Condition

Acute Lymphoblastic Leukemia clinical trials and research

• 113Clinical trials
• 82NIH research projects
• 46Countries

Newest Acute Lymphoblastic Leukemia clinical trials

All recruiting trials (113)

• Low-dose Liposomal Amphotericin B for preventing fungal infections in adults with blood cancers and prolonged neutropenia

  This study tests whether giving a daily 50 mg dose of liposomal amphotericin B can help prevent invasive fungal infections in adults with blood cancers who have prolonged low white blood cell counts.

  Recruiting Haikou Affiliated Hospital of Central South University Xiangya School of Medicine · Hainan, Hainan · NCT07763054

• Observatory of adults with Ph+ ALL receiving BCR-ABL1 inhibitors with chemotherapy, steroids, or monoclonal antibodies

  This study follows adults with Philadelphia-positive acute lymphoblastic leukemia who are being treated with a combination of BCR-ABL1 inhibitors and other therapies to see how they fare in real-world practice.

  Recruiting at 7 sites Versailles Hospital · Amiens and 22 other locations · NCT07684131

• Strength Training for Kids with Acute Lymphoblastic Leukemia and Lymphoblastic L lymphoma

  Researchers are testing a structured strength-training program for children and teens recently diagnosed with ALL or lymphoblastic lymphoma to see if it helps with weight gain and physical function during treatment.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07634653

• FXS0683 in relapsed or refractory blood cancers

  This first‑in‑human study tests FXS0683 in adults with relapsed or refractory B‑cell lymphoma, AML, MDS, or ALL to see if it is safe, how the drug behaves in the body, and whether it shows any antitumor activity.

  Recruiting Phase 1 Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. · Tianjin, Tianjin Municipality · NCT07616089

• CD19-targeted CAR-T cells that make p40 for relapsed or refractory CD19-positive blood cancers

  This trial will try a patient's own CD19-directed CAR-T cells engineered to produce p40 to see if they work better and last longer in adults with relapsed or refractory CD19-positive blood cancers.

  Recruiting Phase 1/2 Shenzhen University General Hospital · Shenzhen, Other (Non U.s.) · NCT07584889

• TSLPR-CART therapy for CRLF2-R/TSLPR–expressing B-ALL in adults

  This study tests a CAR T-cell treatment called TSLPR-CART in adults whose B-ALL cells overexpress TSLPR and have not responded to standard therapy.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07572136

• Cord blood transplant for children and young adults with blood cancers.

  This study will test whether a cord blood transplant given as a first or second transplant can help children and young adults with leukemia, myelodysplasia, or lymphoma who lack a matched donor.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT07566377

• Optimizing Erwinase dosing to reach safe trough levels in children and young adults with ALL

  This project tries to create a dosing model for Erwinase to help children and young adults with ALL reach safe trough drug levels while reducing the risk of high exposures like hyperammonemia.

  Recruiting Aarhus University Hospital · Aarhus · NCT07499349

• At-home cognitive training and mindfulness for children after CAR-T, transplant, or chemotherapy

  This program tests whether remote digital cognitive exercises combined with adapted mindfulness can help thinking, behavior, and brain function in children and teens treated for acute lymphoblastic leukemia after CAR‑T, chemotherapy, or transplant.

  Recruiting Hospital Universitario La Paz · Madrid, Madrid · NCT07479927

• ABL‑ or JAK‑targeted drugs with chemotherapy and venetoclax for Ph‑like ALL

  This protocol tests whether adding an ABL‑targeted or JAK‑targeted drug plus venetoclax to standard chemotherapy helps people aged 14–60 with newly diagnosed Ph‑like acute lymphoblastic leukemia get deeper remissions.

  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT07454226

• Obecabtagene autoleucel as consolidation for B‑cell acute lymphoblastic leukemia in MRD‑negative remission

  This study will test whether a single infusion of obecabtagene autoleucel can help adults with CD19+ B‑cell acute lymphoblastic leukemia who are in their first MRD‑negative complete remission stay in remission longer.

  Recruiting at 9 sites Phase 2 Memorial Sloan Kettering Cancer Center · Duarte, California and 8 other locations · NCT07400029

• Asciminib in children and young adults with relapsed or refractory Ph+ or ABL-class Ph-like ALL

  This study tests asciminib in kids and young adults with relapsed or refractory Philadelphia-positive or ABL-class Ph-like ALL to see if it is safe and helps treat the leukemia.

  Recruiting at 4 sites Phase 1/2 Novartis · Sydney, New South Wales and 3 other locations · NCT07387926

• Point-of-care MB-CART19.1 CAR-T therapy for relapsed or refractory B‑ALL

  This will test whether autologous, point-of-care manufactured CD19-directed CAR-T cells (MB-CART19.1) can treat children and adults with relapsed or refractory B‑cell acute lymphoblastic leukemia.

  Recruiting King Hussein Cancer Center · Amman · NCT07371403

• Revumenib with Mezigdomide for relapsed or refractory acute leukemia

  This trial will test whether combining revumenib and mezigdomide is safe for people aged 12 and older with relapsed or refractory acute leukemia that has KMT2A, NUP98, or NPM1 genetic changes.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Duarte, California and 9 other locations · NCT07356154

• Using CD22 CAR T-cells to extend remission after commercial CD19 CAR T-cell therapy in children, adolescents, and adults with relapsed/refractory B‑ALL

  This will try giving CD22-targeted CAR T-cells to people aged 3–65 who are in remission after CD19 CAR T-cell therapy to see if it helps keep their B-ALL from coming back longer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07328503

• Exercise and activity tracking during early treatment for children with ALL to prevent muscle loss and frailty

  This pilot test tries a home-based physical activity and strengthening program with a Fitbit for children aged 5–17 who show early muscle weakness after starting treatment for acute lymphoblastic leukaemia to see if it prevents muscle loss and improves strength compared with usual care.

