ALOX15's role in colon cancer spread through PI3P and linoleic acid metabolism
Official title: ALOX15 regulation of colon cancer invasiveness via PI3P-linoleic acid metabolism
Funded at University of Michigan at Ann Arbor · NIH-11253934 · Data updated 2026-11-12
This grant explores how a specific enzyme, ALOX15, influences colon cancer invasiveness by changing a fat-related chemical pathway in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $651,815 |
| NIH project number | 5R01CA266223-05 |
| Project ID | NIH-11253934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with colorectal cancer or at high risk due to APC mutations and related pathways, who could participate in biomarker or translational studies, may benefit from future applications of this research.
✕Less likely to help
Individuals without colorectal cancer or related genetic risk factors may not benefit directly from this research.
What this research studies
Colorectal cancer remains a major cause of cancer deaths, and this research aims to uncover how fatty acids in the American diet interact with genetic mutations to drive cancer invasiveness. The study focuses on ALOX15 and its metabolism of linoleic acid to regulate a signaling pathway (PI3P and beta-catenin) that promotes tumor growth and spread. By combining molecular analysis in model systems with human-relevant insights, the work seeks to identify points where interventions could prevent progression and invasiveness of colorectal cancer. Results could inform dietary considerations or targeted therapies in patients at risk or with early disease.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to reduce colorectal cancer invasiveness and improve outcomes for patients.
How similar studies have gone: Preclinical findings have shown related metabolic pathways can influence cancer progression, but translating these results to humans remains challenging and ongoing.
Where this research is happening
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University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Shureiqi, Imad — University of Michigan at Ann Arbor
- Study coordinator: Shureiqi, Imad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.