Condition

Hematologic Malignancy clinical trials and research

• 62Clinical trials
• 3NIH research projects
• 1New in 30 days
• 18Countries

Newest Hematologic Malignancy clinical trials

All recruiting trials (62)

• High-dose vs standard-dose flu vaccine in adults with blood cancers on B-cell-depleting therapy

  This study tests whether a high-dose flu shot evokes a stronger immune response than a standard-dose shot in adults with hematologic cancers who recently had B-cell-depleting therapy.

  Recruiting Phase 2 Asan Medical Center · Seoul · NCT07926217

• CD45RA-depleted donor cells to help fight stubborn viral infections after haploidentical transplant

  This trial tests whether giving patients specially prepared donor immune cells (CD45RA-depleted DLI) can help clear viral infections that linger after a stem cell transplant and who have not fully recovered their immunity.

  Recruiting Phase 1/2 Ruijin Hospital · Shanghai, SH · NCT07662369

• Identifying biomarkers for CAR-T cell therapy in cancer patients

  This study looks at real-world CAR-T therapy in adults with blood cancers to see which biomarkers predict who responds or relapses.

  Recruiting University Hospital, Lille · Lille and 1 other locations · NCT07609485

• QH101 Vδ2 T-cell therapy for adults with relapsed or advanced malignant tumors

  This study will try QH101, an off-the-shelf Vδ2 T-cell therapy, in adults with relapsed or advanced blood cancers or solid tumors to see if it is safe and helps fight tumors.

  Recruiting Phase 1/2 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07570563

• Short versus long maribavir treatment after allogeneic stem cell transplant

  This trial tests whether a shorter or longer course of maribavir helps adults with refractory CMV infection after their first allogeneic stem cell transplant.

  Recruiting Phase 3 Ruijin Hospital · Shanghai · NCT07511127

• Seeing if DCog Short on an iPad can spot neurotoxicity in CAR-T patients

  This study tests whether a self-report iPad tool called DCog Short can help identify neurotoxicity in people receiving CAR-T cell therapy.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT07403812

• Preventing G-CSF bone pain with diosmin-hesperidin and loratadine

  We will test whether diosmin-hesperidin, loratadine, or both can prevent bone pain from G-CSF in adults with leukemia or lymphoma.

  Recruiting Alexandria University · Alexandria · NCT07300735

• CD19‑CAR T‑cell consolidation after TCRαβ/CD19‑depleted haploidentical family donor transplant for relapsed/refractory CD19+ B‑cell leukemia and lymphoma

  This will try giving CD19‑targeted CAR T cells shortly after a partially matched family‑donor transplant to children and young adults (≤21) with relapsed or refractory CD19+ B‑cell leukemia or lymphoma to see if the approach is safe and feasible.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07257419

• Virtual reality headsets to reduce pain and anxiety during bone marrow biopsy

  This will try a virtual reality headset to see if it reduces pain and anxiety for adults having an outpatient bone marrow biopsy or aspiration.

  Recruiting Wake Forest University Health Sciences · Charlotte, North Carolina · NCT07203534

• How cancer and immune cell metabolism shape blood cancers and treatment response

  This project sees if the metabolism of cancer and immune cells in the bone marrow affects treatment outcomes for adults with blood cancers such as AML, MDS, ALL, and myelofibrosis.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT07189117

• Remove incorrect beta-lactam (penicillin and cephalosporin) allergy labels to expand antibiotic options for patients with blood cancers.

  This project tests a pharmacist-led process to remove incorrect penicillin or other beta-lactam allergy labels in hospitalized patients with blood cancers so they can receive preferred antibiotics and potentially have better outcomes.

  Recruiting Phase 4 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07133074

• Blood transfusions at home

  This pilot tests whether giving required blood transfusions at home works well and is acceptable for adults with transfusion-dependent blood cancers or bone marrow failure who receive care at SKCCC.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07121140

• TCRαβ‑depleted haploidentical stem cell graft with early memory T‑cell donor lymphocyte infusions and selective blinatumomab for pediatric and young adult blood cancers

  This will test whether giving a TCRαβ‑depleted haploidentical stem cell graft plus early CD45RA‑depleted memory T‑cell infusions, with selective use of blinatumomab for CD19+ disease, is safe for children and young adults undergoing transplant for high‑risk blood cancers.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07052370

• Adding decitabine and venetoclax to fludarabine/melphalan reduced‑intensity transplant for myeloid cancers

  This study tests whether giving decitabine and venetoclax around a reduced‑intensity allogeneic transplant is safe for adults with high‑risk acute myeloid leukemia or myelodysplastic syndromes.

