Understanding how epigenetics affects delirium and cognitive decline in elderly patients with dementia
Official title: Epigenetics Biomarker of Post Operative Delirium and Long Term Cognitive Decline among Elderly Dementia Patients
Funded at Stanford University · NIH-11174306 · Data updated 2026-11-12
This study is looking at how changes in our genes might help us understand the risk of confusion and memory problems after surgery in older adults with dementia, so we can find better ways to spot and help those who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,116,265 |
| NIH project number | 5R01AG084710-02 |
| Project ID | NIH-11174306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly patients diagnosed with dementia who are scheduled for surgical procedures.
✕Less likely to help
Patients who are not elderly or do not have a diagnosis of dementia may not benefit from this research.
What this research studies
This research investigates the connection between epigenetic changes and the risk of developing delirium and long-term cognitive decline in elderly patients suffering from dementia. By focusing on DNA methylation, a type of epigenetic modification influenced by environmental factors, the study aims to identify biomarkers that can predict post-operative delirium. The research will involve analyzing how inflammation and aging contribute to these cognitive issues, particularly in patients undergoing surgery, which is a known risk factor for delirium. The ultimate goal is to improve early identification and treatment strategies for at-risk patients.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management of delirium and cognitive decline in elderly dementia patients, potentially improving their post-operative outcomes.
How similar studies have gone: Previous research has indicated that understanding the role of inflammation and cytokines in delirium may lead to significant advancements, suggesting that this approach has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Shinozaki, Gen — Stanford University
- Study coordinator: Shinozaki, Gen
Related research
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Longitudinal multi-omics map of cognitive decline and dementia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.