Condition

Leukemia clinical trials and research

• 96Clinical trials
• 546NIH research projects
• 22Countries

Newest Leukemia clinical trials

All recruiting trials (96)

• Genetics of Blood Cancers in the U.S. population

  This study tests how genetic factors relate to blood cancers by collecting saliva DNA and online health surveys from at least 10,000 U.S. adults.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07714044

• Strength Training for Kids with Acute Lymphoblastic Leukemia and Lymphoblastic L lymphoma

  Researchers are testing a structured strength-training program for children and teens recently diagnosed with ALL or lymphoblastic lymphoma to see if it helps with weight gain and physical function during treatment.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07634653

• Cord blood transplant for children and young adults with blood cancers.

  This study will test whether a cord blood transplant given as a first or second transplant can help children and young adults with leukemia, myelodysplasia, or lymphoma who lack a matched donor.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT07566377

• Cohort for people with chronic myelomonocytic leukemia

  This project will collect blood and bone marrow samples from adults with chronic myelomonocytic leukemia at diagnosis and during disease changes to create an anonymized biobank researchers can use to test new questions.

  Recruiting Gustave Roussy, Cancer Campus, Grand Paris · Amiens and 23 other locations · NCT07512882

• Triple-drug approach for AML using eganelisib with azacitidine and venetoclax

  This early-stage trial tests whether adding eganelisib to azacitidine and venetoclax can be safe and show signs of benefit in adults with acute myeloid leukemia.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07439211

• Guided spiritual care sessions for adults with acute leukemia

  This will test whether adding guided spiritual care sessions helps adults hospitalized for initial treatment of acute leukemia compared with standard inpatient spiritual care.

  Recruiting University of Chicago · Chicago, Illinois · NCT07405424

• Revumenib with Mezigdomide for relapsed or refractory acute leukemia

  This trial will test whether combining revumenib and mezigdomide is safe for people aged 12 and older with relapsed or refractory acute leukemia that has KMT2A, NUP98, or NPM1 genetic changes.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Duarte, California and 9 other locations · NCT07356154

• CG009301 for adults with relapsed or treatment‑resistant blood cancers

  This trial will try a new drug called CG009301 to see if it's safe and helps adults whose leukemia or related blood cancers have come back or not responded to prior treatment.

  Recruiting at 3 sites Phase 1 Cullgen (Shanghai),Inc · Nanchang and 2 other locations · NCT07347171

• Capivasertib plus venetoclax with low-intensity chemotherapy for adults with lymphoid acute leukemia or lymphoblastic lymphoma

  This will see if adding capivasertib to venetoclax and a low‑intensity chemotherapy regimen helps adults with relapsed or refractory lymphoid acute leukemia or lymphoblastic lymphoma.

  Recruiting Phase 1/2 University of Chicago · Chicago, Illinois · NCT07294677

• See if a behavioral coaching plus at-home exercise can help older blood cancer survivors slow aging

  Aimed at people 50 and older who have had a blood cancer, this trial tests whether combining coaching with a virtual exercise program can help slow aging and improve health.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT07292272

• Reduced‑dose apixaban or rivaroxaban versus daily low‑molecular‑weight heparin for people with blood cancers

  This trial will test whether reduced‑dose apixaban or rivaroxaban pills can prevent blood clots as well and as safely as daily low‑molecular‑weight heparin injections in people with hematologic malignancies.

  Recruiting Medical University of Gdansk · Gdansk, Pomeranian Voivodeship · NCT07270263

• Dose-adjusted EPOCH infusions for frail adults with acute lymphoblastic leukemia

  This project will see if a dose-adjusted, infusion-based EPOCH chemotherapy regimen helps frail adults with acute lymphoblastic leukemia tolerate treatment better and live longer.

  Recruiting Hospital General de Mexico · Mexico City, Mexico City · NCT07258043

• Low-dose post-transplant cyclophosphamide plus tacrolimus and ruxolitinib to prevent GVHD after myeloablative peripheral blood stem cell transplant

  This test sees if adding low-dose post-transplant cyclophosphamide with tacrolimus and ruxolitinib can reduce severe acute graft-versus-host disease in adults receiving myeloablative peripheral blood stem cell transplants for leukemia or myelodysplasia.

