Effects of general vs spinal-epidural anesthesia on kidney transplant biomarkers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective controlled study compares two anesthesia approaches in adult kidney transplant recipients. Blood samples will be taken around surgery to measure ferroptosis-related markers and mitochondrial peptides such as humanin and MOTS-c, to see which technique better preserves cellular stress balance. The trial aims to understand how anesthesia type may influence early biomarker signals after transplantation, potentially affecting graft outcomes. Only living-donor kidney transplant patients between 18 and 70 years old are included, with specific exclusions to minimize confounding factors. The lead sponsor is University of Gaziantep, with collaboration from The Scientific and Technological Research Council of Turkey, at Gaziantep University Faculty of Medicine Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18-70 years with American Society of Anesthesiologists (ASA) physical status I-III.
* Patients scheduled for elective living-donor allogeneic kidney transplantation.
* Patients receiving sevoflurane-based general anesthesia as the anesthetic technique.
* Patients receiving combined spinal-epidural anesthesia as the anesthetic technique.

Exclusion Criteria:

* Patients younger than 18 years or older than 70 years.
* Patients undergoing deceased-donor kidney transplantation.
* Patients receiving total intravenous anesthesia (TIVA).
* Patients who decline to participate in the study or are unable to provide informed consent.
* Patients with American Society of Anesthesiologists (ASA) physical status IV or V.
* Patients with a history of previous organ transplantation.
* Patients with known or suspected mitochondrial disorders.
* Patients with a history of chronic corticosteroid use.
* Patients requiring red blood cell transfusion intraoperatively or within the first 24 postoperative hours.
* Patients with a primary warm ischemia time \>5 minutes, secondary warm ischemia time \>30 minutes, or cold ischemia time \>60 minutes.

Where it's running

• Gaziantep University Faculty of Medicine Hospital
  Gaziantep, State/Province, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Berna KAYA UĞUR, Doç. Dr. — University of Gaziantep
• Study coordinator: Abdulkadir UÇAR, MD
• Email: drkadirucar@gmail.com
• Phone: +90 534 030 89 56

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.