  Recruiting Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT07044544

• T-cell developmental status in people with blood cancers

  This project will see if tracking T-cell development and immune markers before and after treatment can help guide care for adults with B-cell lymphoma or multiple myeloma.

  Recruiting The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT07035938

• WBC100 capsules for adults with relapsed or refractory acute myeloid leukemia

  This trial will test whether taking WBC100 capsules once daily is safe and can help induce remission in adults with relapsed or refractory acute myeloid leukemia.

  Recruiting Phase 1 Hangzhou Weben Pharma Co., Ltd · Hangzhou, Zhejiang · NCT07014449

• Belumosudil to prevent graft-versus-host disease after a stem cell transplant

  This will test whether adding the drug belumosudil to standard prevention lowers the risk of graft-versus-host disease in adults with blood cancers after a stem cell transplant.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT07006506

• Pharmacist-led program to help patients take oral cancer medicines as prescribed

  This program will test whether pharmacist counseling and risk-based monitoring helps adults with solid tumors or blood cancers who have been on oral cancer medicines for at least six months take their medication more consistently.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06989489

• Improving outcomes for stem cell transplant patients using an intervention website

  This study is testing if a special website can help adults with blood cancer feel better and improve their quality of life after a stem cell transplant compared to a regular educational website.

  Recruiting at 3 sites Northwestern University · Washington D.C., District of Columbia and 2 other locations · NCT06960993

• Best germline DNA source to guide drug dosing after allogeneic stem cell transplant

  This project will test whether blood, skin, or other tissue samples give the most reliable genetic information to guide medicine dosing for adults who receive an allogeneic stem cell transplant.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06856226

• Abatacept to prevent GVHD after omidubicel cord-blood transplant

  This trial tests whether adding abatacept with tacrolimus and mycophenolate can prevent graft-versus-host disease in adults receiving omidubicel cord-blood stem cell transplants for blood cancers.

  Recruiting Early Phase 1 Duke University · Durham, North Carolina · NCT06731504

• Treatment of CD7-positive blood cancers using CAR-T cells

  This study is testing a new CAR-T cell therapy designed to target CD7 in patients with certain blood cancers that haven't responded to other treatments.

  Recruiting Phase 1/2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06720324

• A tool to improve family communication in pediatric stem cell transplant decisions

  This study is testing a new tool to help families talk better and make decisions together about stem cell transplants for kids aged 8 to 17.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06689800

• Primary palliative care for people undergoing stem cell transplant

  We will try training transplant clinicians to provide basic palliative care during hospital stays to see if it works and is acceptable for adults having stem cell transplants.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06676852

• Evaluating the delayed effects of CAR T cell therapy in children

  This study looks at the short-term and long-term side effects of CAR T cell therapy in children with certain types of cancer to see how it affects them over time.

  Recruiting at 7 sites St. Jude Children's Research Hospital · Los Angeles, California and 6 other locations · NCT06579469

• Using Posaconazole to Prevent Fungal Infections in High-Risk Stem Cell Transplant Patients

  This study is testing if Posaconazole can help prevent serious fungal infections in patients who are at high risk after receiving a stem cell transplant.

  Recruiting Phase 2 Nantes University Hospital · Nantes, France · NCT06541067

• Mindfulness program to improve sleep and symptoms during and after hospital treatment for blood cancers

  This study will test a mindfulness-based mobile app during hospitalization plus six follow-up video therapy sessions to help adults with hematologic cancers sleep better and manage fatigue, pain, and stress.

  Recruiting Duke University · Durham, North Carolina · NCT06532773

• Home blood transfusions for people with advanced blood cancers in hospice

  The study will test whether offering home blood transfusions to adults with advanced or relapsed blood cancers who are eligible for hospice helps improve quality of life, mood, and end-of-life care.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06487247

• Testing TGRX-1942 for advanced solid tumors and blood cancers

  This study is testing a new treatment called TGRX-1942 to see if it can safely help people with advanced solid tumors and certain blood cancers.

  Recruiting Phase 1 Shenzhen TargetRx Co., Ltd. · Hangzhou, Zhejiang · NCT06484816

• Psychosocial support for caregivers of bone marrow transplant patients

  This study is testing a new support program for caregivers of bone marrow transplant patients to see if it can help them feel better and cope with stress during the recovery process.

  Recruiting at 3 sites Massachusetts General Hospital · Birmingham, Alabama and 2 other locations · NCT06472089

• Preventing GvHD in patients with blood cancers undergoing stem cell transplants

  This study is testing a new treatment called TRX-103 to see if it can help prevent graft-versus-host disease in people with blood cancers who are getting stem cell transplants from mismatched donors.

