Maribavir for CMV in adults with kidney failure after transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, retrospective chart-review of adults with severe chronic kidney disease or end-stage renal disease who received maribavir for refractory CMV after a solid organ or stem cell transplant. The study collects data already recorded during routine clinical care and does not change participants' treatment. Eligibility requires prior transplant, documented refractory CMV, severe CKD (eGFR 15–<30) or ESRD (eGFR <15 or on dialysis), and at least one dose of maribavir given in routine practice. The primary focus is safety in this high-risk kidney-impaired population across several European transplant centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults more than and equal to (≥) 18 years of age at index date.
* Diagnosis of comorbid ESRD or comorbid severe CKD prior to the index date.

  * If ESRD (including participants on peritoneal dialysis or hemodialysis): participant diagnosed with ESRD confirmed by an estimated glomerular filtration rate (eGFR) less than (\<) 15 milliliters per minute per 1.73 square meters (mL/min/1.73m\^2).
  * If severe CKD: participant diagnosed with severe CKD confirmed by an eGFR of 15 to \<30 mL/min/1.73m\^2 at index.
* Participant has undergone solid organ transplant (SOT) or hematopoietic stem cell transplantation (HSCT) before index date.
* Participant was diagnosed with refractory (with or without resistance) CMV during the latest post-transplant period.
* Participant initiated treatment with maribavir in routine practice within the eligibility period and received at least 1 dose of maribavir.
* Informed consent provided (where required by local regulations) before data collection commences.

Exclusion Criteria:

There are no exclusion criteria for this study.

Where it's running

• North Estonia Medical Centre Foundation
  Tallinn, Harju, Estonia Recruiting
• Tartu University Hospital
  Tartu, Estonia Recruiting
• CHU de Brest - Hopital La Cavale Blanche
  Brest, Finistere, France Recruiting
• CHU de Bordeaux - Hopital Pellegrin
  Bordeaux, Gironde, France Recruiting
• CHU de Montpellier - Hopital Lapeyronie
  Montpellier, Herault, France Recruiting
• CHU de Grenoble Alpes - Hopital Michallon
  La Tronche, Isere, France Recruiting

Study contacts

• Study coordinator: Takeda Contact
• Email: medinfoUS@takeda.com
• Phone: +1-877-825-3327

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Kidney and liver blood flow patterns after major trauma

  We will use bedside ultrasound to see whether abnormal kidney and liver blood flow patterns occur in adults admitted to the ICU after major trauma and whether those patterns link to acute kidney injury or the need for mechanical ventilation.

  Recruiting Azienda Usl di Bologna · Bologna · NCT07492511

• Omnisol-preserved kidneys before transplant (hypothermic machine perfusion)

  This study tests whether using Omnisol during hypothermic machine perfusion before kidney transplant can improve early graft function compared with standard preservation.

  Recruiting Vivalyx GmbH · Rotterdam · NCT07792317

• Pedal Pump Device for Lower Extremity Edema in Hospitalized Patients

  This study tests a foot-pump device to see if it is tolerable and can help reduce swelling in the legs of hospitalized patients with edema.

  Recruiting Hillcrest · Tulsa, Oklahoma · NCT07760363

• Adapting and testing PEN-Plus in Zambian primary care

  Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.

  Recruiting Centre for Infectious Disease Research in Zambia · Lusaka, Lusaka Province · NCT07753681

• Effects of general vs spinal-epidural anesthesia on kidney transplant biomarkers

  This study tests whether sevoflurane general anesthesia or combined spinal-epidural anesthesia changes markers of cellular stress and protective peptides in adults undergoing kidney transplantation.

  Recruiting University of Gaziantep · Gaziantep, State/Province · NCT07678073

• Impact of a Clinical Information System on hospital outcomes for adults with chronic diseases

  This study tests whether implementing a Clinical Information System helps reduce readmissions or death within 30 days after hospital discharge for adults with chronic conditions in Alberta.

  Recruiting University of Calgary · Calgary, Alberta · NCT07609381

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.