Condition
Hodgkin Lymphoma clinical trials and research
Research outlook What's coming for Hodgkin lymphoma: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 64 Hodgkin Lymphoma clinical trials that are recruiting, at sites in 27 countries (most in United States (38), Italy (6), Australia (5)). By phase: Phase 2 (24), Phase 1 (10), Phase 1/2 (6), Phase 3 (4). The most active sponsors are M.D. Anderson Cancer Center (4), Takeda (3), St. Jude Children's Research Hospital (3). There are also 31 NIH-funded research projects on Hodgkin Lymphoma, with $17.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 64Clinical trials
- 31NIH research projects
- 27Countries
Newest Hodgkin Lymphoma clinical trials
All recruiting trials (64)
-
New ways to diagnose lymphoma and multicentric Castleman disease in people living with HIV
This study tests a quick, point-of-care nucleic acid test to help diagnose lymphoma and multicentric Castleman disease in people living with HIV in sub-Saharan Africa.
-
JLM019 Injection in Adults with Advanced Cancers
This study tests JLM019 Injection in adults with advanced solid tumors or relapsed/refractory lymphomas to see if it’s safe and tolerable.
-
Cord blood transplant for children and young adults with blood cancers.
This study will test whether a cord blood transplant given as a first or second transplant can help children and young adults with leukemia, myelodysplasia, or lymphoma who lack a matched donor.
-
Nivolumab plus AVD for newly diagnosed early-stage non-bulky classical Hodgkin lymphoma in young patients
This study tests whether nivolumab added to AVD can help children, teens, and young adults with newly diagnosed early-stage non-bulky Hodgkin lymphoma.
-
Adaptive Proton Therapy for Pediatric Solid Tumors and Hodgkin Lymphoma
This study tests a regular imaging approach to see if proton therapy plans for children with solid tumors or Hodgkin lymphoma should be updated during treatment.
-
Autologous CD45 base-edited stem cells plus CART-45 cells for relapsed or refractory hematologic cancers
This phase 1 study tests whether a patient’s own edited stem cells and CART-45 cells can be given safely to treat relapsed or refractory B-cell and T-cell lymphomas and Hodgkin lymphoma.
-
CAR27/IL-15 NK cells with TGFBR2 KO for relapsed or refractory lymphoid cancers
This phase 1 basket trial tests a modified natural killer cell therapy (CAR27/IL‑15 NK cells with TGFBR2 knocked out) in adults with relapsed or refractory B-cell lymphomas, Hodgkin lymphoma, T-cell lymphomas, or B-ALL after lymphodepletion.
-
In-home cancer treatment with remote specialist support for patients in the Florida Panhandle
This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.
-
Genetic markers linked to chemotherapy-related ovarian damage in women who preserved ovarian tissue before treatment
This project will test whether genetic changes found in frozen ovarian tissue can predict which women aged 18–38 with breast cancer or Hodgkin lymphoma will develop premature ovarian insufficiency after chemotherapy.
-
PET-Guided Dose Reduction for Involved-Site Radiotherapy in Early Unfavourable Hodgkin Lymphoma
This trial tests whether reducing radiotherapy from 30 Gy to 20 Gy is safe for adults with early unfavourable Hodgkin lymphoma who achieve a metabolic complete response after two ABVD cycles.
-
Nivolumab with AVD versus PET-adapted BEACOPP-like for advanced classical Hodgkin lymphoma
This trial will test whether starting treatment with low-dose nivolumab plus AVD works better than a PET-adapted BEACOPP-like approach for adults (18–60) with advanced classical Hodgkin lymphoma.
-
12-week high-intensity interval training for recent survivors of childhood and young-adult Hodgkin lymphoma
This test tries a 12-week, remotely supervised high-intensity interval training (HIIT) program to see if recently treated survivors of childhood, adolescent, and young adult Hodgkin lymphoma can complete the program and improve fitness and health markers.
-
PET-guided first-line nivolumab plus chemotherapy for advanced Hodgkin lymphoma
This pilot trial tests whether adding nivolumab to initial chemotherapy and changing treatment based on an early PET scan helps adults with advanced classical Hodgkin lymphoma.
-
Mozobil (plerixafor) to mobilize stem cells for autologous transplant
This trial will test whether starting with G‑CSF and giving Plerixafor only when needed can collect enough stem cells for adults with multiple myeloma or lymphoma undergoing autologous transplant while possibly lowering engraftment syndrome.
-
CMV Triplex vaccine to boost immunity and prevent CMV after haploidentical stem cell transplant
This trial tests whether giving a CMV-MVA Triplex vaccine to donors and/or recipients, with or without the antiviral letermovir, can boost CMV immunity and prevent CMV viremia in people having haploidentical stem cell transplants.
