Adaptive aerobic exercise plans during chemotherapy for colon cancer
Official title: Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
Funded at Adventhealth Orlando · NIH-11419227 · Data updated 2026-11-12
This study tests personalized aerobic exercise during chemotherapy for people with colon cancer to help them stay on their planned treatment schedule and reduce side effects.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | June 3, 2022 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,229,874 |
| NIH project number | 5U01CA271279-06 |
| Project ID | NIH-11419227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with stage II-III colon cancer who are undergoing chemotherapy and willing to participate in an exercise program during treatment.
✕Less likely to help
Patients who are unable to safely exercise due to medical or other contraindications may not benefit from the intervention.
What this research studies
People with stage II-III colon cancer who need to adjust chemotherapy due to side effects may have worse outcomes. This trial uses a Bayesian, multi-stage design to compare different levels of aerobic exercise, from 75 to 300 minutes per week, plus an attention control, and adapts assignment based on how the exercise affects chemotherapy dose intensity and feasibility. Exercise sessions are planned to align with chemotherapy cycles, adjusting intensity during tougher weeks. The study will enroll 219 participants from diverse regions to see whether higher or tailored exercise helps people stay closer to their full chemotherapy plan and feel better during treatment.
Why it matters
Potential benefit: If successful, patients could experience better chemotherapy adherence and fewer toxicities, potentially improving survival outcomes.
How similar studies have gone: Prior research suggests exercise can influence treatment tolerance, but this adaptive, dose-ranging approach is relatively novel for this setting.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Brown, Justin C — Adventhealth Orlando
- Study coordinator: Brown, Justin C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.