Condition

Kidney Disease clinical trials and research

• 29Clinical trials
• 403NIH research projects
• 32Countries

Newest Kidney Disease clinical trials

All recruiting trials (29)

• Pedal Pump Device for Lower Extremity Edema in Hospitalized Patients

  This study tests a foot-pump device to see if it is tolerable and can help reduce swelling in the legs of hospitalized patients with edema.

  Recruiting Hillcrest · Tulsa, Oklahoma · NCT07760363

• Adapting and testing PEN-Plus in Zambian primary care

  Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.

  Recruiting Centre for Infectious Disease Research in Zambia · Lusaka, Lusaka Province · NCT07753681

• Effects of general vs spinal-epidural anesthesia on kidney transplant biomarkers

  This study tests whether sevoflurane general anesthesia or combined spinal-epidural anesthesia changes markers of cellular stress and protective peptides in adults undergoing kidney transplantation.

  Recruiting University of Gaziantep · Gaziantep, State/Province · NCT07678073

• Impact of a Clinical Information System on hospital outcomes for adults with chronic diseases

  This study tests whether implementing a Clinical Information System helps reduce readmissions or death within 30 days after hospital discharge for adults with chronic conditions in Alberta.

  Recruiting University of Calgary · Calgary, Alberta · NCT07609381

• GSK4771261 in Healthy Adults Aged 25–55 in Asia and Europe

  This study tests whether GSK4771261 is safe and how it behaves in the body of healthy adults to see if it could be used safely in the future.

  Recruiting Phase 1 GlaxoSmithKline · Groningen · NCT07600450

• Red propolis supplementation for people with chronic kidney disease

  This study tests whether taking red propolis daily for 8 weeks can reduce inflammation and oxidative stress in people with chronic kidney disease who are managed without dialysis.

  Recruiting Universidade Federal Fluminense · Rio de Janeiro, Rio de Janeiro · NCT07597005

• AdiaVita regenerative therapy for chronic kidney disease

  This trial tests whether AdiaVita (umbilical cord blood stem cells and exosomes plus glutathione) can improve kidney function in adults with stage 2–4 chronic kidney disease.

  Recruiting Phase 1 Adia Med of Winter Park LLC · Winter Park, Florida · NCT07572890

• Kidney and liver blood flow patterns after major trauma

  We will use bedside ultrasound to see whether abnormal kidney and liver blood flow patterns occur in adults admitted to the ICU after major trauma and whether those patterns link to acute kidney injury or the need for mechanical ventilation.

  Recruiting Azienda Usl di Bologna · Bologna · NCT07492511

• Digital support to reduce salt intake for people with type 2 diabetes and kidney disease

  This project will test whether a smartphone app can help people with type 2 diabetes and moderately reduced kidney function eat less salt and follow kidney-friendly protein guidance over six months.

  Recruiting at 2 sites Steno Diabetes Center Copenhagen · Herlev, Captial Region of Denmark and 1 other locations · NCT07485075

• Cardiovascular, Kidney, and Metabolic Health Assessment with Patient Empowerment

  This program will test whether an AI chatbot, large language model Copilot, and remote vital‑sign monitoring can help adults with diabetes, heart disease, or chronic kidney disease reduce their combined cardio‑kidney‑metabolic disease burden.

  Recruiting at 2 sites Aventyn, Inc. · Chandler, Arizona and 4 other locations · NCT07403669

• Identifying harmful IgA in IgA-related kidney disease

  This project will test whether specific forms of IgA in adults with IgA nephropathy or IgA vasculitis cause kidney damage by analyzing blood and biopsy samples.

  Recruiting University Hospital, Limoges · Limoges · NCT07295808

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Rutgers University Genetics of Kidney Disease

  This project will see if genes are linked to kidney disease risk by collecting health surveys and saliva DNA from people 18 and older in the U.S.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07217535

• Physiologic insulin resensitization for adults with stage 3b–5 chronic kidney disease and type 2 diabetes

  This trial will test whether physiologic insulin resensitization (PIR) helps adults with stage 3b–5 chronic kidney disease and type 2 diabetes do better than standard care.

