Investigating a specific type of leukemia in children caused by genetic changes.
Official title: Experimental and preclinical modeling of NUP98-rearranged acute leukemia
Funded at St. Jude Children's Research Hospital · NIH-9834651 · Data updated 2026-11-12
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 19, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2019 |
| Award (this year) | $9,965,625 |
| NIH project number | 1U54CA243124-01 |
| Project ID | NIH-9834651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with acute erythroleukemia or acute megakaryoblastic leukemia associated with NUP98 rearrangements.
✕Less likely to help
Patients with other types of leukemia or those who do not have NUP98 rearrangements may not benefit from this research.
What this research studies
This research focuses on understanding the role of NUP98 fusion oncoproteins in high-risk myeloid leukemias, particularly in children and adolescents. By developing and studying human and mouse models, the team aims to uncover the molecular mechanisms behind these leukemias and identify potential treatment vulnerabilities. The project involves a consortium of experts who will explore various aspects of leukemia biology, including chromatin dynamics and drug development, to create more effective therapies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for children with NUP98-rearranged leukemias.
How similar studies have gone: While the specific focus on NUP98 rearrangements is novel, similar approaches in studying genetic alterations in leukemia have shown promise in other contexts.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Mullighan, Charles G. — St. Jude Children's Research Hospital
- Study coordinator: Mullighan, Charles G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.