Commercialization of an EEG-guided anesthesia system to reduce delirium in older adults and those at risk for Alzheimer’s
Official title: Commercialization Readiness of an Intraoperative EEG-Guided Precision Anesthesia Management System to Prevent Postoperative Delirium in Elderly and Patients at Risk for Alzheimer's & Related Dementia
Funded at Pascall Systems, Incorporated · NIH-11419843 · Data updated 2026-11-12
A new wireless EEG-guided anesthesia system aims to reduce postoperative delirium in seniors and people with or at risk for Alzheimer’s by personalizing brain monitoring during surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pascall Systems, Incorporated NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | September 20, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,998,482 |
| NIH project number | 5SB1AG097192-02 |
| Project ID | NIH-11419843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults (60+) undergoing general anesthesia, including those with Alzheimer’s disease and related dementias or at risk for ADRD.
✕Less likely to help
Patients without anesthesia exposure or those not at risk for delirium may not benefit.
What this research studies
This grant supports bringing a brain-monitoring system (M0) and its personalized algorithms (PASCALL M1) from development toward market readiness, including planning a large Phase III trial and refining clinical workflows. It builds on prior work that created the monitoring device and algorithms tailored for aging and dementia patients. The project will pilot study design elements, cost estimates, and timelines to optimize study processes, caregiver protocols, and outcome measures. The ultimate goal is to improve anesthesia safety and reduce delirium for patients with Alzheimer’s disease and related dementias.
Why it matters
Potential benefit: If successful, patients could experience fewer delirium events after surgery and better overall recovery.
How similar studies have gone: Previous work established a wireless brain monitor and personalized algorithms; this grant focuses on commercialization and Phase III planning to build on that success.
Where this research is happening
-
Pascall Systems, Incorporated
Boston, United States Active
Researchers
- Principal investigator: Le Mau, Tuan — Pascall Systems, Incorporated
- Study coordinator: Le Mau, Tuan
Related research
Other NIH-funded projects on the same topics.
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How surgery-related inflammation affects brain blood vessels in people with dementia
This project aims to find how inflammation from surgery harms the brain's blood vessels and leads to sudden delirium in older adults with dementia.
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How surgery affects brain function in older adults with dementia.
This study is looking at how surgery affects the brains of older adults with dementia, especially how inflammation from the surgery might lead to confusion or delirium, and it aims to find ways to help these patients feel better after their operations.
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Continuous wearable monitor with AI to prevent agitation and delirium in hospitalized older adults
A wearable sensor and AI system will continuously track agitation in older hospital patients to help prevent delirium and protect brain health.
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Why dementia and sudden confusion (delirium) often happen together
This project looks at brain electrical signals and chemical changes to find why people with dementia sometimes develop sudden confusion called delirium.
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Lipocalin-2 and delirium after surgery in Alzheimer’s disease and related dementias
A study at Duke University looks at how an inflammatory protein called lipocalin-2 may trigger delirium after surgery, especially in people at risk for Alzheimer’s and related dementias.
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Delirium after surgery and its link to Alzheimer's and related dementias
This project looks at why older adults and people with or at risk for Alzheimer's can get delirium after surgery and how that might increase later dementia risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.