Using brain stimulation to reduce delirium in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine if transcranial alternating current stimulation (TACS) can effectively shorten the duration of delirium in patients in an intensive care unit (ICU). Participants will receive either the experimental TACS treatment or a sham treatment over a maximum of two days, depending on their delirium status. The primary outcome measured will be the number of days patients are alive and free of delirium. The study is based on the premise that TACS can modulate brain activity and improve cognitive functions, potentially addressing the underlying pathophysiology of delirium.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Delirium in intensive care and duration of delirium for more than 24 hours. Delirium is defined as 4 or more points on ICDSC and -1 or more points on RASS.

Exclusion Criteria:

* Under 18 years of age, pregnancy, delirium tremens, epilepsy or history of seizures any time before first trial intervention, active psychotic disease, infection of central nervous system, acute intoxication, traumatic brain injury, stroke, intracranial bleeding and implanted electronic devices.

Where it's running

• Kuopio University Hospital
  Kuopio, Finland Recruiting

Study contacts

• Principal investigator: Stepani Bendel — Kuopio University Hospital
• Study coordinator: Ville Ihalainen
• Email: ville.ihalainen@pshyvinvointialue.fi
• Phone: +358 447176388

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.