Condition

Acute Leukemia clinical trials and research

• 48Clinical trials
• 24NIH research projects
• 2New in 30 days
• 17Countries

Newest Acute Leukemia clinical trials

All recruiting trials (48)

• Menin inhibitors in pediatric relapsed or refractory acute leukemia

  This study looks at kids with relapsed or treatment-resistant acute leukemia who have specific genetic changes and are treated with menin inhibitors to see how they fare.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07898436

• Artistic and movement activities to help anxiety in kids with ALL

  Kids aged 8–13 with acute lymphoblastic leukemia test whether a 16-session art and movement program can reduce anxiety compared with standard care.

  Recruiting Phase 3 Children's Cancer Hospital Egypt 57357 · Cairo, Cairo Governorate · NCT07878065

• Strength Training for Kids with Acute Lymphoblastic Leukemia and Lymphoblastic L lymphoma

  Researchers are testing a structured strength-training program for children and teens recently diagnosed with ALL or lymphoblastic lymphoma to see if it helps with weight gain and physical function during treatment.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07634653

• QUAIL-100 in kids and young adults after stem cell transplant with high-risk blood cancers

  This study tests QUAIL-100 in pediatric and young adult patients who have high-risk acute leukemia or myelodysplastic syndrome and have already received a partially matched stem cell transplant.

  Recruiting Phase 1 Laguna Biotherapeutics, Inc. · Palo Alto, California · NCT07573111

• Thiotepa-based Conditioning With Reduced Post-Transplant Cyclophosphamide for Allogeneic Stem Cell Transplant in High-Risk Blood C cancers

  This phase 1 trial tests a Thiotepa, Busulfan, and Fludarabine conditioning regimen with de-escalated post-transplant cyclophosphamide to see if it can improve outcomes after allogeneic stem cell transplantation for high-risk blood cancers.

  Recruiting Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07565220

• Menin inhibitor maintenance after allogeneic stem cell transplant

  This project will try menin inhibitor maintenance to see if it helps people with acute leukemia after allogeneic stem cell transplant who have KMT2A or related gene changes.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07559695

• Formalized nurse-led care support after an acute leukemia diagnosis

  This trial will test whether a structured nurse-led support visit after being told you have acute leukemia can reduce anxiety for adult patients hospitalized at Centre Henri Becquerel.

  Recruiting Centre Henri Becquerel · Rouen · NCT07499765

• Reduced-intensity donor stem cell transplant with treosulfan/fludarabine and post-transplant cyclophosphamide for leukemia and MDS

  This trial tests a lower-intensity donor stem cell transplant using treosulfan plus fludarabine with post-transplant cyclophosphamide to try to reduce toxicity and prevent graft-versus-host disease in people aged 2–75 with acute leukemias or myelodysplastic syndromes.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT07493538

• Chemogenomic profiling for blood cancers

  This project will test whether detailed genetic and molecular profiling of bone marrow, blood, or tissue samples can better characterize diagnosis and relapse for people with suspected or known blood cancers.

  Recruiting Azienda Ospedaliero-Universitaria di Parma · Parma, PR · NCT07445984

• Multi-omics testing for blood and bone marrow cancers

  This project will test a multi-omics lab approach on bone marrow, blood, biopsy and other fluid samples from people with suspected or known hematologic cancers to see if it can better characterize their disease.

  Recruiting Azienda Ospedaliero-Universitaria di Parma · Parma, PR · NCT07445438

• Comprehensive multi-omics and functional profiling to fully characterize tumors

  This project tests whether detailed multi-omics and functional testing of tumor samples can better characterize high-risk blood and solid cancers for patients at participating centers.

  Recruiting at 2 sites Azienda Ospedaliero-Universitaria di Parma · Palermo, Palermo and 1 other locations · NCT07403630

• Luspatercept to treat anemia after donor stem cell transplant

  This trial will try luspatercept in people with acute leukemia who have anemia after an allogeneic (donor) stem cell transplant to see if it raises hemoglobin without transfusions.

