Preserving the superior left colic artery to improve blood flow to the descending colon before reconnecting the bowel after left-sided, rectal, or ovarian cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Surgeons will temporarily clamp and then restore arterial flow of the inferior mesenteric artery while preserving the superior left colic artery to evaluate perfusion of the descending colon prior to performing colorectal anastomosis. Perfusion will be assessed intraoperatively, likely using indocyanine green fluorescence angiography where appropriate, to guide the surgical decision about the length and viability of the bowel to be reconnected. The procedure is applied to adults undergoing left colectomy, rectal resection, or ovarian cytoreductive surgery that requires colorectal resection. Outcomes of interest include measures of colonic vascularization and postoperative anastomotic complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male/ female aged over 18 years,
* Histologically proven left colon or rectal adenocarcinoma OR ovarian carcinoma (with potential colorectal resection),
* Scheduled surgery for left colic or rectal carcinoma// Scheduled surgery for ovarian carcinoma with potential colorectal resection,
* Surgical indication of colo-rectal resection validated in RCP and confirmed during the operative exploration (ovarian cancer,
* WHO Status \< 3
* Patient who has given informed, written and express consent,
* Patient (s) affiliated to a French social security.

Exclusion Criteria:

* Contraindication to indocyanine green: thyroid adenoma, hyperthyroidism, hypersensitivity or allergy to one of the components, severe renal failure (GFR \<30 ml/min/1.73m2),
* Patient with a history of abdominal vascular surgery
* Patient (e) not having left colic artery on vascular mapping of preoperative abdominal-pelvic scanners,
* Patient whose regular follow-up is not possible for psychological, family, social or geographical reasons,
* Patient (s) under guardianship, curatorship or safeguard of justice,
* Pregnant and/or breastfeeding patient,

Where it's running

• Icm Val D'Aurelle
  Montpellier, Herault, France Recruiting

Study contacts

• Study coordinator: Aurore MOUSSION
• Email: aurore.moussion@icm.unicancer.fr
• Phone: 467613102

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.