Combining cycling and cognitive training for ICU survivors
Official title: Simultaneous Recumbent Cycling and Cognitive Training on Cognition in Intensive Care Unit Survivors: a Randomized Control Trial
Run by University of Missouri, Kansas City · NCT04556227 · Data updated 2026-11-12
This study is testing whether a 12-week program that combines cycling and brain exercises can help improve thinking skills and quality of life for middle-aged people who have survived an ICU stay with delirium.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 64 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Missouri, Kansas City Academic / other |
| Drugs / interventions | Chemotherapy |
| Locations | 1 site (Kansas City, Missouri) |
| Status | Recruiting |
| Started | December 3, 2024 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | December 6, 2024 |
| Trial ID | NCT04556227 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking individuals aged 45-64 who have been admitted to an ICU for more than 24 hours and have experienced at least one episode of delirium.
✕Probably not a fit
Patients with severe cognitive impairments, neurodegenerative diseases, or conditions that prevent participation in rehabilitation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of simultaneous recumbent cycling and cognitive training on cognition and quality of life in middle-aged ICU survivors who have experienced delirium. Participants will engage in a 12-week program that combines physical exercise with cognitive tasks, followed by a 6-month maintenance phase. The study will assess cognitive function and quality of life at multiple time points using validated measures. It aims to determine the feasibility and acceptability of this combined intervention in improving outcomes for ICU survivors.
Why it matters
Potential benefit: If successful, this approach could significantly enhance cognitive function and quality of life for ICU survivors suffering from delirium.
How similar studies have gone: While the combination of physical exercise and cognitive training is emerging, this specific approach has not been extensively tested in similar populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 45-64 years * Admitted to medical or surgical ICUs (SLH \& TMC) for \>24 hours * English-speaking * Discharged home * Able to provide consent * Access to a telephone * One or more delirium episode in ICU (positive CAM-ICU). Exclusion Criteria: * Cancer diagnosis with short life expectancy determined by the Primary Care Provider (unable to complete the study within time frame) * Chemotherapy (drug-induced impaired cognition) * Diagnosed vascular dementia or other neurodegenerative diseases (e.g. Alzheimer or Parkinson disease) * Documented alcohol consumption ≥5 drinks/day (withdrawal delirium tremens) * Corrected vision\<20/80 Snellen chart (unable to do cognitive exercises on the tablet) * Examiner rated low hearing or communicative ability that would interfere with intervention and assessments * Positive CAM-ICU (delirium) at hospital discharge * Unable to participate in rehabilitation (abnormal 6 min walk test) * Any physical condition preventing recumbent cycling * Recent documented history of drug abuse.
Where it's running
-
St. Luke's Hospital of Kansas City
Kansas City, Missouri, United States Recruiting
Study contacts
- Principal investigator: Rita S Lasiter, PhD — University of Missouri, Kansas City
- Study coordinator: Rita S Lasiter, PhD
- Email: LasiterR@umkc.edu
- Phone: 816-235-6766
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Can citicoline help prevent cognitive decline after delirium in older adults with hip fracture?
This study tests whether taking citicoline for 6 months after discharge helps prevent cognitive decline in adults 65 and older who had delirium during hospitalization for hip fracture.
-
Delirium and Light: Exploring Modifiable Risk Factors in Critically Ill Adults
This pilot observational study tests whether circadian-light factors influence delirium risk in adults recovering in critical care.
-
VR-based cognitive games to help prevent delirium after big surgery
A VR-based cognitive stimulation game is being tested to see if it can help prevent delirium in adults 65 and older after major surgery.
-
Computer-assisted cognitive stimulation for delirium in older adults
This will try adding tablet-based cognitive exercises to sleep and mobility support to see if they reduce delirium in people aged 60 and older in subacute care.
-
Letting patients drink clear fluids until called to the operating room to shorten pre-surgery fasting
This project will try letting elective procedure patients drink clear liquids until they're called to the operating room to see if fasting times, comfort, and perioperative outcomes improve.
-
Lemborexant to help Sleep and Delirium in older ICU patients
This study tests whether lemborexant, a sleep medication, helps improve sleep and reduce delirium in adults 65 and older in the ICU.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.