Using ctDNA to guide chemotherapy for elderly colon cancer patients after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of ctDNA detection in guiding adjuvant chemotherapy regimens for elderly patients with high-risk stage II and III colon cancer. Participants will undergo ctDNA testing post-surgery to assess their disease status and will be monitored for disease-free survival. Based on ctDNA results, patients will be randomized to receive either observation or specific chemotherapy treatments. The study aims to correlate ctDNA status with imaging results and patient prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged 70-80, both male and female are eligible;
2. Patients with histopathologically confirmed stage II high-risk or stage III colon cancer;
3. Patients with an ECOG score of ≤2;
4. Patients who are required to undergo tissue genetic testing;
5. Subjects who voluntarily participate in this study, sign the informed consent form, have good compliance, and cooperate with follow-up visits.

Exclusion Criteria:

1. Patients with one or more severe concomitant systemic diseases that, in the investigator\'s opinion, would impair the patient\'s ability to complete the study.
2. Patients who have had a history of malignant tumors within 5 years.
3. Any unstable systemic disease (including active infection, poorly controlled diabetes, poorly controlled hypertension, unstable angina, congestive heart failure, myocardial infarction within one year, severe arrhythmia requiring medical treatment, liver, kidney, or metabolic diseases).
4. Patients suffering from severe mental illnesses.
5. Patients who have participated in other clinical trials within 30 days prior to screening.
6. Patients who are unable to undergo adjuvant chemotherapy.

Where it's running

• Zhejiang Cancer Hospital
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Yuping Zhu, M.D.
• Email: drzyp@163.com
• Phone: 86-0571-88128011

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.