Integrated Brain State Monitor to Help Personalize Anesthesia and Prevent Delirium in Older Adults

Who could benefit from this research

What this research studies

This grant supports developing a wireless brain-monitoring system that works with hospital computers and anesthesia machines to guide anesthesia care for older patients and those with dementia risk. The project has three steps: connect the monitor with EMR and devices, develop a next-generation M1 system that meets regulatory standards, and add features to predict POD and guide dosing. The approach focuses on tailoring anesthesia to an individual’s brain state to prevent delirium after surgery. If successful, it could lead to safer anesthesia and fewer POD-related complications for at-risk patients.

Why it matters

Where this research is happening

• Pascall Systems, Incorporated
  Boston, United States Active

Researchers

• Principal investigator: Le Mau, Tuan — Pascall Systems, Incorporated
• Study coordinator: Le Mau, Tuan

Related research

Other NIH-funded projects on the same topics.

• Lipocalin-2 and delirium after surgery in Alzheimer’s disease and related dementias

  A study at Duke University looks at how an inflammatory protein called lipocalin-2 may trigger delirium after surgery, especially in people at risk for Alzheimer’s and related dementias.

  NIH research Duke University · Durham, United States · NIH-11464607

• Commercialization of an EEG-guided anesthesia system to reduce delirium in older adults and those at risk for Alzheimer’s

  A new wireless EEG-guided anesthesia system aims to reduce postoperative delirium in seniors and people with or at risk for Alzheimer’s by personalizing brain monitoring during surgery.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11419843

• Delirium after surgery and its link to Alzheimer's and related dementias

  This project looks at why older adults and people with or at risk for Alzheimer's can get delirium after surgery and how that might increase later dementia risk.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11395067

• Intraoperative EEG-Guided Anesthesia to Reduce Delirium in Older Adults and Those with Alzheimer’s or Related Dementias

  A new system uses brainwave monitoring during surgery to tailor anesthesia and reduce delirium risk in older patients and those with Alzheimer’s disease or related dementias.

  NIH research Pascall Systems, Incorporated · Boston, UNITED STATES · NIH-11382203

• Understanding how blood biomarkers link delirium after surgery to Alzheimer’s disease

  This study tests whether blood markers of Alzheimer's disease can predict and explain delirium after surgery in older adults.

  NIH research Duke University · Durham, United States · NIH-11374271

• Neuroinflammation, Protective Brain Scaffolds, and Delirium After Surgery

  This project looks at why older people often get delirium after surgery and how brain tissues called perineural nets might influence this, with the goal of improving outcomes for people at risk of Alzheimer’s-related conditions.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11345862

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.