Condition

Esophageal Carcinoma clinical trials and research

• 22Clinical trials
• 10Countries

Newest Esophageal Carcinoma clinical trials

All recruiting trials (22)

• Paclitaxel given inside the abdomen with systemic therapy for GI cancers with peritoneal spread

  This phase II study tests a combination of intraperitoneal and systemic chemotherapy (paclitaxel) in adults with digestive tract cancers that have spread to the peritoneum.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07795749

• Impact of Surgical Treatment on Survival in Localized Small Cell Esophageal Cancer

  This study looks at whether surgery improves survival for people with localized small cell esophageal cancer compared with non-surgical treatment.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT07596654

• Postoperative Low Oxygen and Chance of Leaks After Esophageal Surgery

  This study looks at whether low oxygen levels after esophageal cancer surgery increase the chance of an anastomotic leak.

  Recruiting at 6 sites Sun Yat-sen University · Guangzhou, Guangdong and 5 other locations · NCT07309991

• Using the PAGODA algorithm to guide FOLFOX dose changes and reduce unplanned chemotherapy delays

  This trial will test whether using the PAGODA algorithm to guide dose changes during FOLFOX chemotherapy for people with gastrointestinal cancers can reduce unplanned treatment delays.

  Recruiting at 391 sites Alliance for Clinical Trials in Oncology · Fairbanks, Alaska and 397 other locations · NCT07283939

• Indocyanine green to highlight tumor depth and margins during endoscopic removal of esophageal or stomach cancer

  This trial will test whether a dye called indocyanine green can help doctors see the depth and edges of superficial esophageal or stomach cancers during endoscopic submucosal dissection.

  Recruiting Phase 1/2 University Medical Center Groningen · Groningen, Provincie Groningen · NCT07108855

• Best time for minimally invasive local treatment after first-line systemic therapy for limited (oligo) esophageal or stomach cancer

  This trial will test whether giving local treatment (surgery or radiation) earlier or later after first-line systemic therapy works better for people whose esophageal or stomach cancer has spread to only a few sites.

  Recruiting at 4 sites Phase 2 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam and 4 other locations · NCT07000253

• Vanguard: a new blood test approach to screen for multiple cancers

  This study will test two different blood-based multi-cancer detection tests in adults 45–75 without cancer to see if they find cancers earlier than usual care.

  Recruiting at 46 sites National Cancer Institute (NCI) · Pleasanton, California and 45 other locations · NCT06995898

• Radiotherapy followed by immunotherapy for advanced esophageal cancer

  This study is testing if a new type of radiation therapy followed by an immune-boosting treatment can help adults with advanced esophageal cancer feel better and improve their health.

  Recruiting Phase 3 Fudan University · Shanghai · NCT06964568

• Prehabilitation with exercise and nutrition before esophagectomy for esophageal cancer

  This program will test if exercise plus nutrition before esophagectomy is doable and acceptable for adults with esophageal cancer.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06872515

• Combining immunotherapy with targeted radiotherapy and chemotherapy for advanced esophageal cancer

  This study is testing if adding immunotherapy to a combination of targeted radiotherapy and chemotherapy can help people with advanced esophageal cancer feel better and improve their treatment results.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT06676449

• Imaging study using two antibody fragments in patients with solid tumors

  This study is testing two special antibody fragments in people with solid tumors to see how well they target cancer cells and how they move through the body.

  Recruiting Early Phase 1 Var2 Pharmaceuticals · Groningen, Provincie Groningen · NCT06645808

• Combining Serplulimab with Chemoradiotherapy for Elderly Patients with Advanced Esophageal Cancer

  This study is testing if combining a new drug called Serplulimab with standard chemotherapy and radiation can help older patients with advanced esophageal cancer who can't have surgery feel better and live longer.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06354218

• Comparing home and clinic administration of nivolumab for cancer treatment

  This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT06265285

• Treatment of Taxane-resistant Cancers with Paclitaxel Polymeric Micelles

  This study is testing a new form of chemotherapy called Paclitaxel Polymeric Micelles to see if it can help people with advanced cancers that didn't respond to standard Taxane treatments.

  Recruiting Phase 2 Tongji Hospital · Wuhan, Hubei · NCT06199895

• Using amiodarone to prevent atrial fibrillation after esophageal cancer surgery

  This study is testing if the heart medication amiodarone can help prevent atrial fibrillation in patients recovering from esophageal cancer surgery.

  Recruiting Phase 2 OHSU Knight Cancer Institute · Portland, Oregon · NCT06067438

• Assessing minimal residual disease in esophageal cancer patients

  This study is testing how treatment affects leftover cancer cells in patients with advanced esophageal cancer to see if it helps predict how well the treatment is working.

  Recruiting Hebei Medical University Fourth Hospital · Shijiazhuang, Hebei · NCT05952661

• Combining postoperative radiotherapy and immunotherapy for advanced esophageal cancer

  This study is testing if combining radiation therapy with immunotherapy after surgery can help people with advanced esophageal cancer live longer and have fewer side effects.

  Recruiting Phase 1/2 Anhui Provincial Hospital · Hefei, Anhui · NCT05937438

• Evaluating heart damage from radiation in lung and esophageal cancer patients

  This study is testing how radiation treatment for lung and esophageal cancer affects the heart and aims to find ways to reduce heart damage during therapy.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT05775939

• Observing cancer recurrence using a blood test

  This study is testing a new blood test to see if it can help find out if cancer comes back in people who have been treated for early-stage solid tumors.

  Recruiting at 49 sites Guardant Health, Inc. · Birmingham, Alabama and 56 other locations · NCT05059444

• Comparing robot-assisted and open surgery for esophageal cancer

  This study is testing if robot-assisted surgery for esophageal cancer is as effective or better than traditional open surgery in helping patients recover and live well after the operation.

  Recruiting Hospital Universitari de Bellvitge · L'Hospitalet de Llobregat, Barcelona · NCT04652180

• Yoga intervention to improve physical performance and quality of life for cancer patients and their caregivers

  This study tests whether a yoga program can help improve physical performance and quality of life for cancer patients and their caregivers during radiotherapy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03948100

• Collecting data on side effects of proton therapy for cancer treatment

  This study is trying to learn about the side effects that cancer patients experience after receiving proton therapy to help improve future treatments.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT00991094

Related topics

Quick answers

How many Esophageal Carcinoma clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (10 trials), China (8 trials), Spain (3 trials), Netherlands (3 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 2, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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