Investigating the link between brain inflammation and postoperative delirium in older adults
Neuroinflammation, Perineural Nets, and Postoperative Delirium
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11158613
This study is looking at how inflammation in the brain during surgery might lead to confusion and memory problems afterward, especially in older adults, and it will check how certain brain structures are affected to help understand these changes better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11158613 on ClinicalTrials.gov |
What this research studies
This research explores how neuroinflammation in the aging brain contributes to postoperative delirium (POD) and its potential progression to Alzheimer's disease and related dementias. By examining the role of perineural nets, which are structures that support neuron function, the study aims to understand how these nets are affected by inflammation during surgery. The research involves using advanced imaging techniques to observe changes in the brain's extracellular matrix and its impact on cognitive outcomes after surgery. Patients may be monitored for signs of delirium and cognitive decline following surgical procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are scheduled to undergo surgery and may be at risk for postoperative delirium.
Not a fit: Patients who are not undergoing surgery or who are younger and not at risk for delirium may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing postoperative delirium and reducing the risk of developing Alzheimer's disease in older patients.
How similar studies have performed: Previous research has shown that addressing neuroinflammation can positively impact cognitive outcomes in older adults, suggesting that this approach may yield beneficial results.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, SHIQIAN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SHEN, SHIQIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.