-
BrECADD for stage 2B–III classical Hodgkin lymphoma
This tests the BrECADD chemotherapy combination in adults 18–60 with stage 2B (with risk factors) or stage III classical Hodgkin lymphoma and uses ctDNA to help track treatment response.
-
Carmustine treatment for lymphoma patients
This study is testing if adding a new drug called VI-0609 to a standard treatment helps lymphoma patients do better after a stem cell transplant.
-
Proton therapy for Hodgkin Lymphoma patients
This study is testing if proton therapy is a safer and effective treatment for early-stage Hodgkin Lymphoma patients who have already had chemotherapy.
-
Combining brentuximab vedotin with standard chemotherapy for Hodgkin lymphoma in adults
This study is testing if adding a new drug called brentuximab vedotin to standard chemotherapy can help adults with untreated Hodgkin lymphoma feel better and improve their treatment results.
-
Using PD-1 inhibitors to prevent relapse in Hodgkin lymphoma after stem cell transplant
This study tests whether PD-1 inhibitors can help prevent relapse in young adults with Hodgkin lymphoma after they’ve had a stem cell transplant.
-
Exploring immune responses in Hodgkin's lymphoma patients treated with pembrolizumab
This study is trying to see how the immune system of patients with relapsed Hodgkin's lymphoma responds to the treatment pembrolizumab to help improve future therapies.
-
Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues
This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.
-
Assessing lymphoma treatment response using advanced DNA analysis
This study is testing if analyzing DNA from blood can help doctors see how well treatment is working for patients with aggressive B-cell lymphoma without using radiation from scans.
-
Using Darzalex Faspro to lower antibody levels before stem cell transplant
This study is testing if a new treatment called Darzalex Faspro can help lower harmful antibodies in adults so they can safely receive a stem cell transplant for blood cancers.
-
Using Wisconsin ginseng to reduce cancer-related fatigue
This study is testing if Wisconsin ginseng can help reduce fatigue in cancer patients compared to a placebo over eight weeks.
-
Change in how kids and young adults with Hodgkin or non-Hodgkin lymphoma process medicines
This study will test whether giving small probe medicines can show changes in how children and young adults (ages 6–25) with Hodgkin or non-Hodgkin lymphoma metabolize drugs during their cancer treatment.
-
Treatment for early stage bulky Hodgkin lymphoma
This study is testing a new treatment that combines a targeted drug with standard chemotherapy to see if it helps people with early stage bulky Hodgkin lymphoma.
-
Using post-transplant cyclophosphamide and ATG for blood cancer transplants
This study is testing whether using post-transplant cyclophosphamide and ATG can help prevent graft-versus-host disease in patients with blood cancers who are getting stem cell transplants.
-
Understanding the causes and outcomes of lymphoma in Chinese patients
This study looks at the clinical and genetic details of lymphoma patients in China to see how these factors affect the disease and its outcomes.
-
Banked C7R-modified allogeneic CD30-targeted CAR T cells for CD30-positive lymphomas
This will try a donated (banked) C7R.CD30.CAR-EBVST cell infusion to treat people aged 12–75 whose CD30-positive lymphoma has returned or not responded to prior treatments.
-
Comparing JS004 and Toripalimab to Chemotherapy for Hodgkin Lymphoma
This study is testing if a new combination of JS004 and Toripalimab can work better than regular chemotherapy for people with Hodgkin lymphoma who haven't responded to previous treatments.
-
Testing CTX-8371 in patients with advanced cancers
This study is testing a new treatment called CTX-8371 in patients with advanced cancers to see if it can help them when other treatments haven't worked.
-
Evaluating AZD3470 for relapsed or refractory blood cancers
This study is testing a new drug called AZD3470 to see if it can help people with hard-to-treat blood cancers feel better and respond to treatment.
-
Study of crushed venetoclax tablets dissolved in liquid for pediatric patients
This study tests if crushing venetoclax tablets and mixing them with liquid helps children with blood cancers absorb the medication better and stay safe while taking it.
-
New cellular therapy for Hodgkin Lymphoma
This study is testing a new type of cell therapy for people with relapsed or hard-to-treat Hodgkin Lymphoma to see if it is safe and effective.
-
Vaccination to prevent CMV infection in stem cell transplant patients
This study is testing a new vaccine to see if it can help prevent CMV infections in patients receiving stem cell transplants from related donors.
-
Using Tislelizumab for Patients with Hodgkin Lymphoma Who Can't Have Standard Chemotherapy
This study is testing if a new treatment called tislelizumab can help older patients with Hodgkin lymphoma who can't take standard chemotherapy feel better and manage their disease safely.
