Personalized CKD-MBD care using systems biology and AI
Official title: Systems Biology Approach to the Management of Chronic Kidney Disease-Mineral Bone Disorder
Funded at VA North Texas Health Care System · NIH-11644324 · Data updated 2026-11-12
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA North Texas Health Care System NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | October 1, 2018 |
| Project end | September 30, 2027 |
| Funding year | 2027 |
| NIH project number | 5I01CX001614-08 |
| Project ID | NIH-11644324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease and CKD-MBD who are under care at Veterans Affairs facilities and are undergoing mineral metabolism management.
✕Less likely to help
Patients not undergoing CKD-MBD management or those without access to VA care may not directly benefit.
What this research studies
This project uses a systems biology model of mineral metabolism in CKD and artificial intelligence to guide treatment decisions for phosphate, calcium, and PTH. It emphasizes identifying patient subgroups with distinct disease courses so therapies can be personalized rather than one-size-fits-all. The approach combines measurable lab data with non-measurable clinical factors to predict responses to therapy and optimize outcomes. If successful, it could help reduce cardiovascular risks and improve survival for people with CKD-related bone and mineral disorders.
Why it matters
Potential benefit: If successful, patients could receive more effective, individualized treatment plans that better control mineral imbalances and potentially improve survival.
How similar studies have gone: Previous modeling and AI-guided approaches show promise, but this exact system-level, personalized strategy is being tested.
Where this research is happening
-
VA North Texas Health Care System
Dallas, United States Active
Researchers
- Principal investigator: Lederer, Eleanor D — VA North Texas Health Care System
- Study coordinator: Lederer, Eleanor D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.