open colon surgery for cancer patients.

  Recruiting Phase 4 University Hospital of Split · Split · NCT06935708

• Evaluation of a new robotic surgical system for major gastrointestinal and urologic surgeries

  This study is testing a new robotic surgery system to see if it can safely and effectively help patients with major gastrointestinal and urologic conditions like colorectal and prostate cancer.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06926374

• Blood test for early diagnosis of colorectal cancer

  This study is testing a new blood test to see if it can help find colorectal cancer and advanced polyps earlier in people who are at risk.

  Recruiting at 4 sites Advanced Marker Discovery S.l. · Zaragoza, Aragon and 8 other locations · NCT06889883

• Short-course radiation plus CAPEOX chemotherapy and serplulimab for MSS/pMMR rectal cancer with limited metastases

  This trial will try combining short-course radiotherapy, CAPEOX chemotherapy, and the immunotherapy serplulimab to see if it helps people with MSS/pMMR rectal cancer who have a small number of metastases.

  Recruiting Phase 2 First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06850103

• Multilevel approach to boost follow-up colonoscopy after abnormal FIT

  This trial tests a multilevel program to help people with abnormal FIT results complete a follow-up colonoscopy.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT06822530

• Testing MGC028 in patients with advanced solid tumors

  This study is testing a new treatment called MGC028 to see if it is safe and can help adults with advanced solid tumors that can't be removed or have spread.

  Recruiting at 7 sites Phase 1 MacroGenics · San Francisco, California and 6 other locations · NCT06723236

• Evaluating PreveCol for Early Detection of Colorectal Cancer

  This study is testing a new blood test called PreveCol to see if it can help find colorectal cancer and advanced polyps in people aged 50-69 who have already had a positive stool test.

  Recruiting Advanced Marker Discovery S.l. · Lisbon, Lisbon District and 1 other locations · NCT06703632

• Digital system to improve postoperative care for colorectal cancer patients

  This study tests a digital follow-up platform for adults who had colorectal cancer surgery to see if it improves how well they stay in touch with care and feel supported.

  Recruiting RenJi Hospital · Shanghai · NCT06685497

• Improving colorectal cancer screening in primary care clinics

  This study is testing two different ways to improve colorectal cancer screening rates in primary care clinics to see which one helps more people get screened.

  Recruiting University of Kansas Medical Center · Aurora, Colorado · NCT06682650

• Program to increase cancer screening among low-income women in Central Ohio

  This study is trying to see if a new program can help low-income women in Central Ohio get better access to cancer screenings for breast, cervical, and colorectal cancers.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06666192

• Treatment model for colorectal cancer using ambulatory surgery

  This study tests whether a less invasive day surgery for colorectal cancer can lead to fewer complications and better long-term results for generally healthy patients compared to traditional surgery.

  Recruiting First Hospital of China Medical University · Shenyang, Liaoning · NCT06637215

• Combination treatment for advanced colorectal cancer with BRAF V600E mutation

  This study is testing a new combination treatment for advanced colorectal cancer with a specific mutation to see if it works better than the usual treatment.

  Recruiting Phase 2 Shanghai Changzheng Hospital · Shanghai · NCT06603376

• Primary Care–GI Connect to improve colonoscopy follow-up after an abnormal FIT

  This trial tests whether a clinic-wide Primary Care–GI Connect program helps patients at community health centers get colonoscopies within six months after an abnormal fecal immunochemical test (FIT).

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California and 1 other locations · NCT06568016

• TPST-1495 treatment for people with familial adenomatous polyposis

  This trial will try an oral drug called TPST-1495 to see if it reduces the number of polyps in the small bowel and colon in people with familial adenomatous polyposis.

  Recruiting at 2 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 3 other locations · NCT06557733

• Examining the effects of cannabis use in cancer patients undergoing treatment

  This study is trying to see how using cannabis affects newly diagnosed cancer patients who are starting treatment for their illness.

  Recruiting at 491 sites Wake Forest University Health Sciences · Fairbanks, Alaska and 490 other locations · NCT06418204

• Improving colonoscopy follow-up for patients with high risk colon polyps

  This study is testing whether better reminders and support for scheduling can help patients with high risk colon polyps get their follow-up colonoscopies done on time to lower their chances of developing colorectal cancer.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06376565

• T cell therapy targeting KRAS G12D in advanced solid tumors

  This trial will test whether autologous T cells engineered to recognize KRAS G12D can help adults with unresectable or metastatic solid tumors who have the matching HLA type.

  Recruiting at 18 sites Phase 1 AstraZeneca · Duarte, California and 17 other locations · NCT06218914

• Activating the immune response to treat advanced colorectal and breast cancer

  This study is testing a new immune treatment combined with radiation to see if it can help people with advanced colorectal or breast cancer that can't be surgically removed.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06130826

• Understanding colorectal cancer in Hispanic patients

  This study looks at Hispanic patients with colorectal cancer to see how their genes and gut health affect their treatment and outcomes.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06063928

• Treatment with engineered T cells for advanced solid tumors with a specific mutation

  This study is testing a new T cell therapy for patients with advanced solid tumors that have a specific mutation to see if it can help fight their cancer.

