Using zebrafish avatars to personalize colon cancer treatment
Official title: Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer
Run by University Hospital, Linkoeping · NCT06270017 · Data updated 2026-11-12
This study is testing whether using zebrafish to mimic a patient's colon cancer can help doctors find the best treatment for them.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University Hospital, Linkoeping Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Linköping, Östergötland County) |
| Status | Recruiting |
| Started | January 10, 2022 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2028 |
| Registry record updated | February 21, 2024 |
| Trial ID | NCT06270017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with colon cancer who are scheduled for radical colon resection and are willing to participate.
✕Probably not a fit
Patients who are not diagnosed with colon cancer or those unwilling to participate in the study may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to improve the personalization of colon cancer treatment by utilizing zebrafish embryos as avatars for patient tumor tissue. By implanting a portion of the patient's tumor into the zebrafish, researchers will evaluate tumor growth, metastatic disease frequency, and responses to various chemotherapy drugs. This innovative approach seeks to move beyond the current trial-and-error method of treatment selection, providing a more reliable system for predicting individual responses to oncological therapies. If successful, this method could revolutionize how oncological treatments are tailored to patients.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized treatment options for patients with colon cancer.
How similar studies have gone: While the use of zebrafish models in cancer research is gaining traction, this specific approach to personalize colon cancer treatment is relatively novel and has not been widely tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Colon cancer planned for radical colon resection signed informed consent Exclusion Criteria: * Not willing to participate
Where it's running
-
Per Sandström
Linköping, Östergötland County, Sweden Recruiting
Study contacts
- Study coordinator: Per SANDSTROM, Prof
- Email: per.sandstrom@liu.se
- Phone: +46734058581
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
LTZ-232: a first-in-human test in advanced colorectal and other solid tumors
A first-in-human study tests LTZ-232, a new therapy for adults with unresectable or metastatic colorectal cancer and other solid tumors that have not responded to standard treatments.
-
ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer
This study tests whether tracking ctDNA can guide neoadjuvant immunotherapy and surgical decisions for people with dMMR/MSI-H colon cancer, using PD-1 inhibitors first and adding CTLA-4 inhibitors if ctDNA remains detectable.
-
Tafolecimab with chemoimmunotherapy as neoadjuvant treatment for locally advanced colon cancer
This study tests whether adding tafolecimab to a chemoimmunotherapy regimen helps shrink locally advanced colon cancer before surgery in adults who have pMMR/MSS tumors.
-
Neoadjuvant pembrolizumab and porustobart for resectable MSS colon cancer
This trial tests whether giving pembrolizumab with porustobart before surgery can shrink MSS colon cancer and improve outcomes, comparing one versus two doses of porustobart.
-
DEM301 in advanced colorectal cancer: a first-in-human test
This first-in-human Phase 1 study tests DEM301 in adults with advanced metastatic colorectal cancer to see if it is safe, how it behaves in the body, and whether it shows any signs of activity.
-
SHY-ONC6: a new anti-cancer drug tested in adults with advanced solid tumors
This early-phase study tests SHY-ONC6 to see if it is safe and can help people with advanced solid tumors after standard therapies have failed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.