Antibiotics versus immunoglobulin to prevent infections in people with blood cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This domain of an adaptive platform compares prophylactic antibiotics with ongoing intravenous immunoglobulin (IVIg) replacement to prevent bacterial infections in patients with blood cancers. The platform design lets researchers run multiple comparisons at once, adapt allocations based on incoming results, and add new questions during the trial. Participants are those already receiving standard-dose IVIg for at least six months who are not considered suitable to stop Ig by their treating clinician. Key outcomes include infection rates, safety, and healthcare use such as hospital admissions and antibiotic courses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients must be receiving IVIg replacement at standard dose for prevention of bacterial infections due to hypogammaglobulinaemia for at least 6 consecutive months.
2. Patient is not eligible for trial of Ig cessation in the opinion of the treating clinician and local investigator.

Exclusion Criteria:

1. Prior or planned allogeneic haematopoietic stem cell transplantation.
2. Major infection (Grade 3 or higher) in preceding 3 months, and or current active infection requiring systemic antimicrobial treatment.
3. Previous splenectomy.
4. Known history of bronchiectasis.
5. Previous participation in this domain.
6. Treating team deems enrolment in the domain is not in the best interest of the patient.

Where it's running

• Royal Adelaide Hospital
  Adelaide, South Australia, Australia Recruiting
• Austin Hospital
  Melbourne, Victoria, Australia Recruiting
• Northern Health
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Principal investigator: Zoe McQuilten, Professor — Monash University

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Stopping immunoglobulin replacement with or without antibiotics to prevent infections in blood cancer patients

  This trial tests if stopping immunoglobulin replacement, with or without daily preventive antibiotics, is safe and keeps infections low in people with myeloma, leukemia, or non-Hodgkin's lymphoma who have been on Ig therapy.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202091

• Preventing infections in people with blood cancers using antibiotics or immunoglobulin

  This project tests whether giving regular intravenous immunoglobulin or prophylactic antibiotics better prevents infections in people with myeloma, non-Hodgkin lymphoma, or leukemia who have not yet started immunoglobulin replacement.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202078

• Chemotherapy-related thinking and memory changes during treatment for blood cancers

  This project will follow adults with acute myeloid leukemia, Hodgkin's lymphoma, or non-Hodgkin's lymphoma who are receiving first-line fixed-duration chemotherapy to see how common and how severe chemotherapy-related thinking and memory problems are compared with a close relative.

  Recruiting University Hospital, Angers · Angers, Maine et Loire · NCT07147621

• Genetics of Blood Cancers in the U.S. population

  This study tests how genetic factors relate to blood cancers by collecting saliva DNA and online health surveys from at least 10,000 U.S. adults.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07714044

• Comparing antibiotics and immunoglobulin to prevent infections in blood cancers

  This project tests whether immunoglobulin or antibiotic strategies better prevent infections in adults with blood cancers.

  Recruiting at 3 sites Phase 2/3 Monash University · Adelaide, South Australia and 2 other locations · NCT07202052

• Telehealth music therapy for cognitive difficulties in blood cancer survivors

  This program will test whether telehealth music therapy can help adults who survived leukemia, lymphoma, or myeloma and who are having trouble with memory, attention, or thinking.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07052916

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.