  Recruiting at 2 sites Well Cell Global · Phoenix, Arizona and 1 other locations · NCT07187479

• Kidney and heart prevention program after preeclampsia

  This program will see if follow-up care plus a biobank can help identify and manage long-term kidney and heart risks for women who had preeclampsia, HELLP, eclampsia, or pregnancy-related kidney disease.

  Recruiting University Hospital Schleswig-Holstein · Kiel · NCT07151339

• Direct-to-patient biospecimen and health data collection

  This project collects biospecimens, health and lifestyle information from adults (including healthy volunteers and people with conditions like lupus, celiac disease, or chronic kidney disease) to connect them with researchers.

  Recruiting Joined Bio · Lexington, Massachusetts · NCT07128966

• Sensor-based congestion alert for people on peritoneal dialysis

  This study tests whether the Bodyport Cardiac Scale can help predict worsening fluid overload events in adults receiving automated peritoneal dialysis.

  Recruiting at 7 sites Bodyport Inc. · Victorville, California and 6 other locations · NCT07059962

• RaDIANT health system changes to speed transplant evaluation

  This study tests whether system-level changes in transplant care can help more people move through evaluation sooner after dialysis referral.

  Recruiting at 5 sites Indiana University · Atlanta, Georgia and 4 other locations · NCT07033117

• Prospective blood collection to detect donor-derived cell-free DNA after kidney transplant

  This project will collect blood from adults who had a kidney transplant to try a blood test that detects donor-derived cell-free DNA to check the transplanted organ.

  Recruiting at 6 sites Devyser Inc. · San Diego, California and 6 other locations · NCT07006831

• Inspire HER: a heart-health and stress-support program for Black women

  This project will test whether the Inspire HER lifestyle program helps Black women with higher heart disease risk improve heart health and manage stress.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06966258

• Mezagitamab for adults with IgA nephropathy

  This trial will test if mezagitamab can reduce protein in the urine of adults with primary IgA nephropathy.

  Recruiting at 186 sites Phase 3 Takeda · Birmingham, Alabama and 185 other locations · NCT06963827

• Investigating the effects of glucose-lowering and immunosuppressive therapies on immune response in diabetes and kidney disease

  This study is testing if new diabetes medications can lower harmful immune responses in people with diabetes and kidney disease to help prevent serious complications.

  Recruiting Western Galilee Hospital-Nahariya · Nahariya · NCT06821919

• Identifying biomarkers in kidney disease before and after transplantation

  This study is trying to find specific markers in urine, blood, and tissue that can help doctors better diagnose and predict kidney disease before and after a transplant.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06810258

• Immunological reset to help highly sensitized kidney transplant candidates receive transplants

  This study is testing a new treatment to help people who have been waiting a long time for a kidney transplant because of high sensitization levels, to see if it can make it easier for them to get a compatible kidney.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona · NCT06809075

• Impact of 177Lu-PSMA therapy on kidney function in prostate cancer patients

  This study is testing how a new prostate cancer treatment affects kidney function in men with advanced prostate cancer over five years.

  Recruiting Technical University of Munich · Munich · NCT06720532

• Dialysis that removes more middle molecules using super high‑flux filters

  This trial will test whether using super high‑flux (expanded) dialysis filters instead of standard high‑flux filters reduces the risk of death and other harms for adults on in‑center hemodialysis who are older or have diabetes.

  Recruiting at 2 sites London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario and 2 other locations · NCT06660277

• Empagliflozin to protect kidney and heart health after heart transplant

  This trial will test whether empagliflozin can protect kidney and heart health and improve metabolic and functional outcomes in Veterans who have had a heart transplant.

  Recruiting Phase 4 VA Office of Research and Development · Palo Alto, California and 5 other locations · NCT06625073

• Maribavir for CMV in adults with kidney failure after transplantation

  This project will see if maribavir is safe for adults with severe kidney failure (including people on dialysis) who develop CMV after a transplant by reviewing existing medical records.

  Recruiting at 9 sites Takeda · Anderlecht, Brussels Capital and 24 other locations · NCT06243731

• Observing kidney diseases related to the immune system

  This study is trying to learn more about kidney diseases caused by the immune system in patients to find better treatments and understand how these conditions develop.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001979

NIH-funded research (newest 40 of 403)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Personalized CKD-MBD care using systems biology and AI

  A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.