  Recruiting at 16 sites Phase 1 AstraZeneca · Gilbert, Arizona and 19 other locations · NCT05877599

• Evaluating BDTX-4933 for patients with specific cancer mutations

  This study is testing a new drug called BDTX-4933 to see if it can help adults with advanced cancers that have certain gene mutations feel better and improve their treatment options.

  Recruiting at 34 sites Phase 1/2 Servier · Gilbert, Arizona and 48 other locations · NCT05786924

• Web-based support for colorectal cancer patients and their caregivers

  This study is testing a new online support program to help colorectal cancer patients and their caregivers manage symptoms like fatigue and depression during chemotherapy.

  Recruiting Emory University · Atlanta, Georgia · NCT05663203

• ONC201 (dordaviprone) for safety and prevention of colorectal polyps in high-risk adults.

  This trial tests whether different doses of ONC201 (dordaviprone) are safe and can help prevent new colorectal polyps in adults with familial adenomatous polyposis or a history of multiple adenomas.

  Recruiting at 3 sites Phase 1 National Cancer Institute (NCI) · Ann Arbor, Michigan and 4 other locations · NCT05630794

• Improving colorectal cancer screening in Black and underserved communities in Phoenix

  This study is trying to improve colorectal cancer screening for Black and underserved communities in Phoenix by offering free at-home tests and support to help people get the care they need.

  Recruiting Mayo Clinic · Scottsdale, Arizona · NCT05447923

• Collecting blood and stool samples to detect colorectal cancer in Lynch syndrome patients

  This study is testing a new stool DNA test to see if it can help find colorectal cancer in people with Lynch syndrome by collecting their blood and stool samples.

  Recruiting at 7 sites Mayo Clinic · Scottsdale, Arizona and 8 other locations · NCT05410977

• Using PD-1 antibody for treating advanced colorectal cancer

  This study is testing if a PD-1 antibody can help people with advanced colorectal cancer that has certain genetic features stay cancer-free after surgery, compared to a standard chemotherapy combination.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou · NCT05236972

• Neoantigen vaccine combined with nivolumab for liver cancer treatment

  This study is testing a personalized vaccine combined with a cancer drug to see if it can help people with liver cancer stay cancer-free after surgery.

  Recruiting Phase 2 National Cancer Centre, Singapore · Singapore · NCT04912765

• Tegavivint treatment for recurrent or refractory solid tumors in children

  This study tests if a new intravenous medication called tegavivint can help children with tough-to-treat solid tumors, like Ewing sarcoma and desmoid tumors, by finding the right dose and seeing how well it works.

  Recruiting at 19 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 20 other locations · NCT04851119

• Impact of cancer treatments on reproductive and sexual health in young colorectal cancer patients

  This study looks at how chemotherapy and radiation therapy affect the reproductive and sexual health of young people with early onset colorectal cancer.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT04812912

• Understanding how diet influences the gut microbiome and colorectal cancer risk

  This study looks at how different diets, like vegetarian or omnivore, affect the gut bacteria and the risk of developing colorectal cancer.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04666727

• Understanding young onset colorectal cancer

  This study is trying to gather information from people with colorectal cancer to see how cases in younger patients under 50 are different from those diagnosed after 50.

  Recruiting at 8 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT04489238

• A wait-and-see approach for rectal cancer patients after treatment

  This study is testing whether some rectal cancer patients who respond well to treatment can safely skip surgery and just be closely monitored instead.

  Recruiting at 2 sites McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec and 1 other locations · NCT03001362

• Identifying biomarkers and treatment strategies for peritoneal surface malignancies

  This study is trying to find specific markers in patients with peritoneal surface cancers to help choose the best treatment options and improve their chances of recovery.

  Recruiting Oslo University Hospital · Oslo · NCT02073500

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• BVES protein in colorectal cancer: stopping tumor spread by stabilizing cell junctions

  This grant explores how BVES, a protein at cell junctions, prevents colorectal cancer cells from becoming more aggressive and how restoring BVES could lead to new ways to stop tumor growth.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11412317

• Ensemble deep learning to detect tumor buds and judge risk in colorectal cancer

  A computer tool will help doctors identify tumor buds in colorectal cancer slides and use that information to better estimate a patient’s prognosis.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11369668

• extracellular RNA in colorectal cancer: how RNAs travel between cells and impact tumors

  A broad research program at Vanderbilt is studying how extracellular RNAs travel between cancer cells in colorectal cancer and influence tumor growth and treatment response.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11265208

• Using AI to Improve Colorectal Cancer Prognosis

  This project is creating a smart computer system to find tiny groups of cancer cells in colon tissue, helping doctors better understand a patient's colorectal cancer.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11128528

• Using deep learning to detect tumor buds in colorectal cancer.

  This study is working on a smart computer program that helps doctors spot tiny signs of tumor growth in colorectal cancer, which can help predict how well patients might do, so they can make better treatment choices.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10833509

• Understanding how RNA communication affects colorectal cancer

  This study is looking at how tiny pieces of RNA found outside of cells might affect the growth and spread of colorectal cancer, with the hope that understanding this could lead to new treatments for patients.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-10759428

Related topics

Quick answers

How many Colorectal Carcinoma clinical trials are recruiting right now?

47, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (28 trials), China (8 trials), Spain (3 trials), Canada (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1: 5, Phase 1/2: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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