Monitoring anticoagulation and inflammation in patients after heart and vascular surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the most effective monitoring tools for unfractionated heparin (UFH) in patients undergoing major heart and vascular surgeries. It will compare various monitoring modalities, such as activated clotting time (ACT), activated partial thromboplastin time (aPTT), viscoelastic tests (ROTEM), and anti-Xa levels, to assess their association with adverse events like thrombosis and bleeding. Additionally, the study will explore the relationship between inflammation and delirium in these patients. By identifying the best monitoring practices, the study seeks to enhance patient safety and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: \> 17 years
* Informed written consent
* Scheduled for cardiac intervention where the use of UFH is expected (elective surgery)
* Scheduled for vascular intervention when the need for perioperative anticoagulation is expected (elective surgery)
* Patients receiving ECMO support

Exclusion Criteria:

* Patients that are known to be pregnant
* Known participation in other interventional clinical trial

Where it's running

• Medical University Innsbruck
  Innsbruck, Tyrol, Austria Recruiting

Study contacts

• Study coordinator: Sasa Rajsic, MD, PhD
• Email: sasa.rajsic@tirol-kliniken.at
• Phone: 004367763004447

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Can citicoline help prevent cognitive decline after delirium in older adults with hip fracture?

  This study tests whether taking citicoline for 6 months after discharge helps prevent cognitive decline in adults 65 and older who had delirium during hospitalization for hip fracture.

  Recruiting Phase 2 University of Milano Bicocca · Monza, Monza E Brianza · NCT07804498

• Delirium and Light: Exploring Modifiable Risk Factors in Critically Ill Adults

  This pilot observational study tests whether circadian-light factors influence delirium risk in adults recovering in critical care.

  Recruiting King's College Hospital NHS Trust · London · NCT07791472

• Appropriateness of Hemostatic Agent Use in Cardiovascular Surgery

  This study tests how well surgeons’ choices about topical hemostatic agents match current guidelines in cardiac and vascular surgery at one Milan hospital.

  Recruiting University of Milan · Milan, MI · NCT07699016

• VR-based cognitive games to help prevent delirium after big surgery

  A VR-based cognitive stimulation game is being tested to see if it can help prevent delirium in adults 65 and older after major surgery.

  Recruiting at 2 sites The Methodist Hospital Research Institute · Houston, Texas and 1 other locations · NCT07641153

• Computer-assisted cognitive stimulation for delirium in older adults

  This will try adding tablet-based cognitive exercises to sleep and mobility support to see if they reduce delirium in people aged 60 and older in subacute care.

  Recruiting Institut Investigacio Sanitaria Pere Virgili · Reus, Tarragona · NCT07563244

• Letting patients drink clear fluids until called to the operating room to shorten pre-surgery fasting

  This project will try letting elective procedure patients drink clear liquids until they're called to the operating room to see if fasting times, comfort, and perioperative outcomes improve.

  Recruiting University of Giessen · Giessen · NCT07488468

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.