  Recruiting Murdoch Childrens Research Institute · Melbourne, Victoria · NCT07325305

• ChromoSeq testing in kids with ALL to help classify at diagnosis

  This study tests how well ChromoSeq® genetic sequencing can classify pediatric and young adult patients with suspected ALL using samples collected at initial workup.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07313592

• LV009 injection for relapsed or refractory CD19-positive blood and lymph cancers

  This will test whether LV009 injections are safe for adults with relapsed or refractory CD19-positive non-Hodgkin lymphoma or acute lymphoblastic leukemia.

  Recruiting Phase 1 PersonGen BioTherapeutics (Suzhou) Co., Ltd. · Suzhou, Jiangsu · NCT07284927

• Child and Young Adult (CAYA) Cancer Outcomes Review

  This project looks at past treatment results to see what affects outcomes for children and young adults (ages 0–21) with leukemia and other cancers treated at participating centers in low- and middle-income countries.

  Recruiting at 5 sites Resonance, Inc. · Yerevan and 6 other locations · NCT07246213

• Tirzepatide plus guided resistance exercise for weight loss in adult survivors of childhood ALL

  This 28-week program will try once-weekly tirzepatide together with remote, supervised resistance training to help adult survivors of childhood ALL who have obesity or overweight with a related health condition lose weight.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07228741

• ALL Backbone in AYAs

  Aims to see if a chemotherapy regimen can safely and effectively treat newly diagnosed Philadelphia chromosome-negative ALL in adolescents and young adults.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07227584

• Mandala coloring to reduce anxiety and fear in children with leukemia before intrathecal chemotherapy

  This will try mandala coloring with children aged 4–12 who have leukemia to see if it lowers their anxiety and fear before intrathecal chemotherapy.

  Recruiting Ege University · Izmir · NCT07203742

• Targeted drug plus chemotherapy for adult T-cell acute lymphoblastic leukemia

  This trial tests whether adding a targeted drug to standard chemotherapy helps adults with T-cell acute lymphoblastic leukemia have better responses than chemotherapy alone.

  Recruiting Phase 3 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07203352

• CD19 CAR-T consolidation for adolescents and adults with B-ALL who cannot have a transplant

  This treatment tries CD19 CAR-T cell infusions to see if they help adolescents and adults with B-ALL who are unable to get an allogeneic stem cell transplant stay in remission.

  Recruiting at 2 sites Phase 1/2 Zhujiang Hospital · Guangzhou, Guangdong and 1 other locations · NCT07072494

• FIT-CD19 CAR-T (ARM011) therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukemia.

  This will test whether a non-viral CD19 CAR-T therapy (ARM011), given after short lymphodepleting chemotherapy, is safe and helps adults with relapsed or refractory B-cell acute lymphoblastic leukemia.

  Recruiting Phase 1 TriArm Therapeutics (Taiwan) Limited · Taipei · NCT07066397

• CMV Triplex vaccine to boost immunity and prevent CMV after haploidentical stem cell transplant

  This trial tests whether giving a CMV-MVA Triplex vaccine to donors and/or recipients, with or without the antiviral letermovir, can boost CMV immunity and prevent CMV viremia in people having haploidentical stem cell transplants.

  Recruiting at 3 sites Phase 1 City of Hope Medical Center · Duarte, California and 2 other locations · NCT07020533

• Ciprofloxacin versus ceftazidime for high-risk neutropenic fever in children with blood cancers

  We will test whether ceftazidime or ciprofloxacin works better as the first antibiotic for children (0–18) with blood cancers who develop high-risk fever from low neutrophil counts.

  Recruiting Phase 4 Gadjah Mada University · Sleman, DI Yogyakarta · NCT07016165

• Full-course immunotherapy for B‑cell acute lymphoblastic leukemia patients who are unfit for or decline chemotherapy

  This study will try a full course of sequential immunotherapy with blinatumomab followed by inotuzumab ozogamicin for people with B‑cell ALL who are older, unfit for, have relapsed/refractory disease, or who decline intensive chemotherapy.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06985485

• Hepatoprotective program for children with acute lymphoblastic leukemia

  This study tests if changes in diet and omega-3 supplements can help protect the livers of children with acute lymphoblastic leukemia during their chemotherapy treatment.

  Recruiting at 2 sites Phase 4 Ain Shams University · Cairo and 1 other locations · NCT06918054

• Short-course blinatumomab treatment for B-ALL patients with measurable residual disease

  This study tests whether a short treatment with blinatumomab can help people with B-cell acute lymphoblastic leukemia who still have some cancer cells left after their initial treatment, before they get a stem cell transplant.

  Recruiting Phase 2 Hospital Universitario Dr. Jose E. Gonzalez · Monterrey, Nuevo León · NCT06886074

• Comparing new immunotherapies and donor stem cell transplant as first treatment for adults with acute lymphoblastic leukemia

  This study will test whether adding newer immunotherapy drugs and/or using donor stem cell transplant up front improves outcomes for adults (18–65) newly diagnosed with acute lymphoblastic leukemia.

  Recruiting Phase 2/3 Assistance Publique - Hôpitaux de Paris · Paris · NCT06860269

• New treatment approach for children newly diagnosed with T‑cell acute lymphoblastic leukemia using dasatinib, venetoclax, and homoharringtonine

  This study will try adding dasatinib, venetoclax, and homoharringtonine to standard chemotherapy for children and adolescents newly diagnosed with T‑cell acute lymphoblastic leukemia to see if it increases deep (MRD‑negative) remissions and lowers relapse.

