Improving outcomes for stem cell transplant patients using an intervention website
Mosaic: RCT of a Digital Health Intervention for English- and Spanish-speaking Stem Cell Transplant Recipients
This study is testing if a special website can help adults with blood cancer feel better and improve their quality of life after a stem cell transplant compared to a regular educational website.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 356 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Northwestern University Academic / other |
| Locations | 3 sites (Washington D.C., District of Columbia and 2 other locations) |
| Trial ID | NCT06960993 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to determine if an intervention website called Mosaic can enhance patient-reported outcomes for adults with blood cancer undergoing stem cell transplants, compared to a standard educational website. Patients will be recruited before their scheduled transplant and randomly assigned to use either the intervention or control website throughout the study. They will complete assessments at baseline and at 2, 4, 6, and 8 months post-transplant to evaluate psychological distress, physical symptoms, and overall quality of life. The study seeks to understand if improvements in these areas are linked to factors like perceived preparedness and self-efficacy.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 or older diagnosed with hematologic cancers who are scheduled for stem cell transplants and are proficient in English or Spanish.
Not a fit: Patients currently involved in other behavioral interventions targeting distress or those with severe cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved psychological and physical well-being for patients undergoing stem cell transplants.
How similar studies have performed: Other studies have shown promise in using digital interventions to improve patient outcomes, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with a hematologic cancer according to medical records * Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of our study sites * Aged 18 or older (no upper limit) * English or Spanish Proficient * Interested in using a website to learn about stem cell transplant * Ability to understand and willingness to sign an informed consent document and comply with all study procedures Exclusion Criteria: * Currently participating in a behavioral intervention targeting distress, health-related quality of life, or symptoms * Undergoing the first in a planned tandem stem cell transplant * Unable to provide meaningful consent (severe cognitive impairment or language difficulties)
Where this trial is running
Washington D.C., District of Columbia and 2 other locations
- Georgetown University School of Medicine — Washington D.C., District of Columbia, United States (Recruiting)
- Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States (Recruiting)
- Hackensack Meridian Health — Nutley, New Jersey, United States (Recruiting)
Study contacts
- Study coordinator: Christine Rini, PhD
- Email: christine.rini@northwestern.edu
- Phone: 312-503-7715
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.