  Recruiting at 3 sites Phase 2 Ohio State University Comprehensive Cancer Center · Birmingham, Alabama and 2 other locations · NCT07249346

• ALL Backbone in AYAs

  Aims to see if a chemotherapy regimen can safely and effectively treat newly diagnosed Philadelphia chromosome-negative ALL in adolescents and young adults.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07227584

• High-altitude stem cell and bone marrow transplant registry on the Qinghai-Tibet Plateau

  This project will collect clinical data and blood/bone marrow samples from people having hematopoietic stem cell transplants on the Qinghai‑Tibet Plateau to see how high altitude affects transplant outcomes and recovery.

  Recruiting Affiliated Hospital of Qinghai University · Xining, Qinghai · NCT07205523

• Stopping immunoglobulin replacement with or without antibiotics to prevent infections in blood cancer patients

  This trial tests if stopping immunoglobulin replacement, with or without daily preventive antibiotics, is safe and keeps infections low in people with myeloma, leukemia, or non-Hodgkin's lymphoma who have been on Ig therapy.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202091

• Preventing infections in people with blood cancers using antibiotics or immunoglobulin

  This project tests whether giving regular intravenous immunoglobulin or prophylactic antibiotics better prevents infections in people with myeloma, non-Hodgkin lymphoma, or leukemia who have not yet started immunoglobulin replacement.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202078

• Antibiotics versus immunoglobulin to prevent infections in people with blood cancers

  This trial tests whether taking preventive antibiotics instead of regular IV immunoglobulin can prevent infections in people with myeloma, non-Hodgkin lymphoma, or leukemia.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202065

• Comparing antibiotics and immunoglobulin to prevent infections in blood cancers

  This project tests whether immunoglobulin or antibiotic strategies better prevent infections in adults with blood cancers.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202052

• Targeting measurable residual AML with tagraxofusp plus azacitidine and venetoclax

  This trial tests whether adding tagraxofusp to azacitidine and venetoclax can safely help control measurable residual acute myeloid leukemia (AML) in adults who are in remission but still have detectable disease.

  Recruiting at 2 sites Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07148180

• Blinatumomab plus donor lymphocyte infusion to prevent relapse after transplant in high-risk Ph-negative B‑cell ALL

  This trial tests whether giving blinatumomab together with donor lymphocyte infusions can help prevent relapse in people aged 14–65 with high‑risk Philadelphia chromosome–negative B‑cell acute lymphoblastic leukemia after an allogeneic stem cell transplant.

  Recruiting Phase 2 First Affiliated Hospital of Zhejiang University · Hangzhou · NCT07105579

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• Telehealth music therapy for cognitive difficulties in blood cancer survivors

  This program will test whether telehealth music therapy can help adults who survived leukemia, lymphoma, or myeloma and who are having trouble with memory, attention, or thinking.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07052916

• Mosunetuzumab to clear minimal residual disease in CLL and SLL.

  This trial will try mosunetuzumab, alone or with a BTK inhibitor, to clear minimal residual disease in people with chronic lymphocytic leukemia or small lymphocytic lymphoma.

  Recruiting at 2 sites Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07052695

• Early versus late stopping of antibiotics for adults with high‑risk blood cancers or after stem‑cell or CAR T therapy who develop fever

  This trial tests if stopping antibiotics early is safe for adults with leukemia or after stem‑cell transplant or CAR T therapy when a fever has settled.

  Recruiting at 2 sites Peter MacCallum Cancer Centre, Australia · Melbourne, Victoria and 1 other locations · NCT07051525

• Improving outcomes for stem cell transplant patients using an intervention website

  This study is testing if a special website can help adults with blood cancer feel better and improve their quality of life after a stem cell transplant compared to a regular educational website.

  Recruiting at 3 sites Northwestern University · Washington D.C., District of Columbia and 2 other locations · NCT06960993

• Testing a web application to help patients with acute leukemia

  This study is testing a new web app to see if it can help people with acute leukemia find and join clinical trials more easily.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT06907797

• Comparing ATLG and ATG for immune recovery after allogeneic stem cell transplant

  This study will try using ATLG instead of ATG in adults receiving allogeneic stem cell transplants for blood cancers to see if immune recovery is faster and rates of viral infection or GVHD are lower.

  Recruiting Phase 2/3 Peking University First Hospital · Beijing · NCT06895538

• Treatment of relapsed/refractory acute B-cell leukemia with BiTE-EV

  This study is testing a new treatment called BiTE-EV to see if it can help adults with relapsed or refractory acute B-cell leukemia feel better.

