Delirium and Light: Exploring Modifiable Risk Factors in Critically Ill Adults
Official title: DElirium and LIGHT: Exploring Modifiable Risk Factors of Delirium - a Pilot Study
Run by King's College Hospital NHS Trust · NCT07791472 · Data updated 2026-11-12
This pilot observational study tests whether circadian-light factors influence delirium risk in adults recovering in critical care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | King's College Hospital NHS Trust Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | August 2026 |
| Main results expected | February 2027 |
| Study ends | May 2027 |
| Registry record updated | August 28, 2026 |
| Trial ID | NCT07791472 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 50 who have just entered critical care, with accessible lines for blood sampling and expected ICU stay longer than 36 hours.
✕Probably not a fit
Patients without delirium risk factors or with conditions that limit participation may not benefit from this observational approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot observational study, conducted at a major hospital network, follows adults over 50 who have recently been admitted to critical care to see if light exposure and sleep patterns relate to delirium risk. It will collect blood samples and monitor daytime light exposure to explore possible connections with delirium and cognitive outcomes. The goal is to identify modifiable factors that could help reduce delirium and inform future interventions in the ICU setting.
Why it matters
Potential benefit: If successful, the study could guide simple changes in lighting or daily routines to lower delirium risk in critically ill patients.
How similar studies have gone: Previous work suggests circadian disruption may be linked to delirium, but direct measurements in ICU settings are limited and this pilot adds new observational data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients \>50 years old * Patients admitted to critical care in previous 24 hours * Patients with an arterial or venous access line suitable for blood sampling * Patients with an expected length of stay \>36 hours Exclusion Criteria: * Patients with a primary neurosurgical diagnosis * Patients with pre-existing cognitive impairment * Patients expected to die within 24 hours or receiving end of life treatment
Where it's running
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King's College Hospital NHS Foundation Trust
London, United Kingdom Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.