-
Investigating cognitive impairment in young cancer patients during and after chemotherapy
This study is testing how chemotherapy affects memory and attention in children and young adults with cancer to better understand their cognitive challenges during and after treatment.
-
Improving health for lymphoma survivors through diet and exercise
This study tests if following a Mediterranean diet and doing home exercises can help lymphoma patients on chemotherapy finish their treatment and feel better during it.
-
Evaluating MT-601 for patients with relapsed or refractory lymphoma
This study is testing a new treatment called MT-601 to see if it can help people with relapsed or hard-to-treat lymphoma feel better.
-
Combination treatment for relapsed B-cell lymphoma
This study is testing a new combination of treatments for people with relapsed B-cell lymphoma to see if it helps them respond better and live longer.
-
New treatment approach for relapsed or refractory Hodgkin lymphoma
This study is testing a new treatment for people with relapsed or hard-to-treat Hodgkin lymphoma to see if combining certain therapies can help them live longer and feel better.
-
Survey of Brentuximab Vedotin for treating pediatric Hodgkin Lymphoma
This study looks at how well Brentuximab Vedotin works with standard treatment for kids with Hodgkin lymphoma and checks for any side effects they might have.
-
Using Tagraxofusp to treat pediatric patients with relapsed or refractory blood cancers
This study is testing a new drug called Tagraxofusp to see if it can help children and young adults with tough-to-treat blood cancers feel better and improve their chances of recovery.
-
Combining targeted immunotherapy with chemotherapy for pediatric lymphoma
This study is testing if adding a new type of immunotherapy to lower doses of chemotherapy can help children and young adults with certain types of lymphoma while keeping them safe.
-
Comparing new drugs to standard treatment for relapsed Hodgkin lymphoma
This study is testing if new drugs Pembrolizumab and Brentuximab vedotin work better than standard treatment for people with relapsed Hodgkin lymphoma.
-
Evaluating Brentuximab Vedotin for Adults with Hodgkin's Lymphoma
This study is testing how well Brentuximab Vedotin works and how safe it is for adults with Hodgkin's Lymphoma who are getting or preparing for a stem cell transplant.
-
Using engineered immune cells with chemotherapy to treat blood cancers
This study is testing if using special immune cells along with chemotherapy can help people with tough-to-treat blood cancers like B-cell lymphoma and leukemia feel better.
-
Investigating early ageing in young cancer patients during treatment
This study is trying to see how cancer treatment affects early aging and heart health in young adults aged 18-39 who are undergoing therapy for cancer.
-
Reduced-intensity conditioning to lower treatment-related mortality in stem cell transplant patients
This study is testing a new way to prepare patients for a stem cell transplant to see if it can lower the risk of serious treatment-related complications.
-
Fecal Microbiota Transplantation to Prevent Complications After Stem Cell Transplantation
This study is testing whether giving a special stool treatment can help prevent complications like Graft-versus-Host Disease in patients receiving stem cell transplants for blood cancers.
-
Comparing T Cell Depletion Methods for Blood Cancer Treatment
This study is testing different ways to prevent complications after a stem cell transplant for blood cancer to see which method helps patients stay healthy and cancer-free longer.
-
Brentuximab vedotin for early stage Hodgkin lymphoma treatment
This study is testing if adding a new drug called brentuximab vedotin to standard chemotherapy can help people with early-stage Hodgkin lymphoma do better in their treatment.
-
Using stem cell transplant and Polatuzumab Vedotin for treating B-cell lymphomas
This study is testing if a stem cell transplant followed by a new drug called Polatuzumab Vedotin can help people with different types of B-cell lymphomas feel better.
-
Donor stem cell transplant with chemotherapy and radiation for blood cancers
This study is testing if a donor stem cell transplant combined with different doses of chemotherapy and radiation can help people with blood cancers recover better.
-
Stem cell transplantation for blood disorders using specific cell depletion techniques
This study is testing a new way of using stem cell transplants for children and young adults with blood disorders to see if removing certain cells helps them recover better and improve their quality of life.
-
Comparing two conditioning regimens for allogeneic hematopoietic cell transplantation
This study is testing two different treatment plans for patients with blood cancers who are getting stem cell transplants from matched donors to see which one helps them stay healthy longer.
-
Combining nivolumab and ruxolitinib for treating relapsed Hodgkin lymphoma
This study is testing if combining two drugs, nivolumab and ruxolitinib, can safely help people with relapsed Hodgkin lymphoma feel better.
