Role of cyclin G1 and CDK5 in kidney disease
Official title: The role of cyclin G1 and CDK5 in chronic kidney disease
Funded at Ut Southwestern Medical Center · NIH-11420976 · Data updated 2026-11-12
Aims to understand how specific cell-cycle regulators in kidney cells contribute to chronic kidney disease and fibrosis, with potential to guide new therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $554,508 |
| NIH project number | 7R01DK121101-08 |
| Project ID | NIH-11420976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with chronic kidney disease, or future trials that test therapies targeting cyclin G1/CDK5 pathways.
✕Less likely to help
Patients without CKD or those not affected by kidney fibrosis may not benefit directly.
What this research studies
This project focuses on kidney proximal tubule cells and how they respond to injury. By using kidneys from animals lacking cyclin G1 or CDK5, researchers will separate the effects of cell-cycle arrest from true cell healing and fibrosis. The work aims to identify whether cyclin G1/CDK5-driven dedifferentiation promotes scarring, and whether blocking this pathway could reduce fibrosis. The findings could point to new targets to slow or prevent progression of CKD.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to prevent kidney fibrosis and preserve kidney function in CKD patients.
How similar studies have gone: Prior work has begun to map pathways involved in CKD-related fibrosis, with some promising targets, though this approach is relatively novel.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Brooks, Craig Robert — Ut Southwestern Medical Center
- Study coordinator: Brooks, Craig Robert
Related research
Other NIH-funded projects on the same topics.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
-
Boosting self-care and physical activity for older adults with chronic kidney disease
This program helps older adults with chronic kidney disease build the skills, confidence, and motivation to be more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.