  Recruiting at 5 sites Phase 1 Tr1X, Inc. · Duarte, California and 4 other locations · NCT06462365

• Evaluating the role of genetics in kidney disease progression

  This study is trying to see how genetics affects the worsening of kidney diseases like acute kidney injury and chronic kidney disease in people, especially those with high blood pressure.

  Recruiting Ospedale San Raffaele · Milan · NCT06416761

• Continued treatment with pelabresib for patients from previous studies

  This study is testing whether continued treatment with pelabresib can help people who have already tried it in earlier studies stay healthy and live longer without leukemia.

  Recruiting at 15 sites Phase 3 Novartis · Los Angeles, California and 14 other locations · NCT06401356

• Using Darzalex Faspro to lower antibody levels before stem cell transplant

  This study is testing if a new treatment called Darzalex Faspro can help lower harmful antibodies in adults so they can safely receive a stem cell transplant for blood cancers.

  Recruiting Early Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06398457

• Early heart function check after CAR-T treatment

  We will test whether people treated with CAR‑T cells for blood cancers have early changes in heart function by doing an ultrasound and blood tests 3–5 days after infusion.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06350994

• CAR T-cell therapy for children with hard-to-treat blood cancers

  This study is testing a new CAR T-cell therapy to see if it can safely help children and young adults with tough-to-treat blood cancers like leukemia and lymphoma.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06326463

• Testing a new approach to prevent graft-versus-host disease after stem cell transplantation

  This study is testing a new treatment to see if a combination of two drugs can help prevent graft-versus-host disease in patients receiving stem cell transplants, allowing them to stop taking immunosuppressive drugs sooner.

  Recruiting at 3 sites Phase 2 Nantes University Hospital · Angers and 2 other locations · NCT06252870

• Evaluating TGRX-814 in patients with blood cancers

  This study is testing a new drug called TGRX-814 to see if it is safe and effective for people with blood cancers like lymphoma and leukemia.

  Recruiting Phase 1/2 Shenzhen TargetRx Co., Ltd. · Tianjin, Tianjin Municipality · NCT06206174

• Study of crushed venetoclax tablets dissolved in liquid for pediatric patients

  This study tests if crushing venetoclax tablets and mixing them with liquid helps children with blood cancers absorb the medication better and stay safe while taking it.

  Recruiting at 5 sites Children's Hospital Medical Center, Cincinnati · Aurora, Colorado and 5 other locations · NCT06131801

• Assessing immune profiles to predict responses to cancer immunotherapy

  This study is testing if certain immune profiles can help predict how well cancer patients will respond to approved immunotherapy treatments.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06116032

• Depletion of specific immune cells for stem cell transplantation in young patients

  This study is testing a new way to prepare stem cells for children and young adults with blood cancers by removing certain immune cells to see if it helps them have a safer and more effective transplant from unrelated donors.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06082947

• Examining the safety of ziftomenib combinations for patients with relapsed acute myeloid leukemia

  This study is testing if combining ziftomenib with standard treatments can safely help people with relapsed acute myeloid leukemia feel better and improve their chances of recovery.

  Recruiting at 43 sites Phase 1 Kura Oncology, Inc. · Gilbert, Arizona and 44 other locations · NCT06001788

• Infusion of modified donor immune cells after stem cell transplant for blood cancers

  This study is testing a new way to use modified immune cells after a stem cell transplant to see if it helps people with blood cancers without causing serious side effects.

  Recruiting at 2 sites Phase 1/2 University Hospital Tuebingen · Tübingen and 1 other locations · NCT05943067

• Combining stem cell collection with CAR T-cell therapy for blood cancers

  This study is testing if collecting stem cells from patients with blood cancers can safely be combined with CAR T-cell therapy to improve treatment outcomes.

  Recruiting Phase 1 Cedars-Sinai Medical Center · Los Angeles, California · NCT05887167

• Validation of the OHI Index for Hematologic Malignancies

  This study is testing a new index to see if it can help doctors better understand and predict outcomes for patients with blood cancers who might develop a serious condition called HLH.

  Recruiting at 2 sites Meir Medical Center · Kfar Saba and 1 other locations · NCT05882175

• Cold versus room-temperature platelet storage for treating bleeding in hematologic malignancy

  This pilot will test whether cold-stored platelets stop bleeding better than room-temperature platelets in adults with hematologic cancers or marrow aplasia who need a platelet transfusion.

  Recruiting Phase 2 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05820126

• Molecular-genetic analysis in patients receiving CAR-T cell therapy

  This study is testing how well a new type of cancer treatment using specially modified immune cells can help patients with blood cancers.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Italy · NCT05807789

• T cell receptor depletion for blood cancer treatment

  This study is testing a new way to treat blood cancers by using a special treatment before a stem cell transplant to see if it helps both kids and adults do better after the procedure.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05735717

• Early detection and screening for blood cancers

  This study is testing if analyzing blood samples can help spot early signs of blood cancers like multiple myeloma and lymphoma in patients.