  Recruiting Phase 2/3 Institute of Hematology & Blood Diseases Hospital, China · Hefei, Anhui and 26 other locations · NCT06855810

• CAR T cell therapy for young patients with CD19-positive leukemia

  This study is testing a new treatment combining CAR T cell therapy and chemotherapy to see if it helps young patients with hard-to-treat leukemia.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06847269

• Efficacy and safety of TmBU conditioning for high-risk leukemia patients

  This study is testing a new treatment approach for high-risk leukemia patients to see if it helps them stay cancer-free after a stem cell transplant better than the current method.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06816134

• Vedolizumab with post-transplant cyclophosphamide and short-course tacrolimus to prevent graft-versus-host disease after reduced-intensity allogeneic stem cell transplant

  This trial tests whether adding vedolizumab to post-transplant cyclophosphamide and a short course of tacrolimus can prevent graft-versus-host disease in adults getting reduced-intensity allogeneic stem cell transplants for leukemias or related blood disorders.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06815003

• CAR T cell therapy for children with acute lymphoblastic leukemia

  This study is testing a new type of CAR T cell therapy to see if it can safely help children and young adults with hard-to-treat leukemia.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06777979

• Preventing GVHD in children and young adults with blood cancers

  This study is testing a new treatment plan to see if it can help prevent graft-versus-host disease in children and young adults with blood cancers after they receive a transplant.

  Recruiting Phase 2/3 Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Moscow · NCT06756152

• CAR-T cell therapy for children with MRD-positive B-ALL

  This study is testing a new CAR-T cell therapy for children with a type of leukemia who still have leftover cancer cells after their first treatment, to see if it can help them get better.

  Recruiting Phase 1 Guangzhou Women and Children's Medical Center · Guangzhou, Guangdong · NCT06752785

• Using CMV-specific CAR T cells and a vaccine to treat high-risk acute lymphoblastic leukemia after stem cell transplant

  This study is testing a new treatment using special immune cells and a vaccine to see if it can help people with high-risk acute lymphoblastic leukemia after they have a stem cell transplant.

  Recruiting Early Phase 1 City of Hope Medical Center · Duarte, California · NCT06735690

• Treatment for MRD-Positive B-ALL Patients Using CAR-T Therapy

  This study is testing a new CAR-T therapy to see if it can help adults with a specific type of leukemia who still have some cancer cells left after their first treatment.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06718244

• Treatment of relapsed B-cell acute lymphoblastic leukemia with PRG-2302

  This study is testing a new treatment called PRG-2302 to see if it can help adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia.

  Recruiting Early Phase 1 The First People's Hospital of Jingzhou · Jinzhou, Hubei · NCT06659653

• Using revumenib to treat acute leukemia after stem cell transplant

  This study is testing a new drug called revumenib to see if it can help people with acute leukemia feel better after they’ve had a stem cell transplant.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06575296

• New treatment for children and young adults with newly diagnosed B-cell leukemia and lymphoma

  This study is testing if two new treatments can help children and young adults with newly diagnosed B-cell leukemia and lymphoma achieve better remission results than older therapies.

  Recruiting at 3 sites Phase 2 St. Jude Children's Research Hospital · Charlotte, North Carolina and 2 other locations · NCT06533748

• Vitamin A and D supplementation for patients undergoing allogeneic hematopoietic transplantation

  This study is testing if giving high doses of vitamins A and D before a stem cell transplant can help patients with certain blood cancers have fewer complications like infections and graft-versus-host disease.

  Recruiting Phase 2 St. Petersburg State Pavlov Medical University · Saint Petersburg · NCT06508099

• Comparing two conditioning regimens for haploidentical stem cell transplantation

  This study is testing two different treatment plans for patients getting stem cell transplants from partially matched donors to see which one works better in preventing complications like graft failure and relapse.

  Recruiting Phase 2 St. Petersburg State Pavlov Medical University · Saint Petersburg · NCT06477549

• Detecting leukemia stem cells in blood and bone marrow to predict relapse in acute leukemia

  This study is testing if finding leukemia stem cells in the blood and bone marrow can help doctors predict relapses in children under 18 with acute leukemia.

  Recruiting at 2 sites Peking University People's Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06452732

• Text messages to help sticking with oral chemotherapy in ALL and T-cell lymphoma

  Researchers are testing whether sending high‑frequency text reminders helps teens and adults on oral mercaptopurine and methotrexate stick with their treatment.

  Recruiting University of Chicago · Chicago, Illinois · NCT06446661

• Using CD22 CAR T Cells after CD19 CAR T Cells for B Cell Leukemia

  This study is testing if giving CD22 CAR T-cell therapy to children and young adults with tough-to-treat B-cell leukemia after they’ve had another CAR T-cell treatment can be safe and effective.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT06408194

• Understanding how dexamethasone affects children with leukemia and their bone health

  This study looks at how the medication dexamethasone affects bone health in children with leukemia by checking their bone density and medication levels over time.

  Recruiting at 4 sites University of Aarhus · Aalborg, Aalborg and 3 other locations · NCT06367725

• Treatment for Chronic Lymphocytic Leukemia using modified T cells

  This study is testing a new treatment using modified T cells to see if it can help people with chronic lymphocytic leukemia that hasn't responded to other therapies.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06364423

• Early heart function check after CAR-T treatment

  We will test whether people treated with CAR‑T cells for blood cancers have early changes in heart function by doing an ultrasound and blood tests 3–5 days after infusion.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06350994

• Intervention to improve medication adherence in children with leukemia

  This study is testing a new support program to help families of children with leukemia stick to their medication routine and see if it works better than regular care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06323044

• Combining blinatumomab and asciminib for treating a type of leukemia

  This study is testing if combining two drugs, blinatumomab and asciminib, can help people with a specific type of leukemia feel better and improve their chances of recovery.