  Recruiting Early Phase 1 Beijing GoBroad Hospital · Beijing · NCT06890494

• Evaluating the risk of blood cancers in firefighters

  This study is testing if firefighters who have been exposed to harmful substances are at a higher risk for blood cancers and related conditions.

  Recruiting Wake Forest University Health Sciences · Charlotte, North Carolina · NCT06870760

• Best germline DNA source to guide drug dosing after allogeneic stem cell transplant

  This project will test whether blood, skin, or other tissue samples give the most reliable genetic information to guide medicine dosing for adults who receive an allogeneic stem cell transplant.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06856226

• Using CD45RA Depleted Stem Cells to Prevent Infections After Transplant

  This study is testing whether using special stem cells can help patients with high-risk leukemia recover their immune system faster and prevent infections after a stem cell transplant.

  Recruiting Phase 1/2 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06839456

• Quizartinib maintenance at two doses for FLT3‑ITD positive AML in first complete remission

  This trial tests whether two different doses of quizartinib can help prevent relapse in adults with FLT3‑ITD positive AML who are in first complete remission and have not had an allogeneic stem cell transplant.

  Recruiting at 50 sites Phase 2 Daiichi Sankyo · Birmingham, Alabama and 63 other locations · NCT06824168

• Prophylaxis with Dalbavancin for Children with High-Risk Leukemia

  This study is testing if giving dalbavancin to children with high-risk leukemia can help prevent serious bacterial infections while they are getting chemotherapy.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06810583

• Air pollution biomarkers in people with COPD, lung cancer, and leukemia

  This project will test whether air pollution-related biomarkers appear in never-smokers with COPD, non-small cell lung cancer, or leukemia compared with healthy volunteers.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 2 other locations · NCT06800586

• Go Wish Game to support advance care planning for adults with cancer or blood cancers

  This project tries the Go Wish Game to help adults with refractory leukemia, lymphoma, multiple myeloma, or advanced solid tumors and their caregivers have end-of-life conversations and complete advance care planning.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT06795815

• Roginolisib with venetoclax and rituximab for relapsed or refractory CLL

  This trial will test whether adding roginolisib to the standard venetoclax plus rituximab treatment helps people with relapsed or refractory CLL get deeper and longer remissions.

  Recruiting Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT06644183

• Combining Venetoclax with Intensive Therapy for Acute Myeloid Leukemia Patients

  This study is testing if adding a drug called Venetoclax to standard chemotherapy can help newly diagnosed acute myeloid leukemia patients who aren't responding well to their initial treatment.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06643962

• Using exercise to enhance immune cell therapy for blood cancer

  This study tests if a short cycling exercise can improve immune cells from healthy donors to help treat blood cancers like leukemia and lymphoma more effectively.

  Recruiting Early Phase 1 University of Arizona · Tucson, Arizona · NCT06643221

• Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues

  This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06580002

• Breath analysis to detect fungal infections in leukemia patients

  This study is testing if analyzing breath samples can help doctors detect fungal infections in leukemia patients who are at high risk due to their treatment.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT06537726

• Testing BH-30236 for relapsed or refractory acute myelogenous leukemia and higher-risk myelodysplastic syndrome

  This study is testing a new drug called BH-30236 to see if it can help adults with relapsed or hard-to-treat acute myelogenous leukemia or higher-risk myelodysplastic syndrome.

  Recruiting at 13 sites Phase 1 BlossomHill Therapeutics · Duarte, California and 12 other locations · NCT06501196

• Home blood transfusions for people with advanced blood cancers in hospice

  The study will test whether offering home blood transfusions to adults with advanced or relapsed blood cancers who are eligible for hospice helps improve quality of life, mood, and end-of-life care.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06487247

• Enhancing diversity in clinical trial enrollment through community engagement

  This study is trying to see if getting feedback from patients and community members can help make clinical trials for blood cancer and leukemia more inclusive and diverse.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT06469307

• Prophylactic use of Tocilizumab to prevent complications after CAR-T therapy

  This study is testing if giving Tocilizumab before or during CAR-T therapy can help prevent serious side effects like cytokine release syndrome and neurotoxicity in patients with B-cell cancers.

  Recruiting Phase 2 Insel Gruppe AG, University Hospital Bern · Bern, Canton of Bern · NCT06430736

• Using Mitoxantrone for Treating Venetoclax Resistant Acute Myeloid Leukemia

  This study is testing if a combination of mitoxantrone, venetoclax, and azacitidine can help people with acute myeloid leukemia who haven't responded to previous treatments.

