Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
Official title: Mitigating Diabetic Ketoacidosis in People with T1D and Chronic Kidney Disease on an SGLT1&2 Inhibitor: Ketosis Risk Factor Determination and Incorporation into an Enhanced Glucose Ketone Report
Funded at Healthpartners Institute · NIH-11595907 · Data updated 2026-11-12
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Healthpartners Institute NIH-funded |
| Lab location | 1 site (Bloomington, UNITED STATES) |
| Project start | September 21, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,542,828 |
| NIH project number | 3U01DK143379-01S1 |
| Project ID | NIH-11595907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 1 diabetes, with or without CKD, who are candidates for SGLT inhibitor therapy and can participate in continuous ketone and glucose monitoring.
✕Less likely to help
Patients not using SGLT inhibitors or without access to continuous glucose and ketone monitoring may not benefit.
What this research studies
If you have type 1 diabetes and kidney disease, this study will explore how real-time ketone monitoring can help doctors safely use SGLT inhibitors along with insulin. Researchers will collect glucose and ketone data, create a combined report, and test a risk mitigation plan to reduce DKA while aiming to improve overall health. The approach includes patients with and without CKD, categorized by KDIGO guidelines, to understand who may benefit most and how to prevent adverse events. The study will involve collaboration between clinicians and patients to determine practical ways to use DGK data in daily care. Outcomes may lead to safer, more effective use of SGLT inhibitors in this high-risk group.
Why it matters
Potential benefit: If successful, this could enable safer use of SGLT inhibitors for people with T1D and CKD, potentially improving glycemic control and reducing DKA risk.
How similar studies have gone: Previous research suggests that real-time monitoring and integrated data can support safer use of SGLT inhibitors, but this specific combination in T1D with CKD is exploratory.
Where this research is happening
-
Healthpartners Institute
Bloomington, United States Active
Researchers
- Principal investigator: Bergenstal, Richard Mauritz — Healthpartners Institute
- Study coordinator: Bergenstal, Richard Mauritz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.