Investigating early ageing in young cancer patients during treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess early ageing and cellular senescence in adolescent and young adult (AYA) cancer patients aged 18-39 years. It involves a longitudinal cohort design where participants will undergo blood sampling before starting systemic therapy and again one year later. The study seeks to identify markers related to early vascular ageing and understand the impact of cancer treatment on long-term health outcomes, particularly cardiovascular disease. By focusing on this under-researched population, the study hopes to fill gaps in knowledge regarding the long-term effects of cancer therapies on AYA patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18-39 years at cancer diagnosis
* Having a histologically and/or cytologically confirmed cancer diagnosis, including leukemia, (non-)Hodgkin lymphoma, testicular cancer, osteosarcoma, Ewing sarcoma, breast cancer, and cervical cancer.
* Scheduled to start systemic therapy with curative intent. Allowed treatments (concurrent or sequential) are: surgery, radiotherapy, chemotherapy, antibodies.

Exclusion Criteria:

* patients who are not able to understand the patient information letter and informed consent form
* patients who will be treated with immune checkpoint inhibitors or targeted therapy with inhibitors of angiogenesis
* patients who have been treated with systemic therapy or radiotherapy for a previous malignancy (exceptions: in situ carcinoma of the cervix or uterus and adequately treated basal and squamous cell carcinoma of the skin).

Where it's running

• University Medical Center Groningen
  Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: J. Nuver, MD, PhD — University Medical Center Groningen
• Study coordinator: J. Nuver, MD, PhD
• Email: j.nuver@umcg.nl
• Phone: +31 50 361 2821

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.