  Recruiting Phase 1/2 Zhujiang Hospital · Guangzhou, Guangdong · NCT07362095

• Revumenib with Mezigdomide for relapsed or refractory acute leukemia

  This trial will test whether combining revumenib and mezigdomide is safe for people aged 12 and older with relapsed or refractory acute leukemia that has KMT2A, NUP98, or NPM1 genetic changes.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Duarte, California and 9 other locations · NCT07356154

• BY002 for relapsed or refractory acute leukemia with KMT2A rearrangements or NPM1 mutations

  This trial tests an oral menin inhibitor, BY002, in adults with relapsed or refractory AML, ALL, or MPAL who have KMT2A rearrangements or NPM1 mutations to see if it is safe and shows early signs of benefit.

  Recruiting Phase 1 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07270770

• BN104 maintenance after allogeneic stem cell transplant for acute leukemia

  This trial tests whether taking the oral menin inhibitor BN104 can reduce relapse in people with acute leukemia who have specific genetic changes and are 1–6 months after an allogeneic stem cell transplant.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07101497

• Lower-dose ATG plus mini post‑transplant cyclophosphamide to prevent GVHD after haploidentical stem cell transplant

  This approach tries a lower dose of ATG combined with a short course of post‑transplant cyclophosphamide to prevent graft‑versus‑host disease in people aged 12–65 receiving a haploidentical stem cell transplant for acute leukemia or myelodysplastic syndrome.

  Recruiting Phase 2 Peking University People's Hospital · Beijing · NCT06984536

• Evaluating health and nutrition in acute leukemia patients during chemotherapy

  This study is trying to see how patients with acute leukemia feel and perform physically and mentally during chemotherapy, and how their nutrition affects their quality of life.

  Recruiting University of Rome Tor Vergata · Rome, RM · NCT06937554

• Testing a web application to help patients with acute leukemia

  This study is testing a new web app to see if it can help people with acute leukemia find and join clinical trials more easily.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT06907797

• Understanding the immune system and metabolism in patients with acute leukemia

  This study looks at how the immune system and metabolism change in people with acute leukemia before and after treatment to see how these changes affect their response to therapy.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06814444

• Comparing two doses of total body irradiation for leukemia patients undergoing stem cell transplant

  This study is testing whether a lower or higher dose of total body radiation helps leukemia patients doing a stem cell transplant have better chances of staying healthy and not relapsing.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06803745

• Investigating serum ferritin as a biomarker for immune-related adverse events

  This study is testing if a blood marker called serum ferritin can help doctors identify and predict immune-related side effects in patients with cancer receiving different types of treatment.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06702566

• Using virtual reality to reduce pain and anxiety during needle placements in children with leukemia

  This study tests if using virtual reality can help reduce pain and anxiety for kids with leukemia during needle placements.

  Recruiting at 4 sites University Hospital, Clermont-Ferrand · Bordeaux and 3 other locations · NCT06697275

• Using CD7 CAR-T cells to treat relapsed or refractory acute leukemia

  This study is testing a new type of CAR-T cell therapy to see if it can help people with relapsed or hard-to-treat acute leukemia feel better and improve their chances of survival.

  Recruiting Phase 1/2 The General Hospital of Western Theater Command · Chengdu, Sichuan · NCT06585345

• Using revumenib to treat acute leukemia after stem cell transplant

  This study is testing a new drug called revumenib to see if it can help people with acute leukemia feel better after they’ve had a stem cell transplant.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06575296

• Brain imaging in young patients with acute leukemia

  This study is testing how chemotherapy affects the brains of children and young adults with acute leukemia to see if it causes any thinking problems and to find ways to help them.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06421155

• Two-step ATG to prevent GVHD after myeloablative allogeneic stem cell transplant

  This study tests whether a two-step dosing of rabbit ATG added to tacrolimus and low-dose methotrexate can help prevent severe acute and chronic GVHD in adults 18–60 receiving myeloablative allogeneic peripheral blood stem cell transplants for leukemia, MDS, or myeloproliferative disorders.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT06315309