  Recruiting at 2 sites Phase 1/2 M.D. Anderson Cancer Center · The Bronx, New York and 1 other locations · NCT06308588

• Using post-transplant cyclophosphamide and ATG for blood cancer transplants

  This study is testing whether using post-transplant cyclophosphamide and ATG can help prevent graft-versus-host disease in patients with blood cancers who are getting stem cell transplants.

  Recruiting Phase 1/2 Instituto Nacional de Cancer, Brazil · Rio de Janeiro, Rio de Janeiro · NCT06299462

• Comparing Raman Spectroscopy to Flow Cytometry for Detecting Leukemia

  This study is testing if a new light-based method called Raman spectroscopy can better detect leftover leukemia cells in patients with acute lymphoblastic leukemia compared to the usual flow cytometry method.

  Recruiting Hospital Regional de Alta Especialidad del Bajio · León, Guanajuato · NCT06291428

• Identifying treatment needs for newly diagnosed acute leukemia and lymphoma

  This study is testing a new 7-day chemotherapy treatment for people newly diagnosed with acute lymphoblastic leukemia, lymphoblastic lymphoma, or mixed phenotype acute leukemia to see how well it works and to better understand their risk of recurrence.

  Recruiting at 5 sites Phase 4 St. Jude Children's Research Hospital · San Diego, California and 4 other locations · NCT06289673

• Using a new antibody treatment with chemotherapy and radiation for high-risk blood cancers before stem cell transplant

  This study is testing a new antibody treatment combined with chemotherapy and radiation to see if it can help people with high-risk blood cancers before they receive a stem cell transplant.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06287944

• Using CAR-T cells to treat relapsed CD19+ cancers

  This study is testing if a new type of immune cell treatment can help people with certain cancers that have come back or didn't respond to other treatments.

  Recruiting Phase 1 University of Utah · Salt Lake City, Utah · NCT06227026

• Treatment for newly diagnosed Philadelphia Chromosome-positive acute lymphoblastic leukemia

  This study is testing a new combination treatment for people with newly diagnosed Philadelphia Chromosome-positive acute lymphoblastic leukemia to see if it can help them achieve complete remission and improve their chances of survival.

  Recruiting Phase 2 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06220487

• Treatment for B-Cell Acute Lymphoblastic Leukemia with KTE-X19

  This study is testing if a new CAR T-cell therapy called KTE-X19 can help adults with B-Cell Acute Lymphoblastic Leukemia who are in remission but still have some leftover cancer cells.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT06144606

• Using ruxolitinib, tacrolimus, and methotrexate to prevent graft versus host disease in young patients after bone marrow transplant

  This study is testing if a combination of three medications can help prevent graft versus host disease in young patients after they receive a bone marrow transplant for certain types of leukemia or blood disorders.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06128070

• Vaccination to prevent CMV infection in stem cell transplant patients

  This study is testing a new vaccine to see if it can help prevent CMV infections in patients receiving stem cell transplants from related donors.

  Recruiting at 3 sites Phase 2 City of Hope Medical Center · Duarte, California and 2 other locations · NCT06059391

• Using cord blood transplant and chemotherapy to treat high-risk blood cancers

  This study is testing if combining umbilical cord blood transplants with certain chemotherapy treatments can help people with high-risk blood cancers do better and have fewer side effects.

  Recruiting Phase 2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT06013423

• A virtual dietary education program to prevent weight gain in children with leukemia

  This study is testing a virtual nutrition program to see if it can help children with leukemia avoid gaining weight while they are receiving treatment.

  Recruiting Columbia University · New York, New York · NCT05963971

• International Childhood Leukemia Microbiome and Metabolome Cohort

  This study is trying to see how nutrition affects treatment and recovery in children aged 3 to 18 who have just been diagnosed with acute lymphoblastic leukemia.

  Recruiting at 7 sites Columbia University · New York, New York and 7 other locations · NCT05929976

• Combining stem cell collection with CAR T-cell therapy for blood cancers

  This study is testing if collecting stem cells from patients with blood cancers can safely be combined with CAR T-cell therapy to improve treatment outcomes.

  Recruiting Phase 1 Cedars-Sinai Medical Center · Los Angeles, California · NCT05887167

• Optimizing mercaptopurine treatment for children with leukemia

  This study is trying to find the best way to use mercaptopurine to help children with leukemia stay healthy and avoid side effects during their treatment.

  Recruiting at 4 sites IRCCS Burlo Garofolo · Monza, Monza Brianza and 3 other locations · NCT05811845

• Depleting specific immune cells in stem cell transplants for blood cancers

  This study is testing if removing certain immune cells during stem cell transplants can help children and young adults with blood cancers have better outcomes and fewer complications.

  Recruiting Phase 2 University of Florida · Gainesville, Florida · NCT05800210

• Dasatinib and venetoclax with dexamethasone, cyclophosphamide, and cytarabine for children and young adults with relapsed or refractory ALL/LBL with MAPK/SRC changes

  This treatment tests whether adding dasatinib and venetoclax to dexamethasone, cyclophosphamide, and cytarabine helps children and young people (up to 21) whose relapsed or refractory acute lymphoblastic leukemia or lymphoblastic lymphoma have specific MAPK/SRC pathway changes.

  Recruiting at 2 sites Phase 1/2 Princess Maxima Center for Pediatric Oncology · Vienna and 32 other locations · NCT05751044

• Evaluating Inotuzumab Ozogamicin for Children with Relapsed Acute Lymphoblastic Leukemia

  This study is testing if a new drug called Inotuzumab Ozogamicin can help children with relapsed acute lymphoblastic leukemia do better than the usual treatment.

