New treatment to improve cord blood engraftment in children with leukemia after transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate a novel post-transplant regimen of PT/FLU+CY to enhance the engraftment of unrelated cord blood in children undergoing hematopoietic stem cell transplantation (HSCT) for leukemia. The study focuses on the unpredictable nature of graft engraftment in haploidentical cord blood transplants and seeks to determine if this new approach can improve outcomes. By utilizing a combination of medications, the trial hopes to promote better integration of the cord blood grafts, potentially leading to improved patient recovery and survival rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* children acute leukemia

Exclusion Criteria:

* MODS

Where it's running

• Nanfang Hospital
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Xiaoqin Feng, MD — Department of Pediatrics, Nanfang Hospital, Southern Medical University
• Study coordinator: Yongsheng Ruan, MD
• Email: vimmer@smu.edu.cn
• Phone: 02062787966

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Improving outcomes for stem cell transplant patients using an intervention website

  This study is testing if a special website can help adults with blood cancer feel better and improve their quality of life after a stem cell transplant compared to a regular educational website.

  Recruiting at 3 sites Northwestern University · Washington D.C., District of Columbia and 2 other locations · NCT06960993

• Genetics of Blood Cancers in the U.S. population

  This study tests how genetic factors relate to blood cancers by collecting saliva DNA and online health surveys from at least 10,000 U.S. adults.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07714044

• Strength Training for Kids with Acute Lymphoblastic Leukemia and Lymphoblastic L lymphoma

  Researchers are testing a structured strength-training program for children and teens recently diagnosed with ALL or lymphoblastic lymphoma to see if it helps with weight gain and physical function during treatment.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07634653

• Cord blood transplant for children and young adults with blood cancers.

  This study will test whether a cord blood transplant given as a first or second transplant can help children and young adults with leukemia, myelodysplasia, or lymphoma who lack a matched donor.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT07566377

• Cohort for people with chronic myelomonocytic leukemia

  This project will collect blood and bone marrow samples from adults with chronic myelomonocytic leukemia at diagnosis and during disease changes to create an anonymized biobank researchers can use to test new questions.

  Recruiting Gustave Roussy, Cancer Campus, Grand Paris · Amiens and 23 other locations · NCT07512882

• Triple-drug approach for AML using eganelisib with azacitidine and venetoclax

  This early-stage trial tests whether adding eganelisib to azacitidine and venetoclax can be safe and show signs of benefit in adults with acute myeloid leukemia.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07439211

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.