Assessing cognitive effects of whole brain radiation therapy in blood cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the neurocognitive outcomes of patients with hematologic malignancies who receive whole brain radiation therapy (WBRT). It aims to record cognitive function using standard neurocognitive tests and assess quality of life through validated questionnaires. Additionally, the study will explore MRI changes in the brain post-WBRT and investigate the role of Memantine on cognitive outcomes. Patients will undergo assessments at baseline, and then at 2, 6, 12 months, and annually for 5 years after treatment completion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Treatment with radiation therapy to the brain for a hematologic malignancy (ex. primary central nervous system lymphoma \[PCNSL\], secondary central nervous system lymphoma \[SCNSL\], leukemia, myeloma)
* Proficient and capable of completing tests in English
* Patients with claustrophobia are eligible if the claustrophobia is managed with medication
* Patients with cognitively-impairment are eligible if the impairment is managed with medication
* Patients who are pregnant

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Bouthaina S Dabaja — M.D. Anderson Cancer Center
• Study coordinator: Dustin M Silk
• Email: dmdmsilk@mdanderson.orgsilk@mdanderson.org
• Phone: 713-563-3090

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.