Bioengineering resources to model polycystic kidney disease (PKD)
Official title: UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC) - Bioengineering Resource
Funded at University of Alabama at Birmingham · NIH-11416769 · Data updated 2026-11-12
A public research center at UAB is building and sharing advanced PKD models—animal, cell-based, and human kidney organoids—to better understand PKD and test therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 20, 2020 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $254,614 |
| NIH project number | 5U54DK126087-07 |
| Project ID | NIH-11416769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to any single patient group; this is a resource for PKD researchers and future translational work.
✕Less likely to help
Direct patient benefit is unlikely in the short term; benefits are through advancing PKD research and potential therapies.
What this research studies
This project creates new animal models (rat and mouse) and human stem-cell–derived organoids that mimic PKD. It uses CRISPR/Cas9 and Halo/Snap tagging to study PKD proteins in living cells and tissues. The aim is to provide researchers with reliable models and tools to explore disease mechanisms and potential treatments. Resources will be distributed to the PKD research community to accelerate discovery.
Why it matters
Potential benefit: Advanced PKD models and tools could speed up development of effective therapies for patients with PKD.
How similar studies have gone: Similar model-generation efforts have yielded valuable insights in PKD research and supported drug development, though this is a resource-focused initiative.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Yoder, Bradley K. — University of Alabama at Birmingham
- Study coordinator: Yoder, Bradley K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.