  Recruiting at 65 sites Phase 2 Pfizer · Vienna and 64 other locations · NCT05748171

• T cell receptor depletion for blood cancer treatment

  This study is testing a new way to treat blood cancers by using a special treatment before a stem cell transplant to see if it helps both kids and adults do better after the procedure.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05735717

• Treatment for relapsed or refractory B-cell acute lymphoblastic leukemia

  This study is testing a new combination treatment for people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia to see if it can help them respond better than current options.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT05657652

• Evaluating blood tests to monitor recovery after CAR T-cell therapy in young patients with leukemia

  This study is testing new blood tests to help doctors keep an eye on young patients with leukemia after their CAR T-cell therapy to see who might need extra treatment and who can stay healthy without it.

  Recruiting at 8 sites National Institutes of Health Clinical Center (CC) · Los Angeles, California and 7 other locations · NCT05621291

• CAR-T cell therapy for relapsed or treatment-resistant blood cancers

  This trial will test whether an autologous CAR-T cell infusion is safe and tolerable for people ages 14–75 with relapsed or refractory leukemia, lymphoma, or multiple myeloma whose tumors express CD19, CD20, or BCMA.

  Recruiting Hebei Senlang Biotechnology Inc., Ltd. · Taiyuan, Shanxi · NCT05618041

• CalPeg treatment for newly diagnosed acute lymphoblastic leukemia

  This study is testing if adding a new treatment called calaspargase pegol to standard chemotherapy helps people with newly diagnosed acute lymphoblastic leukemia feel better and have fewer side effects.

  Recruiting Phase 1 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT05581030

• New treatment for relapsed or refractory precursor B-cell Acute Lymphoblastic Leukemia

  This study is testing a new treatment called MK-1045 for children and adults with relapsed or hard-to-treat precursor B-cell Acute Lymphoblastic Leukemia to see how safe and effective it is.

  Recruiting at 8 sites Phase 1/2 MSD R&D (China) Co., Ltd. · Chongqing, Chongqing Municipality and 10 other locations · NCT05579132

• Evaluating the effectiveness and safety of tisagenlecleucel therapy in Brazilian patients with B-cell malignancies

  This study is testing how well and safely a treatment called tisagenlecleucel works for Brazilian patients with certain types of blood cancers, including lymphoma and leukemia, over a long follow-up period.

  Recruiting at 7 sites Novartis · Minas Gerais, Belo Horizonte and 6 other locations · NCT05541341

• CAR T therapy for adults with B-ALL in first remission and MRD positivity

  This study is testing a new CAR T cell therapy for adults with B-cell acute lymphoblastic leukemia who are in their first remission but still have some cancer cells left, to see if it is safe and effective.

  Recruiting Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT05535855

• Preventing neurotoxicity in leukemia treatment with intrathecal chemotherapy

  This study is testing if giving a specific chemotherapy directly into the spine can help protect the brain from side effects while treating adults with Acute Lymphoblastic Leukemia.

  Recruiting Phase 2 Northside Hospital, Inc. · Atlanta, Georgia · NCT05519579

• New CAR T-cell therapy for children and young adults with certain blood cancers

  This study is testing a new CAR T-cell therapy that uses modified cells from children's and young adults' own blood to see if it can help treat certain tough-to-treat blood cancers.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05442515

• Investigating nutrition's impact on childhood cancer outcomes

  This study is trying to see how nutrition affects the health and recovery of children with leukemia and brain tumors in Southern Europe.

  Recruiting Columbia University · New York, New York · NCT05375617

• Treatment of relapsed or refractory B-ALL in children and adolescents using pCAR-19B

  This study is testing a new CAR T-cell therapy called pCAR-19B to see if it can help children and teens with hard-to-treat B-cell leukemia feel better.

  Recruiting at 16 sites Phase 2 Chongqing Precision Biotech Co., Ltd · Beijing, Beijing Municipality and 15 other locations · NCT05334823

• Collecting blood samples to evaluate tests for early cancer detection

  This study is collecting blood and tissue samples from people with and without cancer to see if new tests can help detect cancer earlier.

  Recruiting at 619 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 750 other locations · NCT05334069

• Treatment for infants with specific types of leukemia

  This study is testing a new treatment using blinatumomab for infants with specific types of leukemia to see if it can help them respond better to therapy.

  Recruiting at 101 sites Phase 3 Princess Maxima Center for Pediatric Oncology · Buenos Aires and 123 other locations · NCT05327894

• Precision medicine approach for leukemia treatment

  This study is trying to find better ways to treat people with newly diagnosed leukemia by collecting data to create personalized treatment plans.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Bobigny and 2 other locations · NCT05326919

• Reduced-intensity conditioning to lower treatment-related mortality in stem cell transplant patients

  This study is testing a new way to prepare patients for a stem cell transplant to see if it can lower the risk of serious treatment-related complications.

  Recruiting Phase 2 Thomas Jefferson University · Philadephia, Pennsylvania · NCT05031897

• Exercise, lung, and heart fitness in young survivors of heart transplant, childhood leukemia, and premature lung disease

  This project tests non-invasive exercise and breathing tests to see how well 8–25-year-olds who survived childhood leukemia, were born with chronic lung disease of prematurity, or had a heart transplant tolerate and perform during physical activity.

  Recruiting Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05025774

• Investigating genetic changes in cord blood from childhood leukemia patients

  This study is trying to understand the genetic changes in cord blood from children with leukemia to see if it can help find early signs of the disease before it develops.

  Recruiting Children's Oncology Group · Minneapolis, Minnesota · NCT05014165

• Comparing T Cell Depletion Methods for Blood Cancer Treatment

  This study is testing different ways to prevent complications after a stem cell transplant for blood cancer to see which method helps patients stay healthy and cancer-free longer.

