Using a NEWS early warning score to prompt ICU admission for adults receiving intensive chemotherapy or stem cell transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this interventional study, clinical teams calculate the National Early Warning Score (NEWS) in real time for adults hospitalized in protected hematology units for induction therapy of acute leukemias or for intensive chemotherapy with autologous or allogeneic hematopoietic cell transplantation. The protocol calls for prompt ICU admission when a patient’s NEWS reaches or exceeds 7 to allow earlier organ-specific interventions and closer monitoring. Outcomes such as survival, timing of organ support, ICU use, and patient-centered effects will be compared between the NEWS-driven pathway and usual monitoring. The study also monitors for potential downsides, including increased ICU resource use and patient anxiety resulting from earlier transfers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient
* Hospitalization in a protected unit of a hematology department for induction therapy of acute myeloid leukemia or acute lymphoblastic leukemia induction, intensive chemotherapy with autologous hematopoietic cell transplantation, allogeneic hematopoietic cell transplantation
* Expected length of stay in the hematology department of at least 7 days
* Patient with social security
* Signed informed consent form

Exclusion Criteria:

* Decision of care limitation with decision not to transfer to ICU or not initiate organ support
* Pregnant, parturient or breastfeeding woman
* Person deprived of liberty by judicial or administrative decision
* Person under forced psychiatric care
* Person under legal protection
* Person unable to express consent
* Hospitalization for Chimeric Antigenic Receptor (CAR) T-cell therapy

Where it's running

• Centre Hospitalier Amiens-Picardie
  Amiens, France Recruiting
• Centre Hospitalier Universitaire d'Angers
  Angers, France Recruiting
• Centre Hospitalier Universitaire Besancon
  Besançon, France Recruiting
• Centre Hospitalier Universitaire Brest
  Brest, France Recruiting
• Centre Hospitalier universitaire Nancy
  Nancy, France Recruiting
• Centre Hospitalier Universitaire Nantes
  Nantes, France Recruiting

Study contacts

• Study coordinator: Corentin Orvain, MD PhD
• Email: Corentin.Orvain@chu-angers.fr
• Phone: 02 41 35 36 37

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.