  NIH research VA North Texas Health Care System · Dallas, United States · NIH-11644324

• Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors

  This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.

  NIH research Healthpartners Institute · Bloomington, UNITED STATES · NIH-11595907

• Chronic Kidney Disease in Children: following young people as they grow up with CKD

  A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.

  NIH research Children's Mercy Hosp (Kansas City, Mo) · Kansas City, United States · NIH-11588599

• Chronic Kidney Disease in Children follow-up study

  A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.

  NIH research Children's Mercy Hosp (Kansas City, Mo) · Kansas City, United States · NIH-11588598

• KDARC: Building a research backbone to study aging and kidney disease

  Aimed at creating a dedicated infrastructure to advance aging-related kidney disease research so clinicians can better care for older adults.

  NIH research New York University School of Medicine · New York, United States · NIH-11537509

• Malaria-related kidney injury and its link to chronic kidney disease in children

  This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11524896

• Boosting self-care and physical activity for older adults with chronic kidney disease

  This program helps older adults with chronic kidney disease build the skills, confidence, and motivation to be more physically active.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11506133

• Improving treatment and outcomes for veterans with chronic kidney disease

  This project looks at how different treatments and care patterns relate to health and racial disparities for veterans living with chronic kidney disease.

  NIH research Memphis VA Medical Center · Memphis, United States · NIH-11505524

• Ferric citrate therapy and kidney disease in children

  A multi-center study tests whether ferric citrate helps children with chronic kidney disease by affecting a specific blood marker over a year.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11505274

• Ferric citrate therapy for kids with chronic kidney disease

  A pediatric CKD study tests ferric citrate vs placebo over a year to see how it affects a blood biomarker inChildren aged 6–18.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11505273

• siRNA nanoparticle treatment to stop diabetic kidney damage

  A new nanoparticle-delivered gene-silencing treatment aims to lower kidney inflammation in people with diabetes to help protect their kidneys.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11501229

• Home-based conservative care for advanced kidney disease in older adults

  A patient-friendly look at a program that uses home-based, multidisciplinary care to support older Veterans with advanced kidney disease who choose to avoid dialysis.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11469481

• LRG1’s role in diabetic kidney disease and kidney fibrosis

  A study examines how a specific protein, LRG1, influences kidney disease related to diabetes and its scarring, with the aim of finding targeted ways to slow or prevent damage.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11466076

• APOL1 kidney disease link: how variants hurt kidney cells and how to help

  A small NIH grant is exploring why specific APOL1 gene variants can damage kidney cells and whether lowering a key enzyme, ACOX1, could protect against this injury.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11454419

• Weight management and center-based heart health program for Black adults with CKD

  A multi-component lifestyle program is tested to help Black adults with chronic kidney disease lower blood pressure and improve heart and kidney health.

  NIH research Duke University · Durham, United States · NIH-11453611

• Empowering Families with Culinary Medicine for Kids’ Kidney Health

  A family-friendly program would teach practical, tasty cooking skills to help children with CKD follow a renal-friendly diet.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11453123

• NRG4-ErbB4 signaling and kidney disease

  A study at Vanderbilt will explore how a specific protein signaling pathway (NRG4-ErbB4) affects kidney injury and scarring, with the goal of identifying new ways to protect kidney health in adults.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11447640

• Defining how the immune system and kidney cells interact in ARPKD

  A scientist is studying how genetic changes in ARPKD affect kidney and immune cell interactions, with the aim of finding new ways to help affected children.

  NIH research Children's Research Institute · Washington, United States · NIH-11437213

• How dialysis facility growth affects care for people with end-stage kidney disease

  New research will examine whether the spread of dialysis centers and new treatment technologies benefit patients with end-stage kidney disease, and whether benefits reach all communities.