  Recruiting Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT06429449

• Using a NEWS early warning score to prompt ICU admission for adults receiving intensive chemotherapy or stem cell transplant

  This trial tests whether real-time monitoring with the NEWS early warning score and prompt ICU admission (NEWS ≥ 7) helps adults with leukemia, lymphoma, or multiple myeloma who are receiving intensive chemotherapy or a hematopoietic cell transplant.

  Recruiting at 9 sites University Hospital, Angers · Amiens and 9 other locations · NCT06409767

• Using CD22 CAR T Cells after CD19 CAR T Cells for B Cell Leukemia

  This study is testing if giving CD22 CAR T-cell therapy to children and young adults with tough-to-treat B-cell leukemia after they’ve had another CAR T-cell treatment can be safe and effective.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT06408194

• Using a storybook to explain leukemia to children and reduce parental stress

  This study is testing if a storybook about leukemia can help reduce stress for parents of children who have just been diagnosed with the disease.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06360718

• Combining revumenib with standard chemotherapy and targeted therapy for acute myeloid leukemia

  This study is testing a new treatment combining revumenib with standard chemotherapy and another targeted therapy to see if it helps newly diagnosed patients with a specific type of acute myeloid leukemia.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · New Haven, Connecticut and 1 other locations · NCT06313437

• Evaluating a decision support tool for patients with blood cancers

  This study tests a new tool called PRIME to see if it helps older adults with blood cancers make treatment choices that better match their personal preferences compared to regular care.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06296368

• Return to Work After Hematologic Cancer

  This study tests whether a dedicated return-to-work consultation helps adults with blood cancers who finished treatment to go back to their jobs.

  Recruiting at 4 sites University Hospital, Angers · Angers and 9 other locations · NCT06262789

• Platform for Rare Blood Disorders in Europe

  This study is trying to gather and share information about rare blood disorders across Europe to help researchers understand these conditions better and improve treatment options for patients.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Catalonia · NCT06250595

• Using revumenib to treat leukemia linked to HOX gene upregulation

  This study is testing if a new drug called revumenib can help people aged 12 and older with certain types of leukemia that are linked to specific gene changes.

  Recruiting at 2 sites Phase 2 M.D. Anderson Cancer Center · New York, New York and 1 other locations · NCT06229912

• New treatment to improve cord blood engraftment in children with leukemia after transplant

  This study is testing a new treatment to see if it can help children with leukemia have better success with cord blood transplants after their treatment.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06155188

• CIML NK cells combined with venetoclax for treating acute myeloid leukemia

  This study is testing a new treatment using special immune cells and a medication to see if it can help people with acute myeloid leukemia feel better.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06152809

• CIML NK cell therapy to prevent relapse after stem cell transplant

  This study is testing if a new type of immune cell therapy can help prevent relapse in people with certain blood cancers after they receive a stem cell transplant.

  Recruiting Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06138587

• Study of crushed venetoclax tablets dissolved in liquid for pediatric patients

  This study tests if crushing venetoclax tablets and mixing them with liquid helps children with blood cancers absorb the medication better and stay safe while taking it.

  Recruiting at 5 sites Children's Hospital Medical Center, Cincinnati · Aurora, Colorado and 5 other locations · NCT06131801

• Examining the safety of ziftomenib combinations for patients with relapsed acute myeloid leukemia

  This study is testing if combining ziftomenib with standard treatments can safely help people with relapsed acute myeloid leukemia feel better and improve their chances of recovery.

  Recruiting at 43 sites Phase 1 Kura Oncology, Inc. · Gilbert, Arizona and 44 other locations · NCT06001788

• A program to help myeloproliferative neoplasm patients improve their lifestyle

  This study is testing a 12-week program that helps people with myeloproliferative neoplasms improve their nutrition and physical activity to see if it can lead to healthier living.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT05842603

• Investigating cognitive impairment in young cancer patients during and after chemotherapy

  This study is testing how chemotherapy affects memory and attention in children and young adults with cancer to better understand their cognitive challenges during and after treatment.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05840575

• Targeted T-Cell and B-Cell Depletion for Hematologic Malignancies

  This study is testing a new way to prepare patients with blood cancers for stem cell transplants by removing certain immune cells to see if it helps them recover better and stay healthy longer.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05794880

• Impact of changing PICCline dressings on infection rates in leukemia patients

  This study is testing if changing the dressings on PICC lines more often can help reduce infection rates in leukemia patients receiving chemotherapy.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Montpellier · NCT05793801

• Impact of Leukemia and Lymphoma Society services on blood cancer patients

  This study is testing how the services provided by the Leukemia and Lymphoma Society can help people with blood cancers feel better and manage their care over six months.