-
Testing pembrolizumab with GVD for relapsed Hodgkin lymphoma
This study is testing if combining the immunotherapy drug pembrolizumab with GVD can help people with relapsed Hodgkin lymphoma feel better after their previous treatments.
-
Registry for patients with lymphoid cancers
This study is collecting information from patients with Hodgkin lymphoma, non-Hodgkin lymphoma, and myeloma to better understand their conditions and improve treatment options.
-
Auto stem cell transplant for lymphoma patients
This study tests if a stem cell transplant after chemotherapy can help people with Hodgkin and non-Hodgkin lymphomas, including those with HIV, who are in remission.
-
Investigating genetic factors in childhood cancer
This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.
-
Transplantation with modified stem cells and Zoledronate for pediatric cancers
This study is testing a new way to use modified stem cells and a drug called Zoledronate to see if it can safely help children with tough-to-treat cancers.
-
Access and distribution of unlicensed cryopreserved cord blood units
This study is testing how well unlicensed frozen cord blood units work for helping both kids and adults with blood cancers recover after a transplant.
NIH-funded research (31)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
Understanding why Black and Hispanic Hodgkin lymphoma patients have worse survival
A patient-centered study to uncover social and care factors that contribute to lower survival among Black and Hispanic people with Hodgkin lymphoma across all ages.
-
Novel combination therapy for non-Hodgkin lymphoma in people and dogs
A new treatment combo using an oncolytic virus and other therapies is being tested to help people with hard-to-treat non-Hodgkin lymphoma, with studies also involving dogs to better understand responses.
-
Trajectories of Neurotoxicity in young Hodgkin lymphoma patients
Aging Hodgkin lymphoma patients who are adolescents or young adults may face long-lasting brain and nerve-related side effects from their cancer treatment, and this study aims to map how those problems develop over time.
-
Combination therapy approach for non-Hodgkin lymphoma (NHL)
A Mayo Clinic team is testing a new combination treatment for non-Hodgkin lymphoma to improve responses in patients and in dogs with similar disease.
-
Multi-antigen T cell therapy for relapsed NHL
A patient-derived T cell therapy called MT-601 targets six tumor-associated antigens to help treat relapsed non-Hodgkin lymphoma after other therapies may have failed.
-
Personalized de‑intensification of therapy for NLP Hodgkin lymphoma
A clinician-scientist at Stanford is developing a patient-centered program to tailor and reduce therapy for nodular lymphocyte-predominant Hodgkin lymphoma using tumor and blood samples.
-
Combining international Hodgkin lymphoma data to understand long-term treatment effects
This project brings together trial and registry data to learn how treatments affect long-term health in adults with Hodgkin lymphoma.
-
Precision targeted radioactive antibody therapy for non-Hodgkin lymphoma
Researchers are developing more precise radioactive antibodies to treat people with CD20-positive non-Hodgkin lymphoma.
-
AI-designed drugs targeting a common lymphoma mutation (MYD88 L265P)
Researchers are using artificial intelligence to create and test new drugs that block a common MYD88 mutation found in many B‑cell non‑Hodgkin lymphomas to help people with these cancers.
-
New combination therapy for non-Hodgkin lymphoma
A virus-based combination treatment aims to boost the immune system to help people and companion dogs with relapsed or treatment-resistant diffuse large B-cell lymphoma.
-
New combination treatment for diffuse large B‑cell lymphoma
This project is trying a virus-based therapy together with checkpoint immunotherapy for people (and companion dogs) with relapsed diffuse large B‑cell lymphoma.
-
MT-601 T Cell Therapy for Relapsed Non-Hodgkin Lymphoma
This opportunity explores a new T cell therapy called MT-601 for people with Non-Hodgkin Lymphoma that has returned after previous treatments.
-
New antibody treatment for Non-Hodgkin Lymphoma and a type of skin lymphoma
This project is testing a new antibody treatment, called BITR2101, for people with certain types of cancer, including Non-Hodgkin Lymphoma and Cutaneous T Cell Lymphoma.
-
Understanding how Hodgkin lymphoma cells evade the immune system
This study is looking at how Hodgkin lymphoma cells manage to hide from the immune system and keep growing, focusing on a specific protein complex, and it aims to find new ways to improve treatments for patients dealing with advanced or returning cases of this cancer.
-
New targeted treatments for non-Hodgkin lymphoma
This study is working on new treatments for non-Hodgkin lymphoma using advanced antibodies that could be more effective and safer, with the hope of offering better options for patients like you.
-
Understanding genetic factors that affect treatment success in Hodgkin lymphoma
This study is looking at how certain genetic changes and bits of tumor DNA in your blood can help doctors figure out the best treatment for people with classical Hodgkin lymphoma, aiming to create personalized plans that reduce the side effects of chemotherapy.
