Analyzing cerebrospinal fluid in patients with delirium
Official title: MOLECULAR BIOMARKERS IN DELIRIUM AND DEMENTIA
Run by Oslo University Hospital · NCT05060614 · Data updated 2026-11-12
This study is trying to find out if certain markers in the spinal fluid of people with delirium, especially those who have had hip fractures, can help us understand how delirium is connected to dementia.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | Oslo University Hospital Academic / other |
| Locations | 1 site (Oslo, Other) |
| Status | Recruiting |
| Started | September 1, 2016 |
| Main results expected | December 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | March 12, 2024 |
| Trial ID | NCT05060614 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with acute hip fractures who are experiencing delirium.
✕Probably not a fit
Patients who are moribund or unable to provide consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to measure biomarkers in cerebrospinal fluid (CSF) and serum samples from patients experiencing delirium, particularly those with acute hip fractures. By investigating these biomarkers, the study seeks to uncover insights into the pathophysiology of delirium and its potential connections to dementia. The research focuses on understanding the molecular mechanisms that may link these two conditions, which share clinical and epidemiological features. The findings could enhance our knowledge of delirium and its implications for dementia progression.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of delirium, potentially reducing its impact on dementia progression.
How similar studies have gone: While the exploration of biomarkers in delirium is an emerging field, similar studies have shown promise in understanding the connections between acute cognitive disturbances and neurodegenerative conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with acute hip fracture Exclusion Criteria: * Moribund patients. * Lack of consent
Where it's running
-
Leiv Otto Watne
Oslo, Other, Norway Recruiting
Study contacts
- Principal investigator: Leiv O Watne, PhD — Oslo University Hospital
- Study coordinator: Leiv O Watne, PhD
- Email: l.o.watne@gmail.com
- Phone: 40203712
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Can citicoline help prevent cognitive decline after delirium in older adults with hip fracture?
This study tests whether taking citicoline for 6 months after discharge helps prevent cognitive decline in adults 65 and older who had delirium during hospitalization for hip fracture.
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Delirium and Light: Exploring Modifiable Risk Factors in Critically Ill Adults
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.