Understanding DNA Changes in Colon Cancer
Official title: Mechanisms of DNA methylation signaling and dysregulation in colon cancer
Funded at Van Andel Research Institute · NIH-11129879 · Data updated 2026-11-12
This research explores how abnormal DNA changes contribute to colon cancer and seeks new ways to target them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | July 2, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $632,319 |
| NIH project number | 5R01CA283463-02 |
| Project ID | NIH-11129879 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not directly involve patients, but future clinical trials stemming from this work would likely target individuals with colon cancer.
✕Less likely to help
Patients not diagnosed with colon cancer would not directly benefit from this specific research.
What this research studies
Colon cancer is a serious disease, and this research focuses on understanding abnormal DNA changes, called DNA methylation, which are common in this cancer. These changes can make the genome unstable and silence important genes that normally fight cancer. We are looking into the specific processes that cause these DNA changes and how they lead to colon cancer development. Our work will also consider if targeting these processes could lead to new treatments.
Why it matters
Potential benefit: If successful, this research could uncover new ways to treat colon cancer by correcting or interfering with abnormal DNA changes.
How similar studies have gone: While the role of DNA methylation in cancer is known, this specific approach to understanding the causal mechanisms and targeting ubiquitin signaling in this context is exploring new territory.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Rothbart, Scott — Van Andel Research Institute
- Study coordinator: Rothbart, Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.