Defining how the immune system and kidney cells interact in ARPKD
Official title: Defining immunomodulatory mechanisms in autosomal recessive polycystic kidney disease
Funded at Children's Research Institute · NIH-11437213 · Data updated 2026-11-12
A scientist is studying how genetic changes in ARPKD affect kidney and immune cell interactions, with the aim of finding new ways to help affected children.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $156,814 |
| NIH project number | 1K08DK149197-01 |
| Project ID | NIH-11437213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with ARPKD or those who have contributed ARPKD tissue samples for study, as well as neonates and children whose disease models can be mirrored in the DKO mouse.
✕Less likely to help
Patients without ARPKD or without access to related tissue samples may not directly benefit from this specific work.
What this research studies
This grant uses a special mouse model that mimics human ARPKD kidney disease and combines data from human tissues to explore how kidney cells communicate with immune cells. The work focuses on understanding how disruptions in epithelial cells and immune signaling contribute to kidney cysts, scarring, and loss of function. The study plans to test ideas in mice, and compare findings with human ARPKD samples to pinpoint potential targets for therapies. The goal is to uncover mechanisms that could lead to targeted treatments for kids with ARPKD.
Why it matters
Potential benefit: If successful, the research could identify new targets for therapies that slow or prevent kidney damage in ARPKD.
How similar studies have gone: Previous ARPKD models have guided understanding, but this project proposes a novel double knockout mouse that may better mirror human kidney disease.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Gulati, Ashima — Children's Research Institute
- Study coordinator: Gulati, Ashima
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.