  Recruiting at 4 sites JaxBio Ltd · Olomouc and 3 other locations · NCT05735704

• Combining a ketogenic diet with cognitive training for blood cancer survivors

  This study is testing if a special diet combined with online brain training can help blood cancer survivors think better over 12 weeks.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05708716

• Improving quality of life for blood cancer patients receiving cellular therapy

  This study is testing a new palliative care program called PEACE to see if it can improve the quality of life for blood cancer patients getting cellular therapy.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05646576

• Global Cardio Oncology Registry

  This study is collecting health information from cancer patients around the world to see what factors might increase their risk of heart problems caused by cancer treatments.

  Recruiting The Cleveland Clinic · Weston, Florida · NCT05598879

• Combining pirtobrutinib and venetoclax for treating relapsed mantle cell lymphoma

  This study is testing if combining two medications, pirtobrutinib and venetoclax, can help people with relapsed mantle cell lymphoma feel better and improve their chances of survival.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05529069

• Using Tagraxofusp to treat pediatric patients with relapsed or refractory blood cancers

  This study is testing a new drug called Tagraxofusp to see if it can help children and young adults with tough-to-treat blood cancers feel better and improve their chances of recovery.

  Recruiting at 15 sites Phase 1 Therapeutic Advances in Childhood Leukemia Consortium · Los Angeles, California and 30 other locations · NCT05476770

• Collecting data to predict cancer risk in at-risk populations

  This study is trying to collect samples and health information from people at higher risk of cancer to see if they can find signs that help predict cancer early on.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT05463796

• Reduced intensity transplant protocol for hematologic malignancies

  This study is testing a gentler transplant method using a specific combination of medications and radiation to see if it helps patients with blood cancers who have a matched donor.

  Recruiting Northside Hospital, Inc. · Atlanta, Georgia · NCT05417971

• Evaluating how pediatric cancer patients respond to the flu vaccine

  This study is testing how well the flu vaccine works in children with cancer to see if it helps them build immunity against the virus.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05384288

• Prophylactic treatment using donor lymphocytes after haploidentical stem cell transplantation

  This study is testing if giving special donor immune cells to patients after a specific type of stem cell transplant can help prevent complications safely.

  Recruiting Phase 1 University Hospital, Geneva · Geneva, Canton of Geneva · NCT05066412

• Improving diagnosis of hematological diseases using advanced sequencing techniques

  This study is testing new genetic sequencing methods to help doctors better diagnose blood disorders in patients who currently have unclear or unusual symptoms.

  Recruiting Munich Leukemia Laboratory · Munich · NCT05046444

• Using Human T Lymphoid Progenitor Injection to Boost Immune Recovery After Cord Blood Transplant

  This study is testing if injections of a special type of immune cell can help adults with blood cancers recover their immune system faster after receiving a cord blood transplant.

  Recruiting at 4 sites Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris and 4 other locations · NCT04707300

• Improving leukemia diagnosis using artificial intelligence

  This study is testing whether an artificial intelligence system can improve the diagnosis of leukemia by comparing its accuracy and speed to traditional methods using a large set of blood samples.

  Recruiting Munich Leukemia Laboratory · Munich, Bavaria · NCT04466059

• Cohort study of patients with blood cancers in Languedoc-Roussillon

  This study is tracking adults with blood cancers like lymphoma and leukemia to see how these diseases develop over time and improve future treatments.

  Recruiting University Hospital, Montpellier · Montpellier · NCT02134574

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Safer antibiotic choices for people with blood cancers and reported penicillin/beta‑lactam allergy

  This project helps people with blood cancers who report a penicillin or related antibiotic allergy learn whether they can safely use those drugs so they can get the most effective antibiotics.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11261247

• Improving antibiotic choices for cancer patients with reported penicillin allergies

  This study is looking to help patients with blood cancers who are at risk for infections by finding better ways to choose antibiotics, especially for those who might have been wrongly labeled as allergic to certain medications, so they can receive safer and more effective treatments.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11077256

• How early gut bacteria affect the risk of fever and infections in blood cancer patients

  This study is looking at how the bacteria in your gut might affect your chances of getting fevers and infections while you're being treated for blood cancers, so we can tailor antibiotic treatments just for you and help you feel better faster.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10765642

Related topics

Quick answers

How many Hematologic Malignancy clinical trials are recruiting right now?

62, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (36 trials), China (8 trials), France (6 trials), Italy (4 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 11, Phase 2: 7, Phase 1/2: 6, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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