Clinical trial Recruiting at 1 site Observational Ages 50 and up

Delirium and Light: Exploring Modifiable Risk Factors in Critically Ill Adults

Official title: DElirium and LIGHT: Exploring Modifiable Risk Factors of Delirium - a Pilot Study

Run by King's College Hospital NHS Trust · NCT07791472 · Data updated 2026-11-12

This pilot observational study tests whether circadian-light factors influence delirium risk in adults recovering in critical care.

Quick facts

Study typeObservational
Ages50 Years and up
SexAll
Enrollment10 (estimated)
SponsorKing's College Hospital NHS Trust
Academic / other
Locations1 site (London)
StatusRecruiting
StartedAugust 2026
Main results expectedFebruary 2027
Study endsMay 2027
Registry record updatedAugust 28, 2026
Trial IDNCT07791472 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults over 50 who have just entered critical care, with accessible lines for blood sampling and expected ICU stay longer than 36 hours.

Probably not a fit

Patients without delirium risk factors or with conditions that limit participation may not benefit from this observational approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot observational study, conducted at a major hospital network, follows adults over 50 who have recently been admitted to critical care to see if light exposure and sleep patterns relate to delirium risk. It will collect blood samples and monitor daytime light exposure to explore possible connections with delirium and cognitive outcomes. The goal is to identify modifiable factors that could help reduce delirium and inform future interventions in the ICU setting.

Why it matters

Potential benefit: If successful, the study could guide simple changes in lighting or daily routines to lower delirium risk in critically ill patients.

How similar studies have gone: Previous work suggests circadian disruption may be linked to delirium, but direct measurements in ICU settings are limited and this pilot adds new observational data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients \>50 years old
* Patients admitted to critical care in previous 24 hours
* Patients with an arterial or venous access line suitable for blood sampling
* Patients with an expected length of stay \>36 hours

Exclusion Criteria:

* Patients with a primary neurosurgical diagnosis
* Patients with pre-existing cognitive impairment
* Patients expected to die within 24 hours or receiving end of life treatment

Where it's running

  • King's College Hospital NHS Foundation Trust
    London, United Kingdom
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.