Multi-omics approach to classifying chronic kidney disease
Official title: Multi-Omics for Chronic Kidney Disease
Funded at Columbia University Health Sciences · NIH-11416290 · Data updated 2026-11-12
A large study using genetic, epigenetic, RNA, protein, and metabolite data from people with and without CKD to better define subtypes and guide personalized care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 12, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $757,992 |
| NIH project number | 5U01HG013201-04 |
| Project ID | NIH-11416290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with non-diabetic CKD and adults without CKD who are willing to provide blood and urine samples for multi-omics analyses.
✕Less likely to help
Patients without CKD or those unwilling to provide biological samples may not directly benefit.
What this research studies
This project aims to collect and analyze blood and urine samples from 200 people with CKD and 100 without CKD over time, applying multiple high-tech 'omics' methods. By integrating genetic, epigenetic, transcriptomic, proteomic, and metabolomic data, researchers hope to identify molecular subtypes of non-diabetic CKD. The goal is to move beyond traditional diagnosis based on kidney function to a molecular-based classification that could inform tailored treatments. The study will be conducted at Columbia University and involves a Disease Study Site dedicated to CKD within the Multi-omics Health and Disease Consortium.
Why it matters
Potential benefit: If successful, patients could receive more precise diagnoses and personalized treatment options for CKD based on their molecular profile.
How similar studies have gone: Prior multi-omics efforts have shown promise in characterizing disease heterogeneity, with growing interest in CKD-specific molecular subtypes.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Kiryluk, Krzysztof — Columbia University Health Sciences
- Study coordinator: Kiryluk, Krzysztof
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.