-
Understanding the long-term effects of treatment in Hodgkin lymphoma patients
This study is looking at how treatments for Hodgkin lymphoma might affect your health in the long run, especially regarding risks for other cancers and heart problems, using information from over 12,000 patients to help understand these effects better.
-
Combining therapies to improve treatment for non-Hodgkin lymphoma
This study is looking at a new treatment for diffuse large B-cell lymphoma, the most common type of non-Hodgkin lymphoma, to find out how to make current therapies work better, and it involves comparing cases in people and dogs to learn more about how to fight this cancer effectively.
-
Understanding why Black and Hispanic patients with Hodgkin lymphoma have lower survival rates
This study is looking into why Black and Hispanic patients with Hodgkin lymphoma have lower survival rates, and it aims to find out what challenges they face so that we can create better support and treatment options for them.
-
Investigating heart and brain function in survivors of Hodgkin Lymphoma
This study is looking at how treatments for Hodgkin Lymphoma might impact heart and lung health, and how that could affect brain function in survivors, so if you're a survivor, we’d love for you to join us to help understand these connections better!
-
Targeting a key driver of Non-Hodgkin Lymphoma using artificial intelligence
This study is using smart computer technology to find new ways to create medicines that can help people with Non-Hodgkin Lymphoma by targeting specific proteins that are hard to treat, especially those linked to a common gene mutation.
-
Investigating how HIV affects the development of classic Hodgkin lymphoma
This study is looking at why people with HIV might have a higher chance of developing classic Hodgkin lymphoma, and it aims to understand the differences in their immune system and genes that could lead to this cancer, with the help of patient samples.
-
Personalized treatment approaches for a rare type of Hodgkin lymphoma
This study is looking to create personalized treatment plans for people with nodular lymphocyte-predominant Hodgkin lymphoma by examining their tumor and blood samples to find out which therapies might work best for them, helping to reduce side effects while still being effective.
-
New T cell therapy for patients with relapsed Non-Hodgkin Lymphoma
This study is testing a new treatment for people with relapsed Non-Hodgkin Lymphoma that uses their own immune cells to better fight cancer by targeting multiple markers on the cancer cells, with the hope of making the treatment more effective and lowering the risk of the cancer coming back.
-
New combination therapy for non-Hodgkin lymphoma
This study is looking at a new treatment approach for people with diffuse large B-cell lymphoma (DLBCL), a common type of cancer, to help improve how well therapies work, especially for those with advanced cases, by learning from both human and dog cases.
-
New treatment targeting cancer cells and their supportive environment in Non-Hodgkin Lymphoma.
This study is testing a new treatment called BITR2101 that targets a specific part of cancer cells to help stop the growth of Non-Hodgkin Lymphoma, especially for those with Cutaneous T Cell Lymphoma, and it may be used on its own or with other therapies to improve patient outcomes.
-
Investigating the genetics of Hodgkin lymphoma that doesn't respond to treatment
This study is looking at the genetic changes in Hodgkin lymphoma to find out why some patients don’t respond to standard treatments or have relapses, with the hope of discovering better treatment options for those who need them.
-
Investigating aging-related biomarkers in long-term survivors of Hodgkin lymphoma
This study is looking at how aging affects brain health in long-term survivors of Hodgkin lymphoma who didn't receive certain brain-targeting treatments, with the hope of finding clues that could help improve their memory and thinking skills.
-
Improving CAR T cell therapy for Hodgkin Lymphoma
This study is testing a new treatment for people with Hodgkin Lymphoma that uses specially modified immune cells to better find and attack cancer cells, and it's designed for those whose cancer has come back or hasn't responded to other treatments.
-
Investigating Hodgkin lymphoma in people living with HIV in South Africa
This study is looking at how Hodgkin lymphoma affects people living with HIV in South Africa, comparing their experiences with those who don’t have HIV, to better understand how factors like organ health and other infections might influence treatment and outcomes.
-
Finding ways to identify when non-Hodgkin lymphoma comes back using electronic health records.
This study is working on new ways to use health records to better spot when non-Hodgkin lymphoma comes back, especially for those with diffuse large B-cell lymphoma or follicular lymphoma, so that patients can get better care and monitoring.
Related topics
Quick answers
How many Hodgkin Lymphoma clinical trials are recruiting right now?
64, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 27 countries. The most sites are in United States (38 trials), Italy (6 trials), Australia (5 trials), China (4 trials), Russia (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 24, Phase 1: 10, Phase 1/2: 6, Phase 3: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.