Third Generation Polygenic Score for Chronic Kidney Disease
Funded at Columbia University Health Sciences · NIH-11415894 · Data updated 2026-11-12
Researchers are refining a genetic score to better predict kidney disease risk across diverse populations, aiming to help people understand their chances and guide care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $715,190 |
| NIH project number | 5R01DK144793-02 |
| Project ID | NIH-11415894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for or living with chronic kidney disease, including individuals of African, Asian, and other ancestries, whose data could improve risk prediction models.
✕Less likely to help
Patients without access to genetic testing or those not represented in the target ancestral groups may see limited benefit.
What this research studies
This project develops a genome-wide polygenic score (GPS) tailored for chronic kidney disease and tests its performance across different ancestries. It builds on earlier GPS work by using larger, more diverse genetic data and advanced methods to improve accuracy and portability. The goal is to provide clinically meaningful risk information that can inform prevention and management for adults with or at risk for AKPD/ADPKD. The study will leverage existing genomic data and statistical techniques to enhance prediction in multi-ethnic populations.
Why it matters
Potential benefit: If successful, patients could receive more accurate CKD risk information to personalize monitoring and preventive strategies.
How similar studies have gone: Prior GPS work showed that top risk percentiles correlated with substantially higher CKD risk across ancestries, informing clinical relevance.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Kiryluk, Krzysztof — Columbia University Health Sciences
- Study coordinator: Kiryluk, Krzysztof
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.