Intraoperative EEG-Guided Anesthesia to Reduce Delirium in Older Adults and Those with Alzheimer’s or Related Dementias
Official title: Developing an Intraoperative EEG-Guided Precision Anesthesia Management System to Prevent Postoperative Delirium in Elderly and Patients at Risk for Alzheimer's & Related Dementias
Funded at Pascall Systems, Incorporated · NIH-11382203 · Data updated 2026-11-12
A new system uses brainwave monitoring during surgery to tailor anesthesia and reduce delirium risk in older patients and those with Alzheimer’s disease or related dementias.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pascall Systems, Incorporated NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | February 1, 2020 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,499,986 |
| NIH project number | 5R44AG066325-05 |
| Project ID | NIH-11382203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults (typically 60+) and patients with Alzheimer’s disease or related dementias who are undergoing general anesthesia.
✕Less likely to help
Patients without ADRD or younger patients may not experience the same level of benefit.
What this research studies
This project aims to commercialize a wireless brain-monitoring device and personalized anesthesia algorithms that adapt to aging and ADRD patients. By validating the monitoring index with existing and new patient data, the team seeks to ensure accurate guidance for anesthesia levels during procedures. The effort combines technical development, regulatory planning, and a go-to-market strategy to bring a tailored, brain-based approach to operating rooms with the goal of lowering postoperative delirium. If successful, patients could experience fewer delirium episodes and smoother recoveries after surgery.
Why it matters
Potential benefit: Could lead to fewer cases of postoperative delirium and better recovery for older adults and those with ADRD who undergo surgery.
How similar studies have gone: Previous work demonstrated a wireless brain monitor and personalized anesthesia strategies; this grant focuses on validating and accelerating commercialization for ADRD populations.
Where this research is happening
-
Pascall Systems, Incorporated
Boston, United States Active
Researchers
- Principal investigator: Le Mau, Tuan — Pascall Systems, Incorporated
- Study coordinator: Le Mau, Tuan
Related research
Other NIH-funded projects on the same topics.
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Lipocalin-2 and delirium after surgery in Alzheimer’s disease and related dementias
A study at Duke University looks at how an inflammatory protein called lipocalin-2 may trigger delirium after surgery, especially in people at risk for Alzheimer’s and related dementias.
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Commercialization of an EEG-guided anesthesia system to reduce delirium in older adults and those at risk for Alzheimer’s
A new wireless EEG-guided anesthesia system aims to reduce postoperative delirium in seniors and people with or at risk for Alzheimer’s by personalizing brain monitoring during surgery.
-
Delirium after surgery and its link to Alzheimer's and related dementias
This project looks at why older adults and people with or at risk for Alzheimer's can get delirium after surgery and how that might increase later dementia risk.
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Understanding how blood biomarkers link delirium after surgery to Alzheimer’s disease
This study tests whether blood markers of Alzheimer's disease can predict and explain delirium after surgery in older adults.
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Neuroinflammation, Protective Brain Scaffolds, and Delirium After Surgery
This project looks at why older people often get delirium after surgery and how brain tissues called perineural nets might influence this, with the goal of improving outcomes for people at risk of Alzheimer’s-related conditions.
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Integrated Brain State Monitor to Help Personalize Anesthesia and Prevent Delirium in Older Adults
A new, brain-monitoring system aims to personalize anesthesia care for older adults and people at risk for Alzheimer's, with the goal of reducing postoperative delirium.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.