  Recruiting at 17 sites Phase 2 University of Birmingham · Cardiff, Wales and 16 other locations · NCT04888741

• Testing MRX-2843 in adolescents and adults with certain types of leukemia

  This study is testing a new drug called MRX-2843 to see if it is safe and effective for adolescents and adults with certain types of leukemia that have not responded to other treatments.

  Recruiting at 3 sites Phase 1 Meryx, Inc. · Atlanta, Georgia and 2 other locations · NCT04872478

• Chemotherapy-free treatment for Ph+ Acute Lymphoblastic Leukemia using Inotuzumab Ozogamicin

  This study is testing if adding a new drug called inotuzumab ozogamicin to standard treatment can help adults with newly diagnosed Ph+ acute lymphoblastic leukemia get better faster and more completely.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT04747912

• Screening for pediatric leukemia in children with relapsed or difficult-to-treat cases

  This study is testing how to better screen children and young adults with tough cases of leukemia to see if they qualify for new treatment options.

  Recruiting at 174 sites Phase 1/2 PedAL BCU, LLC · Birmingham, Alabama and 183 other locations · NCT04726241

• Injection of CTA101 UCAR-T cells for patients with relapsed or refractory CD19+ B-line blood cancers

  This study is testing if injections of a new type of immune cell therapy can help patients with certain types of blood cancers that have come back or didn’t respond to other treatments.

  Recruiting Early Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT04227015

• Donor stem cell transplant with chemotherapy and radiation for blood cancers

  This study is testing if a donor stem cell transplant combined with different doses of chemotherapy and radiation can help people with blood cancers recover better.

  Recruiting Phase 2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT04195633

• Treatment for adults with a specific type of leukemia

  This study is testing a new treatment plan for adults with a specific type of leukemia to see if it helps them stay healthy after their initial therapy.

  Recruiting at 23 sites PETHEMA Foundation · Badalona, Barcelona and 107 other locations · NCT04179929

• Revumenib treatment for relapsed/refractory leukemias with specific genetic mutations

  This study is testing a new drug called revumenib to see if it can help people with certain types of relapsed or hard-to-treat leukemias that have specific genetic changes.

  Recruiting at 38 sites Phase 1/2 Syndax Pharmaceuticals · Duarte, California and 56 other locations · NCT04065399

• Strategies to reduce graft versus host disease in blood stem cell transplant patients with acute leukemia or MDS

  This study is testing two different treatment plans to see which one better helps prevent graft versus host disease in patients with acute leukemia or myelodysplastic syndrome after they receive a blood stem cell transplant.

  Recruiting at 3 sites Phase 2 Fred Hutchinson Cancer Center · Tampa, Florida and 2 other locations · NCT03970096

• Using ponatinib to treat children with advanced leukemias, lymphomas, or solid tumors

  This study is testing if ponatinib can help children with hard-to-treat leukemias, lymphomas, or solid tumors feel better and have more treatment options.

  Recruiting at 22 sites Phase 1/2 Incyte Corporation · Ghent and 22 other locations · NCT03934372

• Mobile app to help teens and young adults take their daily oral leukemia medicine

  This project tests a smartphone app that sends tailored reminders and messages to help adolescents and young adults with acute lymphoblastic leukemia or lymphoblastic lymphoma take their daily 6-mercaptopurine during maintenance therapy.

  Recruiting Northwestern University · Chicago, Illinois · NCT03932903

• Using CD45RA Depleted Stem Cells to Improve Immune Recovery After Transplant

  This study is testing if using special stem cells can help patients with acute leukemia recover their immune system faster after a transplant and reduce the risk of complications.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT03810196

• Evaluating Orca-Q in patients receiving stem cell transplants for blood cancers

  This study is testing a new type of donor graft called OrcaGraft to see if it can make stem cell transplants safer and more effective for people with blood cancers like leukemia.

  Recruiting at 9 sites Phase 1 Orca Biosystems, Inc. · Duarte, California and 11 other locations · NCT03802695

• CLIC-1901 treatment for relapsed/refractory CD19 positive blood cancers

  This study is testing a new treatment called CLIC-1901 for people with hard-to-treat blood cancers to see if it can help them feel better.

  Recruiting at 2 sites Phase 1/2 Ottawa Hospital Research Institute · Vancouver, British Columbia and 2 other locations · NCT03765177

• Combining ruxolitinib with chemotherapy for young patients with Ph-like acute lymphoblastic leukemia

  This study is testing if adding a drug called ruxolitinib to standard chemotherapy can help young patients with a specific type of leukemia feel better and improve their treatment results.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois and 1 other locations · NCT03571321

• Genetic factors affecting liver damage from asparaginase in leukemia patients

  This study is testing how certain genes might affect the risk of liver damage from asparaginase in people newly diagnosed with acute lymphoblastic leukemia.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT03568266

• Expanded/activated gamma delta T-cell infusions after haploidentical stem cell transplant with post-transplant cyclophosphamide.

  This tests whether infusing expanded/activated gamma delta T cells after a partially matched (haploidentical) stem cell transplant with post-transplant cyclophosphamide helps control leukemia and reduce graft-versus-host disease in adults.