• Preventing Acute GVHD After Stem Cell Transplant

  This study is testing a new way to give a medication before and during stem cell transplants to see if it can help prevent a serious condition called acute GVHD in patients.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT06265584

• Monitoring residual disease in leukemia patients after stem cell transplantation

  This study is testing a new digital method to see if it can better track leftover leukemia cells in patients after they receive a stem cell transplant compared to older methods.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT06211166

• Investigating a new drug combination for relapsed acute lymphoblastic leukemia

  This study is testing a new combination of drugs to see if it can safely help patients with relapsed acute lymphoblastic leukemia feel better and improve their treatment outcomes.

  Recruiting at 2 sites Phase 1/2 University of Chicago · Chicago, Illinois and 1 other locations · NCT06207123

• Examining the link between donor telomere length and outcomes in acute leukemia patients after stem cell transplantation

  This study is trying to see if the length of telomeres in blood from stem cell donors can affect how well patients with acute leukemia do after their transplant.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT06076226

• Rifaximin to improve gut bacteria after allogeneic stem cell transplant for acute leukemia

  This trial tests whether taking oral rifaximin around the time of an allogeneic stem cell transplant helps preserve healthy gut bacteria and reduces infections, graft‑versus‑host disease, and death in adults with acute leukemia.

  Recruiting Phase 2 Tata Memorial Centre · Navi Mumbai, Maharashtra · NCT06058572

• Examining the safety of ziftomenib combinations for patients with relapsed acute myeloid leukemia

  This study is testing if combining ziftomenib with standard treatments can safely help people with relapsed acute myeloid leukemia feel better and improve their chances of recovery.

  Recruiting at 43 sites Phase 1 Kura Oncology, Inc. · Gilbert, Arizona and 44 other locations · NCT06001788

• Evaluating Haplo-HSCT for Elderly Patients with Acute Leukemia or Myelodysplastic Syndrome

  This study is testing a gentler stem cell transplant method for older patients with acute leukemia or myelodysplastic syndromes who don't have a matched donor, to see if it helps them live longer and stay healthier after the procedure.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT05902416

• T cell receptor depletion for blood cancer treatment

  This study is testing a new way to treat blood cancers by using a special treatment before a stem cell transplant to see if it helps both kids and adults do better after the procedure.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05735717

• Treatment of FGFR1-rearranged neoplasms with Olverembatinib

  This study is testing if a new drug called Olverembatinib can help people with rare blood cancers caused by FGFR1 changes get better and possibly prepare them for a stem cell transplant.

  Recruiting Phase 2 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT05521204

• Using GnRHa to protect fertility during chemotherapy for young women

  This study is testing if a hormone treatment can help young women keep their ability to have children while they undergo chemotherapy for cancer.

  Recruiting at 4 sites Phase 3 Karolinska University Hospital · Gothenburg and 16 other locations · NCT05328258

• Testing bleximenib for treating acute leukemia

  This study is testing a new drug called bleximenib to see if it can safely help teenagers and adults with tough cases of acute leukemia.

  Recruiting at 85 sites Phase 1/2 Janssen Research & Development, LLC · Duarte, California and 101 other locations · NCT04811560

• A program to support emotional and physical health in patients with acute leukemia

  This study tests if a new support program that includes therapy and symptom checks can help people newly diagnosed with acute leukemia feel better emotionally and physically compared to standard care alone.

  Recruiting at 5 sites Canadian Cancer Trials Group · Saint John, New Brunswick and 5 other locations · NCT04224974

• Donor stem cell transplant with chemotherapy and radiation for blood cancers

  This study is testing if a donor stem cell transplant combined with different doses of chemotherapy and radiation can help people with blood cancers recover better.

  Recruiting Phase 2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT04195633

• Intensity Modulated Total Marrow Irradiation for Acute Leukemia and MDS

  This study is testing a new type of radiation treatment before a stem cell transplant to see if it helps people with acute leukemia or myelodysplastic syndromes do better.