  Recruiting University of Miami · Miami, Florida and 2 other locations · NCT05745285

• Molecular profiling for treating pediatric and young adult cancers

  This study is testing if using genetic information from tumors can help doctors find better treatments for kids and young adults with hard-to-treat cancers.

  Recruiting at 29 sites Gustave Roussy, Cancer Campus, Grand Paris · Amiens, France and 28 other locations · NCT05691608

• Improving quality of life for blood cancer patients receiving cellular therapy

  This study is testing a new palliative care program called PEACE to see if it can improve the quality of life for blood cancer patients getting cellular therapy.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05646576

• New treatment approach for pediatric patients with relapsed B-cell leukemia

  This study is testing a new combination treatment for kids with relapsed B-cell leukemia to see if it helps them get better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05645718

• CD30-targeted bispecific-antibody‑armed autologous T-cell therapy for relapsed CD30-positive blood cancers

  This treatment will try using a patient's own T cells armed with a CD30/CD3 bispecific antibody to treat adults with relapsed or refractory CD30-positive blood cancers.

  Recruiting Phase 1 Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05544968

• Combination treatment for newly diagnosed chronic lymphocytic leukemia

  This study is testing a new combination treatment for people with newly diagnosed chronic lymphocytic leukemia to see if it helps them achieve better health outcomes.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05536349

• Improving communication for Spanish-speaking families with cancer

  This study is trying to improve communication and support for Spanish-speaking families dealing with leukemia or non-Hodgkin lymphoma to help them feel more included and better understand their treatment.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT05425992

• A network for collaborative cancer research in Ontario

  This study is testing a new way to improve cancer treatment by using genetics and technology to help personalize care for people with different types of cancer.

  Recruiting at 2 sites University Health Network, Toronto · Kingston, Ontario and 2 other locations · NCT05403177

• Validation of a blood test for early cancer detection and monitoring

  This study is testing a blood test to see if it can help find different types of cancer early and monitor patients after treatment.

  Recruiting at 3 sites Adela, Inc · Duarte, California and 16 other locations · NCT05366881

• Effects of CAR T-cell therapy on thinking skills in young patients with blood cancer

  This study is trying to see how CAR T-cell therapy affects thinking skills in children and young adults with blood cancer over a year.

  Recruiting at 3 sites National Institutes of Health Clinical Center (CC) · Los Angeles, California and 2 other locations · NCT05237986

• Investigating early ageing in young cancer patients during treatment

  This study is trying to see how cancer treatment affects early aging and heart health in young adults aged 18-39 who are undergoing therapy for cancer.

  Recruiting University Medical Center Groningen · Groningen · NCT05062707

• Improving diagnosis of hematological diseases using advanced sequencing techniques

  This study is testing new genetic sequencing methods to help doctors better diagnose blood disorders in patients who currently have unclear or unusual symptoms.

  Recruiting Munich Leukemia Laboratory · Munich · NCT05046444

• Assessing cognitive effects of whole brain radiation therapy in blood cancer patients

  This study is testing how whole brain radiation therapy affects thinking and memory in blood cancer patients, while also looking at quality of life and brain changes over time.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05011045

• Genomic profiling of blood and bone marrow samples from children and young adults with blood cancers

  This study is testing how analyzing the genes in blood and bone marrow samples from kids and young adults with blood cancers can help doctors make better treatment decisions.

  Recruiting at 6 sites Dana-Farber Cancer Institute · Hartford, Connecticut and 7 other locations · NCT04968834

• Improving cognitive function in older adults after stem cell transplant

  This study is testing if a special exercise program can help older adults who had a stem cell transplant think better and improve their brain health.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT04898790

• Long-term study of blood diseases in patients in China

  This study is trying to gather detailed information from patients in China with blood diseases like leukemia and multiple myeloma to better understand how these conditions affect their lives and treatment options.