  Recruiting at 2 sites Phase 1 University of Kansas Medical Center · Westwood, Kansas and 1 other locations · NCT03533816

• HA-1 TCR T cell therapy for leukemia that returned or didn't respond after a donor stem cell transplant

  This Phase 1 study will test whether giving specially engineered donor T cells called HA-1 TCR T cells is safe and what dose works for people whose acute leukemia came back or didn't respond after a donor stem cell transplant.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03326921

• Hematopoietic stem cell transplant for blood cancers

  This study is testing two different ways of doing stem cell transplants for people with blood cancers to see which method works better and is safer.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT03314974

• Combining blinatumomab, methotrexate, cytarabine, and ponatinib for treating certain types of leukemia

  This study is testing a new combination of four medications to see if it can help people with certain types of leukemia that have come back or didn't respond to previous treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT03263572

• Using radioactive treatment before stem cell transplant for high-risk leukemia patients

  This study is testing a new radioactive treatment given before a stem cell transplant to see if it can help high-risk leukemia patients by targeting cancer cells while protecting healthy ones.

  Recruiting Phase 1/2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03128034

• Registry for collecting data on adult Acute Lymphoblastic Leukemia patients

  This study is collecting information from adults with Acute Lymphoblastic Leukemia to see how well different treatments work and to improve care for future patients.

  Recruiting at 147 sites Goethe University · Graz and 146 other locations · NCT02872987

• Personalized NK cell therapy after umbilical cord blood transplant for leukemia

  This study is testing if a special treatment using personalized immune cells from umbilical cord blood can help people with leukemia feel better after their transplant.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT02727803

• Transplantation with modified stem cells and Zoledronate for pediatric cancers

  This study is testing a new way to use modified stem cells and a drug called Zoledronate to see if it can safely help children with tough-to-treat cancers.

  Recruiting Phase 1 University of Wisconsin, Madison · Madison, Wisconsin · NCT02508038

• Immunotherapy using CAR T-cells for treating high-risk acute lymphoblastic leukaemia

  This study is testing a new type of immune therapy using specially modified T-cells to see if it can help children and young adults with high-risk leukemia feel better and stay in remission longer.

  Recruiting at 3 sites Phase 1 University College, London · London and 2 other locations · NCT02443831

NIH-funded research (newest 40 of 82)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Caregiver-led mobile tool to support healthy habits for kids treated for ALL

  A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11630804

• Genomics of childhood ALL across global populations

  A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11608541

• Genomics of childhood ALL across diverse populations

  A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11608540

• Combinatorial targeting for high-risk B-cell ALL treatment

  A research effort at West Virginia University is exploring a combination therapy for adult B-cell acute lymphoblastic leukemia using targeted gene silencing and a small-molecule compound to improve treatment in patients.

  NIH research West Virginia University · Morgantown, United States · NIH-11579281

• Understanding why Latino children have a higher risk of childhood ALL

  This project looks at why Latino children are more likely to develop acute lymphoblastic leukemia and whether genetic ancestry plays a role, with the goal of improving prevention and outcomes.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11520852

• Targeting obesity to improve survival for children with ALL

  A new approach explores whether reducing obesity-related factors can make chemotherapy work better for kids with acute lymphoblastic leukemia.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11474567

• TBL-1 and Wnt signaling in pediatric B- and T-cell ALL

  A project explores whether blocking TBL-1 can make pediatric B- and T-cell acute lymphoblastic leukemia easier to treat, especially after relapse.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11451103

• NSD2-NEO1 pathway and CNS spread of childhood ALL

  A pediatric leukemia study looks at how a gene mutation helps leukemia cells reach the brain, with the aim of finding targeted, less toxic treatments.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11447279

• Molecular categorization of pediatric T-ALL using big data and AI

  A pediatric leukemia grant that uses AI and big data from kids’ research to classify T-ALL subtypes and guide future treatments.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11442534

• Radiation and Heat and Childhood Leukemia in Kids

  A small, patient-friendly study will explore whether exposure to heat and sunlight in early childhood is linked to childhood leukemia and related genetic changes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11436968

• Disparities in childhood ALL: how patients' reports, biology, and neighborhoods shape outcomes

  This project explores why Latino children with acute lymphoblastic leukemia have worse outcomes by looking at patient-reported experiences, epigenetic patterns, and neighborhood factors.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420849

• Pharmacogenomics to tailor ALL treatment for Latino kids

  A research program will study how genetic differences affect how Latino children with acute lymphoblastic leukemia respond to treatment, with the aim of guiding safer, more effective care.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420847

• Understanding why some children with ALL have more side effects from methotrexate and how it affects their health

  This project looks at why Latino children with acute lymphoblastic leukemia experience more neurotoxicity from methotrexate and how that affects their short- and long-term outcomes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420843

• Genomics of childhood acute lymphoblastic leukemia across global populations

  This grant studies how inherited genes influence the risk of childhood ALL around the world to understand why some groups are more affected.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11413497

• Childhood acute lymphoblastic leukemia genetics around the world

  This project compares inherited genetic differences in children with and without acute lymphoblastic leukemia across many countries to learn who is at higher risk.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11407900

• Genetics of childhood acute lymphoblastic leukemia

  This project looks at how inherited genes affect the risk of acute lymphoblastic leukemia in children from many countries and ancestry groups.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11407899

• Pediatric ALL: using new targeted therapies to improve outcomes for relapsed and newly diagnosed disease

  A pediatric oncologist-led effort is testing how using new targeted therapies, including antibody-based and CAR-T approaches, can improve outcomes for children and young people with relapsed or newly diagnosed acute lymphoblastic leukemia.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11399083

• Preventing fatal infections in children with Down syndrome during ALL treatment

  Aimed at reducing deadly infections in children with Down syndrome undergoing chemotherapy for acute lymphoblastic leukemia by finding biomarkers to tailor treatment and supportive care.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11398896

• Understanding how PAX5 mutations drive B-ALL in adults

  A research team is studying how changes in the PAX5 gene affect a type of blood cancer called B-ALL in adults, using human samples and experimental models to uncover new angles for treatment.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11396190

• New gene clue for a high-risk B-ALL (Ph/Ph-like)

