Impact of 177Lu-PSMA therapy on kidney function in prostate cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess how 177Lutetium-Prostate Specific Membrane Antigen (PSMA) Radioligand Therapy affects kidney function in patients with metastatic castration-resistant prostate cancer (mCRPC). It will monitor kidney function using routine markers like creatinine and cystatin C before, during, and after therapy, with follow-ups extending up to 5 years. The study will also collect additional biomarkers and patient-reported outcomes to identify risk factors for chronic kidney disease and correlate them with clinical data. A total of 100 patients will be included to ensure robust data collection and analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with mCRPC starting 177Lu-PSMA RLT at the Klinikum rechts der Isar at the time of therapy initiation (1st cycle).

Exclusion Criteria:

* Missing or incomplete informed consent.
* age below 18 years

Where it's running

• Klinikum rechts der Isar, München, Bavaria 81675
  Munich, Germany Recruiting

Study contacts

• Study coordinator: Hannah Schäfer/ Christoph Schmaderer
• Email: hannah.schaefer@mri.tum.de
• Phone: +49 - 89 4140 8383

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.