  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT04645199

• See if CXCR4 PET imaging helps diagnose and predict outcomes for lymphoproliferative diseases

  This early-phase imaging study tests whether 68Ga-Pentixafor PET/CT can help diagnose and predict prognosis for people with suspected or untreated lymphoproliferative diseases.

  Recruiting Early Phase 1 First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT04504526

• Improving leukemia diagnosis using artificial intelligence

  This study is testing whether an artificial intelligence system can improve the diagnosis of leukemia by comparing its accuracy and speed to traditional methods using a large set of blood samples.

  Recruiting Munich Leukemia Laboratory · Munich, Bavaria · NCT04466059

• Karonudib treatment for leukemia patients

  This study is testing a new treatment called Karonudib for people with advanced leukemia and multiple myeloma to see if it is safe and works better alone or with other standard treatments.

  Recruiting at 7 sites Phase 1 Thomas Helleday Foundation · Aarhus and 6 other locations · NCT04077307

• Using ponatinib to treat children with advanced leukemias, lymphomas, or solid tumors

  This study is testing if ponatinib can help children with hard-to-treat leukemias, lymphomas, or solid tumors feel better and have more treatment options.

  Recruiting at 22 sites Phase 1/2 Incyte Corporation · Ghent and 22 other locations · NCT03934372

• Combining venetoclax with Vyxeos for young patients with relapsed or refractory acute leukemia

  This study is testing a new treatment combining venetoclax and Vyxeos to see if it helps young patients with relapsed or hard-to-treat acute leukemia feel better.

  Recruiting Phase 1 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT03826992

• Developing a liquid biopsy protocol for cancer research at Princess Margaret

  This study is trying to create a simple way to collect blood samples from cancer patients to see if analyzing certain molecules in their blood can help doctors understand their cancer better and track how it changes over time.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03702309

• AI-based precision oncology clinical trial matching and registry

  This study is testing whether an AI tool can help match cancer patients with the right clinical trials based on their specific cancer details to see if it improves their chances of getting into trials and their overall outcomes.

  Recruiting at 68 sites Massive Bio, Inc. · Birmingham, Alabama and 67 other locations · NCT03452774

• HA-1 TCR T cell therapy for leukemia that returned or didn't respond after a donor stem cell transplant

  This Phase 1 study will test whether giving specially engineered donor T cells called HA-1 TCR T cells is safe and what dose works for people whose acute leukemia came back or didn't respond after a donor stem cell transplant.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03326921

• Genetic analysis of familial acute myeloid leukemia and myelodysplastic syndromes

  This study is trying to find out if there are specific genetic changes in families with a history of acute myeloid leukemia or myelodysplastic syndromes to help understand how these conditions can be passed down.

  Recruiting Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · Brescia · NCT03058588

• Registry for collecting data on adult Acute Lymphoblastic Leukemia patients

  This study is collecting information from adults with Acute Lymphoblastic Leukemia to see how well different treatments work and to improve care for future patients.

  Recruiting at 147 sites Goethe University · Graz and 146 other locations · NCT02872987

• Access to stem cell transplant for patients without matched donors

  This study is testing a new way to help patients without a matched donor get a stem cell transplant by using a special device to reduce complications and improve their chances of recovery.

  Recruiting Early Phase 1 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT02356653

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Combining cladribine, low-dose cytarabine, and decitabine for treating acute myeloid leukemia and high-risk myelodysplastic syndrome

  This study is testing a new combination of three drugs to see if it can help people with acute myeloid leukemia or high-risk myelodysplastic syndrome feel better and manage their disease.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT01515527

• Registry of older patients with cancer

  This study collects health information from older cancer patients to create a registry that helps improve care and research for seniors with cancer.

  Recruiting at 7 sites UNC Lineberger Comprehensive Cancer Center · Boone, North Carolina and 6 other locations · NCT01137825

• Collection of tissue, blood, and body fluid samples from patients with hematologic cancer

  This study is collecting tissue, blood, and body fluid samples from patients with blood cancers to help improve cancer research and patient care.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT01137643

• Long-term follow-up for childhood cancer survivors

  This study is trying to keep in touch with childhood cancer survivors to see how they are doing over time and understand the long-term effects of their treatments.

  Recruiting at 139 sites Children's Oncology Group · Birmingham, Alabama and 163 other locations · NCT00736749

• Understanding genetic causes of lymphoproliferative disorders in families

  This study is trying to find out how genetics play a role in lymphoproliferative disorders, like Hodgkin's disease and lymphoma, by looking at families with a history of these cancers.