  NIH research National Bureau of Economic Research · Cambridge, United States · NIH-11434364

• Understanding injured kidney cells to protect kidney health

  This NIH grant looks at a special type of damaged kidney cell and how it contributes to chronic kidney disease, with the aim of finding ways to protect kidney function.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11426830

• KUH-ART: Connecting Kidney, Urology and Hematology trainees and mentors

  A national networking platform for kidney, urology, and hematology trainees and mentors to share opportunities, build collaborations, and grow the next generation of KUH scientists.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11424195

• KUH-ART: Advanced Training in Kidney Disease, Urology and Hematology for clinicians and scientists

  A comprehensive training program at UCLA aims to equip clinicians and researchers with advanced skills in kidney disease, urology, and hematology using AI-enhanced approaches.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11424193

• KUH-ART: Advanced Research Training in Kidney, Urology, and Hematology for Adults

  A training program at UCLA aims to prepare graduate and postgraduate trainees to lead interdisciplinary kidney, urology, and hematology research and collaborations that could improve patient care.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11424192

• Reducing heart risk in kidney disease patients with ticagrelor

  A patient-friendly trial will test whether a heart medication called ticagrelor, added to standard care, can lower inflammation and markers linked to heart risk in people with chronic kidney disease.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11423446

• Role of cyclin G1 and CDK5 in kidney disease

  Aims to understand how specific cell-cycle regulators in kidney cells contribute to chronic kidney disease and fibrosis, with potential to guide new therapies.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11420976

• Mayo Clinic Polycystic Kidney Disease Research Core Center

  A Mayo Clinic program provides organizational leadership and coordination for PKD research, education, and community engagement to help people affected by polycystic kidney disease.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11418458

• Mayo Clinic Polycystic Kidney Disease Resource Center for PKD research

  A Mayo Clinic center provides researchers with PKD samples, data, and tools to help advance understanding and treatment of polycystic kidney disease.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11418445

• Targeting kidney disease in sickle cell with SGLT2 inhibitors

  A study to see if SGLT2 inhibitors can protect the kidneys of adults with sickle cell disease and related CKD.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11417914

• UAB Childhood Cystic Kidney Disease Center Resource Hub

  A specialized center will develop and validate new tools and resources to help researchers study childhood polycystic kidney diseases.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11416776

• PKD data and analytics hub to power patient-centered kidney research

  A national PKD data and informatics resource at UAB helps scientists study kidney disease with advanced genes and cell-level data to ultimately benefit patients with PKD.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11416771

• Bioengineering resources to model polycystic kidney disease (PKD)

  A public research center at UAB is building and sharing advanced PKD models—animal, cell-based, and human kidney organoids—to better understand PKD and test therapies.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11416769

• Childhood Cystic Kidney Disease Center: A Resource to Speed Pediatric PKD Translational Work

  A pediatric-focused resource center is being funded to help researchers move new cystic kidney disease discoveries into treatments for children.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11416763

• Childhood Cystic Kidney Disease Center Administrative Core

  A center hub at UAB that coordinates resources and support for research on childhood cystic kidney diseases to help patients in the long term.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11416757

• UAB Childhood Cystic Kidney Disease Center: Advancing PKD Care from Childhood to Translation

  A dedicated center at the University of Alabama at Birmingham is building resources to understand and treat polycystic kidney disease starting in childhood, with data, patient care insights, and new model systems to speed therapies.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11416743

• Hospital-to-SNF Transitions for Kidney Failure Patients

  Aimed at improving how patients with end-stage kidney disease move from hospital to skilled nursing facilities to reduce readmissions.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11416733

• Electronic tools to help doctors manage high blood pressure in kidney disease patients

  A multi-site study tests an electronic decision-support tool within primary care to help treat high blood pressure in adults with chronic kidney disease.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11416726

• Targeting Myosin to Treat Polycystic Kidney Disease

  A new approach tests drugs that activate a motor protein called NMII to slow or stop kidney cyst growth in people with polycystic kidney disease.

  NIH research Plurexa LLC · Seattle, UNITED STATES · NIH-11416614

• Multi-omics approach to classifying chronic kidney disease

  A large study using genetic, epigenetic, RNA, protein, and metabolite data from people with and without CKD to better define subtypes and guide personalized care.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11416290

• Medically tailored meals for children with kidney failure

  A study compares different ways to give tailored meals to kids with end-stage kidney disease to see what works best for families and health.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11415911

• Third Generation Polygenic Score for Chronic Kidney Disease

  Researchers are refining a genetic score to better predict kidney disease risk across diverse populations, aiming to help people understand their chances and guide care.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415894

Related topics

Quick answers

How many Kidney Disease clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (13 trials), Canada (4 trials), France (4 trials), Germany (4 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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