  Recruiting Phase 2 University of Illinois Chicago · Chicago, Illinois · NCT04187105

• Monitoring blood markers in elderly patients with acute leukemia after chemotherapy

  This study is testing if measuring certain blood markers can help doctors understand how well chemotherapy is working for older patients with acute leukemia.

  Recruiting Navy General Hospital, Beijing · Beijing · NCT04157569

• Stem cell transplantation for blood disorders using specific cell depletion techniques

  This study is testing a new way of using stem cell transplants for children and young adults with blood disorders to see if removing certain cells helps them recover better and improve their quality of life.

  Recruiting Phase 2 New York Medical College · Valhalla, New York · NCT04099966

• Strategies to reduce graft versus host disease in blood stem cell transplant patients with acute leukemia or MDS

  This study is testing two different treatment plans to see which one better helps prevent graft versus host disease in patients with acute leukemia or myelodysplastic syndrome after they receive a blood stem cell transplant.

  Recruiting at 3 sites Phase 2 Fred Hutchinson Cancer Center · Tampa, Florida and 2 other locations · NCT03970096

• Using CD45RA Depleted Stem Cells to Improve Immune Recovery After Transplant

  This study is testing if using special stem cells can help patients with acute leukemia recover their immune system faster after a transplant and reduce the risk of complications.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT03810196

• Hematopoietic stem cell transplant for blood cancers

  This study is testing two different ways of doing stem cell transplants for people with blood cancers to see which method works better and is safer.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT03314974

• Investigating genetic factors in childhood cancer

  This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT03050268

• Transplanting umbilical cord blood from unrelated donors

  This study is testing different ways to prepare patients for umbilical cord blood stem cell transplants to see how safe and effective the procedure is for them.

  Recruiting University of Rochester · Rochester, New York · NCT03016806

• Understanding barriers to stem cell transplantation in acute leukemia patients

  This study looks at why some patients with acute leukemia, myelodysplastic syndromes, or myeloproliferative neoplasms choose to have or skip stem cell transplants, even when their doctors recommend it.

  Recruiting at 2 sites Memorial Sloan Kettering Cancer Center · Hartford, Connecticut and 2 other locations · NCT02677064

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating a specific type of leukemia in children caused by genetic changes.

  This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-9834651

• Reducing leukemia disparities in Latino children and teens

  A large, multi-project effort aims to understand why Latino children with acute lymphoblastic leukemia have worse outcomes and how to reduce those gaps.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11420825

• Genomic advances to improve outcomes in high-risk acute leukemia

  A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11413510

• Understanding and Targeting Extramedullary Acute Leukemia

  A clinician-research team is studying myeloid sarcoma, a form of AML that forms solid tumors outside the bone marrow, to develop new treatments for patients.

  NIH research New York University School of Medicine · New York, United States · NIH-11391429

• Diversifying acute leukemia trial enrollment through multilevel approach

  Aiming to broaden participation in acute leukemia trials by testing a multi-layer plan that addresses barriers for adults with AML.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11362223

• Blocking menin to treat acute leukemias with high HOX gene activity

  This work develops new drugs that block a protein called menin to help people with certain aggressive acute leukemias driven by HOX gene activation.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11312667

• Predicting methotrexate-related brain side effects in children with ALL

  This project works to predict which children and teens with acute lymphoblastic leukemia will develop methotrexate-related neurotoxicity using clinical signs and biological data.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11305990

• How mRNA stability affects blood cell development and acute myeloid leukemia

  This work looks at whether problems in RNA stability in blood cells drive acute myeloid leukemia and could point to new treatments for adults and children with AML.

