Clinical trial Recruiting at 1 site Phase1; Phase2 Interventional Ages 18 and up

Using zebrafish avatars to personalize colon cancer treatment

Official title: Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer

Run by University Hospital, Linkoeping · NCT06270017 · Data updated 2026-11-12

This study is testing whether using zebrafish to mimic a patient's colon cancer can help doctors find the best treatment for them.

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment300 (estimated)
SponsorUniversity Hospital, Linkoeping
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Linköping, Östergötland County)
StatusRecruiting
StartedJanuary 10, 2022
Main results expectedDecember 31, 2025
Study endsDecember 31, 2028
Registry record updatedFebruary 21, 2024
Trial IDNCT06270017 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients with colon cancer who are scheduled for radical colon resection and are willing to participate.

Probably not a fit

Patients who are not diagnosed with colon cancer or those unwilling to participate in the study may not benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve the personalization of colon cancer treatment by utilizing zebrafish embryos as avatars for patient tumor tissue. By implanting a portion of the patient's tumor into the zebrafish, researchers will evaluate tumor growth, metastatic disease frequency, and responses to various chemotherapy drugs. This innovative approach seeks to move beyond the current trial-and-error method of treatment selection, providing a more reliable system for predicting individual responses to oncological therapies. If successful, this method could revolutionize how oncological treatments are tailored to patients.

Why it matters

Potential benefit: If successful, this approach could lead to more effective and personalized treatment options for patients with colon cancer.

How similar studies have gone: While the use of zebrafish models in cancer research is gaining traction, this specific approach to personalize colon cancer treatment is relatively novel and has not been widely tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Colon cancer planned for radical colon resection signed informed consent

Exclusion Criteria:

* Not willing to participate

Where it's running

  • Per Sandström
    Linköping, Östergötland County, Sweden
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.