Using zebrafish avatars to personalize colon cancer treatment
Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer
PHASE1; PHASE2 · University Hospital, Linkoeping · NCT06270017
This study is testing whether using zebrafish to mimic a patient's colon cancer can help doctors find the best treatment for them.
Quick facts
| Phase | PHASE1; PHASE2 |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Linkoeping (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Linköping, Östergötland County) |
| Trial ID | NCT06270017 on ClinicalTrials.gov |
What this trial studies
This study aims to improve the personalization of colon cancer treatment by utilizing zebrafish embryos as avatars for patient tumor tissue. By implanting a portion of the patient's tumor into the zebrafish, researchers will evaluate tumor growth, metastatic disease frequency, and responses to various chemotherapy drugs. This innovative approach seeks to move beyond the current trial-and-error method of treatment selection, providing a more reliable system for predicting individual responses to oncological therapies. If successful, this method could revolutionize how oncological treatments are tailored to patients.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with colon cancer who are scheduled for radical colon resection and are willing to participate.
Not a fit: Patients who are not diagnosed with colon cancer or those unwilling to participate in the study may not benefit from this approach.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized treatment options for patients with colon cancer.
How similar studies have performed: While the use of zebrafish models in cancer research is gaining traction, this specific approach to personalize colon cancer treatment is relatively novel and has not been widely tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Colon cancer planned for radical colon resection signed informed consent Exclusion Criteria: * Not willing to participate
Where this trial is running
Linköping, Östergötland County
- Per Sandström — Linköping, Östergötland County, Sweden (RECRUITING)
Study contacts
- Study coordinator: Per SANDSTROM, Prof
- Email: per.sandstrom@liu.se
- Phone: +46734058581
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Colon Cancer, drug therapy, Zebra fish embryo model