  NIH research New York University School of Medicine · New York, United States · NIH-11249176

• Using genetic discoveries to improve outcomes for high-risk acute leukemia

  Researchers are using genetic information from people with high-risk acute leukemia to find why the cancer starts and why some treatments fail so they can create better tests and targeted therapies.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11210476

• Turning genetic discoveries into better care for high-risk acute leukemia

  Researchers are using genetic information to find new tests and targeted treatments for children and young people with high‑risk acute leukemia.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11178425

• Improving Access to Acute Leukemia Clinical Trials for Diverse Patients

  This effort aims to help more Black and Hispanic adults with acute leukemia join clinical trials, ensuring everyone has a fair chance at new treatments.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11109703

• Understanding how changes in DNA structure affect treatment outcomes in children with leukemia

  This study is looking at how changes in the way DNA is organized can affect how well treatments work for kids with B cell acute leukemia, with the hope of finding better ways to help them feel better.

  NIH research New York University School of Medicine · New York, United States · NIH-11082275

• Targeting a protein interaction to improve treatment for acute leukemia

  This study is looking at how two proteins, menin and MLL1, work together in acute leukemia, and it's testing new medicines that could help patients, especially those with tough genetic challenges, by blocking this interaction to improve their treatment options and outcomes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11078720

• Investigating how oncoproteins affect cell behavior in acute leukemia

  This study is looking at how certain proteins linked to the KMT2A gene affect leukemia cells, helping us understand why some cells change and might resist treatment, with the goal of finding better therapies for patients with tough-to-treat leukemia.

  NIH research Van Andel Research Institute · Grand Rapids, United States · NIH-11076739

• Predicting neurotoxicity from methotrexate in children with leukemia

  This study is looking at how certain biological factors might help us understand why some children, especially Latino kids, may experience more side effects from their leukemia treatment with methotrexate, so we can find ways to improve their care and outcomes.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11063802

• Understanding how 3D chromatin changes in acute leukemia

  This study is looking at how changes in DNA structure in people with acute leukemia can affect how genes work and may lead to challenges like drug resistance and relapse, with the hope of finding new ways to treat the disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11059139

• Investigating how mRNA stability affects blood cell development and leukemia

  This study is looking at how certain proteins affect blood cell development in people with acute myeloid leukemia (AML), with the goal of finding new treatments that could help both kids and adults with this type of cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11003300

• Improving diversity in clinical trials for acute leukemia treatments

  This study is looking at why fewer Black and Hispanic adults with acute leukemia join clinical trials and aims to find ways to make it easier for everyone to participate, so that all patients can access the best treatments available.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10874675

• Understanding and treating a specific type of acute leukemia caused by NUP98 gene changes

  This study is looking at a tough type of leukemia called NUP98-rearranged acute leukemia to find better ways to understand and treat it, using new techniques to see how certain genetic changes cause the disease and what new treatments might help patients like you.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-10829603

• Quickly identifying genetic mutations in acute myeloid leukemia using advanced sequencing techniques

  This study is testing a new, faster way to find genetic changes in acute myeloid leukemia (AML) to help doctors quickly understand how serious the disease is and choose the best treatment for patients.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10815759

• Creating new treatments for acute leukemia by targeting specific genes

  This study is looking at a new way to help people with acute myeloid leukemia (AML) by testing a treatment that targets a specific protein to lower the activity of certain genes linked to the disease, and patients may have the chance to participate in trials to see how well this treatment works.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10740903

• Understanding how specific sugars on leukemia cells affect blood cancer development

  This study is looking at a special sugar on leukemia cells to see how it helps these cells stick to blood vessels, which could lead to new ways to treat blood cancers like leukemia.

  NIH research Florida International University · Miami, United States · NIH-10646189

• Investigating a specific genetic change in childhood leukemia

  This study is looking at how changes in a specific gene might contribute to aggressive types of leukemia in kids and teens, with the goal of finding new treatments that could help young patients.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-10230523

• Investigating a specific genetic alteration in childhood leukemia

  This study is looking at how certain proteins linked to leukemia in kids and teens work, so researchers can find new ways to treat this tough disease.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-10228882

Related topics

Quick answers

How many Acute Leukemia clinical trials are recruiting right now?

48, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (24 trials), China (13 trials), Italy (6 trials), France (4 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Phase 1/2: 5, Phase 1: 5, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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