  Recruiting at 6 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT00582621

NIH-funded research (newest 40 of 546)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating a specific type of leukemia in children caused by genetic changes.

  This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-9834651

• Caregiver-led mobile tool to support healthy habits for kids treated for ALL

  A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11630804

• Targeting the SCP4 pathway in acute myeloid leukemia (AML)

  Aims to uncover how the SCP4 signaling pathway drives AML and how it could be blocked to help patients.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11617813

• Understanding TCRs in Leukemia to Improve Immunotherapies

  A short, patient-friendly look at a project trying to map how immune cells recognize leukemia so future therapies can be better and safer for people with AML.

  NIH research University of Houston · Houston, United States · NIH-11616276

• Targeted therapy for AML using DHODH inhibitors to boost differentiation and immune response

  Aims to help adults with acute myeloid leukemia by using a special drug approach that makes cancer cells act more like normal blood cells and supports the immune system.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11611081

• Genomics of childhood ALL across global populations

  A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11608541

• Genomics of childhood ALL across diverse populations

  A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11608540

• Combinatorial targeting for high-risk B-cell ALL treatment

  A research effort at West Virginia University is exploring a combination therapy for adult B-cell acute lymphoblastic leukemia using targeted gene silencing and a small-molecule compound to improve treatment in patients.

  NIH research West Virginia University · Morgantown, United States · NIH-11579281

• Pediatric ALL drug testing in mice to guide clinical trials

  A program tests how new leukemia drugs work in children’s leukemia using mouse models to help pick the most promising treatments for early clinical trials.

  NIH research University of New South Wales · Sydney, Australia · NIH-11535766

• Understanding why Latino children have a higher risk of childhood ALL

  This project looks at why Latino children are more likely to develop acute lymphoblastic leukemia and whether genetic ancestry plays a role, with the goal of improving prevention and outcomes.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11520852

• Resources to understand environmental causes of childhood leukemia

  This project helps collect and share data to understand how environmental exposures may contribute to leukemia in young children, with special attention to LatinX communities.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11494225

• Targeting obesity to improve survival for children with ALL

  A new approach explores whether reducing obesity-related factors can make chemotherapy work better for kids with acute lymphoblastic leukemia.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11474567

• DNA methylation epimutations linked to AML development

  Researchers are studying how epigenetic changes in blood stem cells may drive acute myeloid leukemia in people with normal chromosomes.

  NIH research Washington University · Saint Louis, United States · NIH-11454858

• Interferon-γ plus donor immune cells to fight AML/MDS after partial donor transplant

  This project tests a therapy that adds a signaling protein, IFN-γ, with donor immune cells to help treat relapsed AML/MDS after a haploidentical stem cell transplant.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11453101

• Targeting the protein housekeeping system in adult leukemia

  Researchers are testing a new approach to treat acute myeloid leukemia by disrupting how AML cells manage their proteins, with the goal of helping patients live longer and healthier lives.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11452453

• Nup210’s role in leukemia and its potential as a target

  A doctor-scientist team is studying how a protein called Nup210 helps a type of blood cancer (AML) grow, with the goal of finding new ways to predict outcomes and treat the disease.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11451105

• TBL-1 and Wnt signaling in pediatric B- and T-cell ALL

  A project explores whether blocking TBL-1 can make pediatric B- and T-cell acute lymphoblastic leukemia easier to treat, especially after relapse.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11451103

• Understanding how epigenetic helper proteins drive AML and how to target them

  A scientist team is studying how accessory proteins in gene-regulating complexes affect acute myeloid leukemia and whether they can be targeted for safer, more precise therapies.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11448341

• Compartmentalized BCAA Metabolism in AML

  A study at St. Jude investigates how a specific amino acid pathway drives acute myeloid leukemia and whether targeting it could help diagnose or treat the disease.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11447829

• NSD2-NEO1 pathway and CNS spread of childhood ALL

  A pediatric leukemia study looks at how a gene mutation helps leukemia cells reach the brain, with the aim of finding targeted, less toxic treatments.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11447279

• Molecular categorization of pediatric T-ALL using big data and AI

  A pediatric leukemia grant that uses AI and big data from kids’ research to classify T-ALL subtypes and guide future treatments.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11442534

