Improving genetic counseling for at-risk relatives of cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates whether provider-mediated communication of genetic testing results can enhance genetic counseling and testing rates among at-risk relatives of cancer patients. Participants are randomized into two groups: one receives a family letter and genomic test report, while the other receives the same materials along with direct provider contact to discuss the genetic results. The study aims to improve cascade testing rates and assess the psychosocial impact of this communication method. It targets individuals with inherited cancer risk due to pathogenic gene variants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* PATIENTS: Enrolled in City of Hope (COH) institutional review board (IRB) 07047 or have been seen by COH Genetics for genetic testing
* PATIENTS: Have an pathogenic/ likely pathogenic germline variant
* PATIENTS: Fluent in English
* PATIENTS: Age \>= 18 years
* PATIENTS: Willing to provide contact information for eligible first-degree relatives
* PATIENTS: \>= 2 first-degree relatives that are eligible for genetic testing and reside in the United States of America
* FIRST-DEGREE RELATIVES: Proband is a COH patient and has consented to this study
* FIRST-DEGREE RELATIVES: First-degree relative of proband
* FIRST-DEGREE RELATIVES: Resides within the United States
* FIRST-DEGREE RELATIVES: Has not undergone genetic testing for the known familial variant
* FIRST-DEGREE RELATIVES: Are fluent in English
* FIRST-DEGREE RELATIVES: Age \>= 18 years

Exclusion Criteria:

* PATIENTS: Unable to provide informed consent
* PATIENTS: =\< 2 at-risk first-degree relatives who are eligible for genetic testing and/or reside within the United States
* PATIENTS: Unwilling to provide contact information for family members
* FIRST-DEGREE RELATIVES: Unable or unwilling to provide informed consent
* FIRST-DEGREE RELATIVES: Have undergone genetic testing for the known familial variant
* FIRST-DEGREE RELATIVES: Resides outside of the United States

Where it's running

• City of Hope Medical Center
  Duarte, California, United States Recruiting

Study contacts

• Principal investigator: Stacy W Gray — City of Hope Medical Center

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.