Kidney and liver blood flow patterns after major trauma
Official title: Renal and hEpatiC abnoRmal dopplEr pAtterns iN Trauma: a Multicentre Prospective Observational Study
Run by Azienda Usl di Bologna · NCT07492511 · Data updated 2026-11-12
We will use bedside ultrasound to see whether abnormal kidney and liver blood flow patterns occur in adults admitted to the ICU after major trauma and whether those patterns link to acute kidney injury or the need for mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | Azienda Usl di Bologna Government |
| Locations | 1 site (Bologna) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | December 31, 2029 |
| Study ends | June 30, 2030 |
| Registry record updated | March 25, 2026 |
| Trial ID | NCT07492511 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with major trauma (Injury Severity Score >15) admitted within 24 hours to the ICU or HDU, without chronic heart failure, chronic kidney disease, chronic respiratory support, or renal injuries on CT that prevent Doppler assessment, are ideal candidates.
✕Probably not a fit
People under 18 or over 65, those with known heart failure (NYHA ≥II), chronic kidney disease or chronic dialysis, chronic respiratory disease requiring home oxygen or ventilation, or radiologic renal injury that prevents Doppler assessment are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study of adults (18–65) with major trauma (ISS >15) admitted to ICU or high-dependency units at a single center in Bologna. Trained operators will perform non-invasive bedside Doppler ultrasound to measure renal Doppler indices and a venous congestion score (RDRI and VExUS) at admission and at 24, 48, and 72 hours. The study will examine how common abnormal kidney and liver flow patterns are in the first 72 hours, the consistency of measurements between operators and sites, and whether those patterns are associated with acute kidney injury or need for mechanical ventilation. Kidney function will also be checked at 6 months after discharge to capture longer-term outcomes.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify early blood flow changes after trauma that predict kidney injury or respiratory support needs, enabling closer monitoring or earlier intervention.
How similar studies have gone: Prior single-center observational studies have suggested VExUS and renal Doppler relate to venous congestion and risk of AKI, but multicenter reliability and application specifically in major trauma patients remain less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-65 years; * Admission within 24h from traumatic injury; * ISS \>15 Exclusion Criteria: 1. Age \<18 or \>65; 2. Known heart failure (NYHA ≥II); 3. Chronic kidney disease (any stage) or chronic RRT; 4. Chronic respiratory disease needing home O₂ or ventilation; 5. Radiological evidence of vascular or parenchymal renal injury on trauma CT precluding reliable Doppler assessment
Where it's running
-
Ospedale Maggiore C.A. Pizzardi AUSL Bologna
Bologna, Italy Recruiting
Study contacts
- Study coordinator: Federico Moro, MD
- Email: federico.moro@ausl.bologna.it
- Phone: 0039 0516478215
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.