Investigating a new treatment to target colon cancer stem cells
Official title: Unique Non-Saccharide Mimetics of Sulfated Glycosaminoglycan Target Colon Cancer Stem Cells
Funded at VA Veterans Administration Hospital · NIH-11207158 · Data updated 2026-11-12
This study is looking at a new compound called G2.2 to see if it can help stop colon cancer stem cells from growing and spreading, which could lead to better treatments for people with colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Veterans Administration Hospital NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | October 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX004584-05 |
| Project ID | NIH-11207158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those experiencing relapse or resistance to standard therapies.
✕Less likely to help
Patients with non-colorectal cancers or those who are not currently undergoing treatment for colorectal cancer may not benefit from this research.
What this research studies
This research focuses on developing unique non-sugar mimetics of glycosaminoglycans to selectively inhibit colon cancer stem cells (CSCs), which are known to contribute to cancer relapse and poor outcomes. The team will test the effectiveness of a compound called G2.2 on human colorectal cancer cells and normal intestinal cells, examining how it affects cell growth, migration, and resistance to chemotherapy. By understanding the molecular mechanisms behind this compound, the researchers aim to find a novel way to combat colorectal cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colorectal cancer that specifically target cancer stem cells, potentially reducing relapse rates.
How similar studies have gone: While the approach of targeting cancer stem cells is gaining traction, the specific use of non-sugar mimetics in this context is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
VA Veterans Administration Hospital
Richmond, United States Active
Researchers
- Principal investigator: Patel, Bhaumik B — VA Veterans Administration Hospital
- Study coordinator: Patel, Bhaumik B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.