• Radiation and Heat and Childhood Leukemia in Kids

  A small, patient-friendly study will explore whether exposure to heat and sunlight in early childhood is linked to childhood leukemia and related genetic changes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11436968

• Pan-RAS inhibitor approach for JMML in children and young adults

  A study testing a Pan-RAS inhibitor to treat JMML, a pediatric leukemia, with potential implications for young patients and those with related RAS-driven diseases.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11433355

• Targeting inflammatory pathways in RAS-mutated AML stem cells

  Aimed at understanding and targeting inflammatory signals in leukemia stem cells that drive resistance to AML therapies, with the goal of improving responses for patients with RAS-mutated AML.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11432603

• Metformin to help prevent cognitive side effects of chemotherapy in kids with ALL

  A study tests whether metformin given during leukemia treatment can protect brain development and thinking skills in children with acute lymphoblastic leukemia.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11429689

• New RPS23 inhibitors to help treat AML

  A new therapy approach targets leukemia cells by activating a stress response pathway that can push cancer cells toward death, especially when used with existing treatment venetoclax.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11428745

• Targeting FLVCR1-enabled choline use in a aggressive AML subtype

  A new approach aims to block how a specific leukemia subtype (CG-AML) takes up choline to feed its growth, potentially slowing or stopping the disease.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11427960

• Understanding how ENL and AF9 drive leukemia to guide better therapies

  This grant studies how specific cancer proteins (ENL and AF9) contribute to AML and ALL to help develop targeted leukemia treatments.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11426863

• Advancing CD70-targeted CAR-NK Therapy for AML

  A patient-focused look at a new cell therapy that uses engineered NK cells to target AML by hitting CD70, aiming to reduce relapse with potentially fewer blood cell problems.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11425793

• New drug target pathway to fight acute myeloid leukemia (AML) by disrupting selenium use

  A new grant explores how AML cells depend on selenium metabolism and how blocking certain regulators can trigger cancer cell death, with potential benefits for adults with AML.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11424976

• Specialized Program of Research Excellence in Leukemia

  A dedicated program at Washington University aims to translate leukemia research into new biomarkers and treatments that could help people with leukemias and related disorders.

  NIH research Washington University · Saint Louis, United States · NIH-11423670

• Disparities in childhood ALL: how patients' reports, biology, and neighborhoods shape outcomes

  This project explores why Latino children with acute lymphoblastic leukemia have worse outcomes by looking at patient-reported experiences, epigenetic patterns, and neighborhood factors.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420849

• Pharmacogenomics to tailor ALL treatment for Latino kids

  A research program will study how genetic differences affect how Latino children with acute lymphoblastic leukemia respond to treatment, with the aim of guiding safer, more effective care.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420847

• Understanding why some children with ALL have more side effects from methotrexate and how it affects their health

  This project looks at why Latino children with acute lymphoblastic leukemia experience more neurotoxicity from methotrexate and how that affects their short- and long-term outcomes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420843

• Reducing leukemia disparities in Latino children and teens

  A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420825

• Transgenic T Cell Therapy for AML in Adults

  A patient-centered approach uses engineered autologous T cells to target AML in adults who may not be eligible for transplant.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11420378

• Adult Leukemia Research Center: Understanding and Preventing Immune Toxicity in Adoptive Cell Therapies

  Researchers at Fred Hutchinson Cancer Center are studying how the immune system reacts to advanced cell therapies for AML and multiple myeloma to prevent dangerous side effects and improve treatment success for adults over 60.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11420371

• Role of VISTA in AML immune evasion

  A companying therapy goal is to block a specific immune brake (VISTA) to help the immune system fight acute myeloid leukemia.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11418478

• Chronic myeloid leukemia: how T cells and leukemia stem cells interact during treatment

  This NIH grant explores how immune cells and stubborn leukemia stem cells interact during therapy to better predict if patients can stay off treatment.

  NIH research Northwestern University · Chicago, United States · NIH-11418370

• Enhancing treatments for myeloid leukemia with Down syndrome

  This grant explores how bone marrow support cells affect treatment response in children with Down syndrome–related leukemia and aims to improve chemotherapy effectiveness.

  NIH research Wayne State University · Detroit, United States · NIH-11417888

Related topics

Quick answers

How many Leukemia clinical trials are recruiting right now?

96, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (59 trials), China (10 trials), Australia (6 trials), France (6 trials), Italy (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 14, Phase 2: 11, Phase 1/2: 7, Phase 2/3: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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