  Researchers are studying a newly identified gene, A978, to understand why certain aggressive B-ALL types resist standard therapy and how targeting this gene could improve outcomes.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11394431

• Improving CAR T-cell therapy for pediatric B-ALL

  A physician-scientist at St. Jude aims to advance CAR T-cell therapy for children with high-risk B-ALL by testing new donor-derived and enhanced autologous CAR T-cell approaches in early-phase trials.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11386624

• Tracking therapy-resistant changes in childhood leukemia

  This project looks at how to identify molecular clues at diagnosis that predict which children with ALL might relapse, so doctors can tailor therapies to reduce late effects and improve outcomes.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11384571

• Markers of neurocognitive changes during chemotherapy in children with ALL

  A research project looks at how chemotherapy affects thinking skills in kids with acute lymphoblastic leukemia, to help families understand and guide care.

  NIH research Arkansas Children's Hospital Res Inst · Little Rock, United States · NIH-11382024

• Understanding how microRNA degradation affects T-cell leukemia therapy

  This grant studies how specific microRNAs are degraded in T-cell acute lymphoblastic leukemia (T-ALL) and how this might boost chemotherapy effectiveness.

  NIH research University of Florida · Gainesville, United States · NIH-11365118

• Transcriptomic risk classification for children with B cell ALL

  This grant tests a RNA-based test to better predict relapse risk for kids with B-ALL so doctors can tailor treatments.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11350055

• Mutational clues to childhood ALL in California

  Researchers are studying how mutations in childhood acute lymphoblastic leukemia relate to environmental exposures in California to help prevent the disease.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11346208

• Cytomegalovirus and childhood leukemia: could a common virus influence ALL in babies and kids

  Aims to understand whether neonatal CMV infection is linked to a higher risk of getting childhood acute lymphoblastic leukemia and how it might shape the tumor’s genome.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11336849

• Bivalent CD47 Immunotoxin for Targeted Therapy of T-ALL in kids

  A new targeted therapy using a two-part CD47-directed toxin is being studied for children with T-cell acute lymphoblastic leukemia who have limited treatment options.

  NIH research Rock Immune, INC. · Denver, United States · NIH-11310680

• Adapting a caregiver-led mobile program to boost healthy habits in kids treated for ALL

  A caregiver-directed mobile health program helps children treated for acute lymphoblastic leukemia build healthy habits to reduce long-term heart and diabetes risk.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11295729

• What affects how daily 6-mercaptopurine works in teens and young adults with ALL

  This work looks at why some adolescents and young adults with acute lymphoblastic leukemia have lower amounts of the active 6-mercaptopurine metabolite in their body during maintenance treatment.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11285487

• Understanding inherited genetic risk variants in IKZF1 to understand and prevent childhood B-ALL

  A doctor-scientist at Boston Children’s Hospital is studying how inherited genetic differences in IKZF1 may cause or shape childhood B-ALL, with the goal of guiding better prevention and treatment in the future.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11281299

• Helping kids with ALL manage pain without relying only on opioids

  A pediatric-focused grant aims to identify what drives pain during ALL treatment and build a non-drug pain program to help children feel better.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11273555

• Blocking fatty acid uptake to help CAR-T work better for relapsed B‑cell ALL

  This research looks at whether stopping leukemia cells from taking up fatty acids can help CD19 CAR‑T therapy work better for children and young adults with relapsed B‑cell acute lymphoblastic leukemia.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11261188

• Understanding how T-cell acute lymphoblastic leukemia avoids the immune system and finding new treatments.

  This study is looking at how T-cell acute lymphoblastic leukemia (T-ALL) manages to hide from the immune system, which makes it tough to treat, especially when it comes back, and it hopes to find new ways to help improve treatments for patients like you by understanding how leukemia cells interact with immune cells.

  NIH research University of Utah · Salt Lake City, United States · NIH-11229540

• New targeted treatments for children with acute lymphoblastic leukemia

  Combining newer targeted drugs and precision medicine to help children and young adults with relapsed or high‑risk acute lymphoblastic leukemia live longer and have fewer side effects.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11194983

• Treating resistant cell groups in childhood T‑cell leukemia

  Researchers are testing targeted treatments to find and destroy rare, treatment‑resistant leukemia cells in children with T‑cell acute lymphoblastic leukemia.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11180396

• Tracking brain and thinking changes during childhood leukemia treatment

  This project follows young children with acute lymphoblastic leukemia to find early signs of changing brain development and thinking skills during chemotherapy.

  NIH research Arkansas Children's Hospital Res Inst · Little Rock, United States · NIH-11168983

• Tracking treatment-resistant changes in childhood acute lymphoblastic leukemia

  Looking at genetic changes linked to treatment resistance in children with acute lymphoblastic leukemia to see if they can predict who will relapse.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11167570

• Understanding how genetic changes in the ETV6 gene lead to childhood leukemia

  This study is looking at how certain genes, especially the ETV6 gene, might play a role in causing acute lymphoblastic leukemia (ALL) in kids, especially those with a family history of low platelet counts, to help find better ways to treat the disease.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11163330

• Investigating the link between cytomegalovirus and childhood leukemia

  This study is looking at how being infected with a virus called neonatal cytomegalovirus (nCMV) might raise the chances of kids developing a type of cancer called acute lymphoblastic leukemia (ALL), and it’s for families who want to understand more about the possible links between this virus and leukemia.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11144293

Related topics

Quick answers

How many Acute Lymphoblastic Leukemia clinical trials are recruiting right now?

113, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 46 countries. The most sites are in United States (61 trials), China (20 trials), France (9 trials), Spain (7 trials), Italy (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 32, Phase 1: 21, Phase 1/2: 15, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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